Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana
Abstract Objectives Sickle Cell Disease (SCD) is a genetic blood disorder affecting over 1 million people globally. The aim of this analysis is to explore the pain burden of patients with SCD in two countries: the United States and Ghana. Methods The Consortium for the Advancement of Sickle Cell Res...
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| Veröffentlicht in: | Pain medicine (Malden, Mass.) Mass.), 2022-08, Vol.23 (8), p.1379-1386 |
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| creator | Zempsky, William T Yanaros, Mary Sayeem, Mohammed Boruchov, Donna Piccone, Connie M Manwani, Deepa Strunk, Crawford Tartaglione, Immacolata Colombatti, Raffaella Akatue, Sophia Oteng, Bianca Owda, Ahmed Bamfo, Rose Wilson, Samuel Rivers, Angela Farooq, Fatimah Urbonya, Rebekah Boatemaa, Gifty Dankwah Rao, Sudha Inusa, Baba Antwi-Boasiako, Charles Segbefia, Catherine Sey, Fredericka Andemariam, Biree Asare, Eugenia Vicky Campbell, Andrew D |
| description | Abstract
Objectives
Sickle Cell Disease (SCD) is a genetic blood disorder affecting over 1 million people globally. The aim of this analysis is to explore the pain burden of patients with SCD in two countries: the United States and Ghana.
Methods
The Consortium for the Advancement of Sickle Cell Research (CASiRe) was created to better understand the clinical severity of patients with SCD worldwide. Data regarding gender, SCD genotype, prior medical diagnoses, and validated pain burden measures were analyzed from the CASiRe database. The Sickle Cell Pain Burden Interview (SCPBI) was used to assess pain burden, the impact of pain on physical, emotional, and social function.
Results
Most subjects identified as Black/African American (n = 298, 97.0%). Patient ages ranged from 6 to 73 years. 35.9% resided in the United States, 64.1% resided in Ghana, 40.9% were men, and 58.7% were women. The mean SCPBI score for US SCD patients was 6.53(±5.89) vs 4.04(±5.10) for Ghanaian patients, P |
| doi_str_mv | 10.1093/pm/pnac023 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2629060863</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A776035310</galeid><oup_id>10.1093/pm/pnac023</oup_id><sourcerecordid>A776035310</sourcerecordid><originalsourceid>FETCH-LOGICAL-c371t-c5b5f1a30ca93336c8d17e16f44873b8637e45b86bfa82fe9da33664f8d3f87f3</originalsourceid><addsrcrecordid>eNp90VFrFDEQAOAgiq3VF3-ABEQQ4dpks5vs-nYe2hYKLZ59DnPZiZe6m2yT7IP_3hx3KhUpeZiQfDPMMIS85uyUs06cTePZ5MGwSjwhx7yp5KKWQj093CuhmiPyIqU7xrisW_GcHImGS9k2_JjoG3Cefppjj56WW94iXS3X7ivSS58xesgueBjoKmxDzDRYunbmx1AUDgO9Kd_oc_pIb73L2NN1hoyJgu_p-RY8vCTPLAwJXx3iCbn98vnb6mJxdX1-uVpeLYxQPC9Ms2ksB8EMdEIIadqeK-TS1nWrxKYt82DdlLix0FYWux6KkrVte2FbZcUJeb-vO8VwP2PKenTJlBbBY5iTrmTVMclKoULf_kPvwlwGHXaq6wpSTP5V32FA7bwNOYLZFdVLpSQTjeCsqNP_qHJ6HJ0JHq0r7w8SPuwTTAwpRbR6im6E-FNzpnfb1NOoD9ss-M2h03kzYv-H_l5fAe_2IMzTY4V-Adl7pFE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2699608706</pqid></control><display><type>article</type><title>Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Zempsky, William T ; Yanaros, Mary ; Sayeem, Mohammed ; Boruchov, Donna ; Piccone, Connie M ; Manwani, Deepa ; Strunk, Crawford ; Tartaglione, Immacolata ; Colombatti, Raffaella ; Akatue, Sophia ; Oteng, Bianca ; Owda, Ahmed ; Bamfo, Rose ; Wilson, Samuel ; Rivers, Angela ; Farooq, Fatimah ; Urbonya, Rebekah ; Boatemaa, Gifty Dankwah ; Rao, Sudha ; Inusa, Baba ; Antwi-Boasiako, Charles ; Segbefia, Catherine ; Sey, Fredericka ; Andemariam, Biree ; Asare, Eugenia Vicky ; Campbell, Andrew D</creator><creatorcontrib>Zempsky, William T ; Yanaros, Mary ; Sayeem, Mohammed ; Boruchov, Donna ; Piccone, Connie M ; Manwani, Deepa ; Strunk, Crawford ; Tartaglione, Immacolata ; Colombatti, Raffaella ; Akatue, Sophia ; Oteng, Bianca ; Owda, Ahmed ; Bamfo, Rose ; Wilson, Samuel ; Rivers, Angela ; Farooq, Fatimah ; Urbonya, Rebekah ; Boatemaa, Gifty Dankwah ; Rao, Sudha ; Inusa, Baba ; Antwi-Boasiako, Charles ; Segbefia, Catherine ; Sey, Fredericka ; Andemariam, Biree ; Asare, Eugenia Vicky ; Campbell, Andrew D</creatorcontrib><description>Abstract
Objectives
Sickle Cell Disease (SCD) is a genetic blood disorder affecting over 1 million people globally. The aim of this analysis is to explore the pain burden of patients with SCD in two countries: the United States and Ghana.
