Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis

B-1 cell development mainly occurs via fetal and neonatal hematopoiesis and is suppressed in adult bone marrow hematopoiesis. However, little is known about the factors inhibiting B-1 cell development at the adult stage. We report that capicua (CIC) suppresses postnatal B-1a cell development and sur...

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Veröffentlicht in:	Cell reports (Cambridge) 2022-02, Vol.38 (7), p.110386-110386, Article 110386
Hauptverfasser:	Hong, Hyebeen, Lee, Jongeun, Park, Guk-Yeol, Kim, Soeun, Park, Jiho, Park, Jong Seok, Song, Youngkwon, Lee, Sujin, Kim, Tae Jin, Lee, You Jeong, Roh, Tae-Young, Kwok, Seung-Ki, Kim, Sung Won, Tan, Qiumin, Lee, Yoontae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis B cell development B-1a B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - metabolism Base Sequence Basic Helix-Loop-Helix Transcription Factors - metabolism BCR signaling BHLHE41 Bone Marrow - embryology capicua Cell Differentiation Cell Survival Child Child, Preschool Fetus - embryology HEK293 Cells Humans Liver - embryology Mice Mice, Inbred C57BL Mice, Mutant Strains NIH 3T3 Cells PER2 Period Circadian Proteins - metabolism Receptors, Antigen, B-Cell - metabolism Repressor Proteins - metabolism Signal Transduction TrB-1a
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