Cavity-based free energy analysis of osmolyte effects on protein denaturation

Experimental measurements of the thermal effects of the same osmolytes on two different globular proteins, C-reactive protein (CRP) and tumor necrosis factor alpha (TNFα), have shown that quantifying the change in the denaturing temperature leads to some results that are unique to each protein. In o...

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Veröffentlicht in:	Physical chemistry chemical physics : PCCP 2022-03, Vol.24 (9), p.5394-543
Hauptverfasser:	Heying, Michael, Lam, Kevin, Canepa, Jacob, Richardson, Abigail D, Wilkinson, Steven P
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopolymer denaturation Free energy Mathematical models Osmolar Concentration Parameters Protein Denaturation Proteins Proteins - metabolism Temperature Temperature effects Thermodynamics
Online-Zugang:	Volltext
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