Neutrophil‐derived extracellular vesicles promote feed‐forward inflammasome signaling in cystic fibrosis airways

Cystic fibrosis (CF) airways feature high extracellular levels of the IL‐1 family of proinflammatory mediators. These mediators are cleavage products of caspase‐1, the final protease in the inflammasome cascade. Due to the proven chronic presence of reprogrammed neutrophils in the CF airway lumen, u...

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Veröffentlicht in:	Journal of leukocyte biology 2022-10, Vol.112 (4), p.707-716
Hauptverfasser:	Forrest, Osric A., Dobosh, Brian, Ingersoll, Sarah A., Rao, Sanjana, Rojas, Alexander, Laval, Julie, Alvarez, Jessica A., Brown, Milton R., Tangpricha, Vin, Tirouvanziam, Rabindra
Format:	Artikel
Sprache:	eng
Schlagworte:	caspase exocytosis IL‐1 inflammation neutrophil elastase reprogramming
Online-Zugang:	Volltext
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