Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications
The interleukin (IL)-1 superfamily of cytokines comprises 11 pro- and anti-inflammatory cytokines, which play essential roles during the immune response. Several pathogenic pathways are initiated by IL-1RL2 (interleukin 1 receptor-like 2) signaling, also known as IL-36R, in the skin, lungs, and gut....
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| Veröffentlicht in: | Journal of interferon & cytokine research 2022-02, Vol.42 (2), p.49-61 |
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| creator | Manzanares-Meza, Laura D Valle-Rios, Ricardo Medina-Contreras, Oscar |
| description | The interleukin (IL)-1 superfamily of cytokines comprises 11 pro- and anti-inflammatory cytokines, which play essential roles during the immune response. Several pathogenic pathways are initiated by IL-1RL2 (interleukin 1 receptor-like 2) signaling, also known as IL-36R, in the skin, lungs, and gut. IL-36 cytokines promote the secretion of proinflammatory cytokines and chemokines, upregulation of antimicrobial peptides, proliferation mediators, and adhesion molecules on endothelial cells. In addition, the IL-36-IL-1RL2 axis has an essential role against viral infections, including a potential role in COVID-19 pathology. The evidence presented in this review highlights the importance of the axis IL-36-IL-1RL2 in the development of several inflammation-related diseases and the healing process. It suggests that IL-1RL2 ligands have specific roles depending on the tissue or cell source. However, there is still much to discover about this cytokine family, their functions in other organs, and how they accomplish a dual effect in inflammation and healing. |
| doi_str_mv | 10.1089/jir.2021.0173 |
| format | Article |
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Several pathogenic pathways are initiated by IL-1RL2 (interleukin 1 receptor-like 2) signaling, also known as IL-36R, in the skin, lungs, and gut. IL-36 cytokines promote the secretion of proinflammatory cytokines and chemokines, upregulation of antimicrobial peptides, proliferation mediators, and adhesion molecules on endothelial cells. In addition, the IL-36-IL-1RL2 axis has an essential role against viral infections, including a potential role in COVID-19 pathology. The evidence presented in this review highlights the importance of the axis IL-36-IL-1RL2 in the development of several inflammation-related diseases and the healing process. It suggests that IL-1RL2 ligands have specific roles depending on the tissue or cell source. However, there is still much to discover about this cytokine family, their functions in other organs, and how they accomplish a dual effect in inflammation and healing.</description><identifier>ISSN: 1079-9907</identifier><identifier>EISSN: 1557-7465</identifier><identifier>DOI: 10.1089/jir.2021.0173</identifier><identifier>PMID: 35171706</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Animals ; Antiinfectives and antibacterials ; Antimicrobial peptides ; Cell adhesion molecules ; Cell proliferation ; Chemokines ; COVID-19 ; COVID-19 - physiopathology ; Cytokine Release Syndrome - physiopathology ; Cytokines ; Cytokines - physiology ; Endothelial cells ; Healing ; Host-Pathogen Interactions ; Humans ; Immune response ; Inflammation ; Inflammation - physiopathology ; Interleukin 1 ; Interleukin 1 receptors ; Interleukin-1 - physiology ; Interleukins - classification ; Intestines - metabolism ; Intestines - pathology ; Ligands ; Lung - metabolism ; Lung - pathology ; MAP Kinase Signaling System ; Mice ; NF-kappa B - metabolism ; Organs ; Peptides ; Protein Domains ; Receptors ; Receptors, Interleukin - classification ; Receptors, Interleukin-1 - agonists ; Receptors, Interleukin-1 - antagonists & inhibitors ; Receptors, Interleukin-1 - chemistry ; Receptors, Interleukin-1 - physiology ; SARS-CoV-2 ; Signal Transduction ; Skin - metabolism ; Skin - pathology</subject><ispartof>Journal of interferon & cytokine research, 2022-02, Vol.42 (2), p.49-61</ispartof><rights>Copyright Mary Ann Liebert, Inc. 