TRIM39 is a poor prognostic factor for patients with estrogen receptor‐positive breast cancer and promotes cell cycle progression

Tripartite motif (TRIM) family proteins are involved in various biological processes and the pathophysiology of cancers. However, the roles of TRIM39, a TRIM family member, in breast cancer is not well‐understood. Here, we performed immunohistochemical study of TRIM39 protein in clinical estrogen re...

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Veröffentlicht in:	Pathology international 2022-02, Vol.72 (2), p.96-106
Hauptverfasser:	Ogura, Takuya, Azuma, Kotaro, Takeiwa, Toshihiko, Sato, Junichiro, Kinowaki, Keiichi, Ikeda, Kazuhiro, Kawabata, Hidetaka, Inoue, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological activity Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - pathology Cell Cycle Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Division Cell Line, Tumor Cell Proliferation Estrogen receptors Estrogens Female Gene Knockdown Techniques Humans Immunohistochemistry Immunoreactivity Invasiveness Lymph nodes Middle Aged Multivariate analysis Patients Prognosis Proteins Receptors Receptors, Estrogen - genetics Receptors, Estrogen - metabolism S phase siRNA tripartite motif‐containing 39 Tumors Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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Zusammenfassung:	Tripartite motif (TRIM) family proteins are involved in various biological processes and the pathophysiology of cancers. However, the roles of TRIM39, a TRIM family member, in breast cancer is not well‐understood. Here, we performed immunohistochemical study of TRIM39 protein in clinical estrogen receptor‐positive (ER+) breast cancer tissues from 108 patients. TRIM39 immunoreactivity (IR) was positively correlated with advanced stage (p
ISSN:	1320-5463 1440-1827
DOI:	10.1111/pin.13190