Methods
The Consortium for the Advancement of Sickle Cell Research (CASiRe) was created to better understand the clinical severity of patients with SCD worldwide. Data regarding gender, SCD genotype, prior medical diagnoses, and validated pain burden measures were analyzed from the CASiRe database. The Sickle Cell Pain Burden Interview (SCPBI) was used to assess pain burden, the impact of pain on physical, emotional, and social function.
Results
Most subjects identified as Black/African American (n = 298, 97.0%). Patient ages ranged from 6 to 73 years. 35.9% resided in the United States, 64.1% resided in Ghana, 40.9% were men, and 58.7% were women. The mean SCPBI score for US SCD patients was 6.53(±5.89) vs 4.04(±5.10) for Ghanaian patients, P <0.001. Pain burden was higher in US men vs Ghanaian men (6.74(±5.68) vs 3.54(±4.46), P = .003) and in US women vs Ghanaian women (6.37 ± 6.06 vs 4.44(±5.54), P = .032). Pain burden was higher in US patients than Ghanaian patients for both the Hb SC/SBeta+ genotype (5.40(±5.29) vs 2.82(±4.86), P = .054) and Hb SS/SBeta0 genotype (6.79(±6.01) vs 4.49(±5.13), P = .003). Pain burden was significantly higher in SCD patients with comorbid conditions independent of geographic origin including stroke, cholecystectomy, gallstones, depression, and headache.
Discussion
US patients with SCD have a higher pain burden than Ghanaian patients. Further studies should investigate underlying contributors to pain burden in these populations and further explore the etiology of geographic differences in pain.</description><identifier>ISSN: 1526-2375</identifier><identifier>EISSN: 1526-4637</identifier><identifier>DOI: 10.1093/pm/pnac023</identifier><identifier>PMID: 35166851</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Care and treatment ; Cholecystectomy ; Chronic pain ; Complications and side effects ; Demographic aspects ; Development and progression ; Epidemiology ; Ethnicity ; Etiology ; Genotype & phenotype ; Genotypes ; Health aspects ; Pain ; Pain management ; Patients ; Sickle cell anemia ; Sickle cell disease</subject><ispartof>Pain medicine (Malden, Mass.), 2022-08, Vol.23 (8), p.1379-1386</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the American Academy of Pain Medicine.</rights><rights>COPYRIGHT 2022 Oxford University Press</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c371t-c5b5f1a30ca93336c8d17e16f44873b8637e45b86bfa82fe9da33664f8d3f87f3</cites><orcidid>0000-0003-4438-5187</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1579,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35166851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zempsky, William T</creatorcontrib><creatorcontrib>Yanaros, Mary</creatorcontrib><creatorcontrib>Sayeem, Mohammed</creatorcontrib><creatorcontrib>Boruchov, Donna</creatorcontrib><creatorcontrib>Piccone, Connie M</creatorcontrib><creatorcontrib>Manwani, Deepa</creatorcontrib><creatorcontrib>Strunk, Crawford</creatorcontrib><creatorcontrib>Tartaglione, Immacolata</creatorcontrib><creatorcontrib>Colombatti, Raffaella</creatorcontrib><creatorcontrib>Akatue, Sophia</creatorcontrib><creatorcontrib>Oteng, Bianca</creatorcontrib><creatorcontrib>Owda, Ahmed</creatorcontrib><creatorcontrib>Bamfo, Rose</creatorcontrib><creatorcontrib>Wilson, Samuel</creatorcontrib><creatorcontrib>Rivers, Angela</creatorcontrib><creatorcontrib>Farooq, Fatimah</creatorcontrib><creatorcontrib>Urbonya, Rebekah</creatorcontrib><creatorcontrib>Boatemaa, Gifty Dankwah</creatorcontrib><creatorcontrib>Rao, Sudha</creatorcontrib><creatorcontrib>Inusa, Baba</creatorcontrib><creatorcontrib>Antwi-Boasiako, Charles</creatorcontrib><creatorcontrib>Segbefia, Catherine</creatorcontrib><creatorcontrib>Sey, Fredericka</creatorcontrib><creatorcontrib>Andemariam, Biree</creatorcontrib><creatorcontrib>Asare, Eugenia Vicky</creatorcontrib><creatorcontrib>Campbell, Andrew D</creatorcontrib><title>Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana</title><title>Pain medicine (Malden, Mass.)</title><addtitle>Pain Med</addtitle><description>Abstract
Objectives
Sickle Cell Disease (SCD) is a genetic blood disorder affecting over 1 million people globally. The aim of this analysis is to explore the pain burden of patients with SCD in two countries: the United States and Ghana.