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Several pathogenic pathways are initiated by IL-1RL2 (interleukin 1 receptor-like 2) signaling, also known as IL-36R, in the skin, lungs, and gut. IL-36 cytokines promote the secretion of proinflammatory cytokines and chemokines, upregulation of antimicrobial peptides, proliferation mediators, and adhesion molecules on endothelial cells. In addition, the IL-36-IL-1RL2 axis has an essential role against viral infections, including a potential role in COVID-19 pathology. The evidence presented in this review highlights the importance of the axis IL-36-IL-1RL2 in the development of several inflammation-related diseases and the healing process. It suggests that IL-1RL2 ligands have specific roles depending on the tissue or cell source. However, there is still much to discover about this cytokine family, their functions in other organs, and how they accomplish a dual effect in inflammation and healing.</description><subject>Animals</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial peptides</subject><subject>Cell adhesion molecules</subject><subject>Cell proliferation</subject><subject>Chemokines</subject><subject>COVID-19</subject><subject>COVID-19 - physiopathology</subject><subject>Cytokine Release Syndrome - physiopathology</subject><subject>Cytokines</subject><subject>Cytokines - physiology</subject><subject>Endothelial cells</subject><subject>Healing</subject><subject>Host-Pathogen Interactions</subject><subject>Humans</subject><subject>Immune response</subject><subject>Inflammation</subject><subject>Inflammation - physiopathology</subject><subject>Interleukin 1</subject><subject>Interleukin 1 receptors</subject><subject>Interleukin-1 - physiology</subject><subject>Interleukins - classification</subject><subject>Intestines - metabolism</subject><subject>Intestines - pathology</subject><subject>Ligands</subject><subject>Lung - metabolism</subject><subject>Lung - pathology</subject><subject>MAP Kinase Signaling System</subject><subject>Mice</subject><subject>NF-kappa B - metabolism</subject><subject>Organs</subject><subject>Peptides</subject><subject>Protein Domains</subject><subject>Receptors</subject><subject>Receptors, Interleukin - classification</subject><subject>Receptors, Interleukin-1 - agonists</subject><subject>Receptors, Interleukin-1 - antagonists & inhibitors</subject><subject>Receptors, Interleukin-1 - chemistry</subject><subject>Receptors, Interleukin-1 - physiology</subject><subject>SARS-CoV-2</subject><subject>Signal Transduction</subject><subject>Skin - metabolism</subject><subject>Skin - pathology</subject><issn>1079-9907</issn><issn>1557-7465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkD1PwzAQhi0EoqUwsiJLLAxNsZ0P22xVxUelokpVmS0nuUDaxAl2MvTf49LSgenuXj16dXoQuqVkQomQj5vSThhhdEIoD8_QkMYxD3iUxOd-J1wGUhI-QFfObQghiWDyEg3CmHLKSTJEq7npwFbQb0sTULyCDNquscGi3AJmT3hp4BSO8frLAuDpZ2NK17kx1ibH79rs8LxuqzLTXdkYd40uCl05uDnOEfp4eV7P3oLF8nU-my6CLGS0CwqQglMWhZEExtM893dEWK6FIEWieSJAp0IXEZcpjzTnKclCIWhKQRZciHCEHg69rW2-e3CdqkuXQVVpA03vFEuYb5SxpB69_4dumt4a_90vRRlNYuKp4EBltnHOQqFaW9ba7hQlai9bedlqL1vtZXv-7tjapzXkJ_rPbvgDb-N4Iw</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Manzanares-Meza, Laura D</creator><creator>Valle-Rios, Ricardo</creator><creator>Medina-Contreras, Oscar</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4432-7780</orcidid></search><sort><creationdate>202202</creationdate><title>Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications</title><author>Manzanares-Meza, Laura D ; 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| subjects | Animals Antiinfectives and antibacterials Antimicrobial peptides Cell adhesion molecules Cell proliferation Chemokines COVID-19 COVID-19 - physiopathology Cytokine Release Syndrome - physiopathology Cytokines Cytokines - physiology Endothelial cells Healing Host-Pathogen Interactions Humans Immune response Inflammation Inflammation - physiopathology Interleukin 1 Interleukin 1 receptors Interleukin-1 - physiology Interleukins - classification Intestines - metabolism Intestines - pathology Ligands Lung - metabolism Lung - pathology MAP Kinase Signaling System Mice NF-kappa B - metabolism Organs Peptides Protein Domains Receptors Receptors, Interleukin - classification Receptors, Interleukin-1 - agonists Receptors, Interleukin-1 - antagonists & inhibitors Receptors, Interleukin-1 - chemistry Receptors, Interleukin-1 - physiology SARS-CoV-2 Signal Transduction Skin - metabolism Skin - pathology |
| title | Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications |
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