Features of Local Expression of Genes of Immune Response Cytokines and Trophic and Vasoregulatory Factors in Modeling of Retinal Pigment Epithelium Atrophy

Local expression of genes encoding IL-1β, IL-18, MCP-1/CCL2, PEDF, VEGF-A, and ZO-1 in the retina—retinal pigment epithelium—chorioidea tissue complex was studied in healthy rabbits and animals with simulated retinal pigment epithelium atrophy. Retinal pigment epithelium atrophy was modeled by singl...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2022-02, Vol.172 (4), p.453-459
Hauptverfasser:	Neroeva, N. V., Balatskaya, N. V., Neroev, V. V., Svetlova, E. V., Ryabinа, M. V., Ilyukhin, P. A., Karmokova, A. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis inhibitors Animals Atrophy Atrophy - genetics Atrophy - metabolism Atrophy - pathology Bevacizumab Biomedical and Life Sciences Biomedicine Cell Biology Cytokines Cytokines - genetics Cytokines - metabolism Drug development Epithelium Gene expression Genes Genetic aspects Genetic transcription Genetics IL-1β Immune privilege Immune response Immunity Immunosuppressive agents Interleukin 18 Internal Medicine Laboratory Medicine Monocyte chemoattractant protein 1 Pathology Permeability Rabbits Retina Retinal Pigment Epithelium Reverse transcription RNA Serpins - genetics Serpins - metabolism Sodium chloride Stem cell transplantation Stem cells Transplantation Vascular endothelial growth factor Zonula occludens-1 protein
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