Methods
The Consortium for the Advancement of Sickle Cell Research (CASiRe) was created to better understand the clinical severity of patients with SCD worldwide. Data regarding gender, SCD genotype, prior medical diagnoses, and validated pain burden measures were analyzed from the CASiRe database. The Sickle Cell Pain Burden Interview (SCPBI) was used to assess pain burden, the impact of pain on physical, emotional, and social function.
Results
Most subjects identified as Black/African American (n = 298, 97.0%). Patient ages ranged from 6 to 73 years. 35.9% resided in the United States, 64.1% resided in Ghana, 40.9% were men, and 58.7% were women. The mean SCPBI score for US SCD patients was 6.53(±5.89) vs 4.04(±5.10) for Ghanaian patients, P <0.001. Pain burden was higher in US men vs Ghanaian men (6.74(±5.68) vs 3.54(±4.46), P = .003) and in US women vs Ghanaian women (6.37 ± 6.06 vs 4.44(±5.54), P = .032). Pain burden was higher in US patients than Ghanaian patients for both the Hb SC/SBeta+ genotype (5.40(±5.29) vs 2.82(±4.86), P = .054) and Hb SS/SBeta0 genotype (6.79(±6.01) vs 4.49(±5.13), P = .003). Pain burden was significantly higher in SCD patients with comorbid conditions independent of geographic origin including stroke, cholecystectomy, gallstones, depression, and headache.
Discussion
US patients with SCD have a higher pain burden than Ghanaian patients. Further studies should investigate underlying contributors to pain burden in these populations and further explore the etiology of geographic differences in pain.</description><subject>Care and treatment</subject><subject>Cholecystectomy</subject><subject>Chronic pain</subject><subject>Complications and side effects</subject><subject>Demographic aspects</subject><subject>Development and progression</subject><subject>Epidemiology</subject><subject>Ethnicity</subject><subject>Etiology</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Health aspects</subject><subject>Pain</subject><subject>Pain management</subject><subject>Patients</subject><subject>Sickle cell anemia</subject><subject>Sickle cell disease</subject><issn>1526-2375</issn><issn>1526-4637</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90VFrFDEQAOAgiq3VF3-ABEQQ4dpks5vs-nYe2hYKLZ59DnPZiZe6m2yT7IP_3hx3KhUpeZiQfDPMMIS85uyUs06cTePZ5MGwSjwhx7yp5KKWQj093CuhmiPyIqU7xrisW_GcHImGS9k2_JjoG3Cefppjj56WW94iXS3X7ivSS58xesgueBjoKmxDzDRYunbmx1AUDgO9Kd_oc_pIb73L2NN1hoyJgu_p-RY8vCTPLAwJXx3iCbn98vnb6mJxdX1-uVpeLYxQPC9Ms2ksB8EMdEIIadqeK-TS1nWrxKYt82DdlLix0FYWux6KkrVte2FbZcUJeb-vO8VwP2PKenTJlBbBY5iTrmTVMclKoULf_kPvwlwGHXaq6wpSTP5V32FA7bwNOYLZFdVLpSQTjeCsqNP_qHJ6HJ0JHq0r7w8SPuwTTAwpRbR6im6E-FNzpnfb1NOoD9ss-M2h03kzYv-H_l5fAe_2IMzTY4V-Adl7pFE</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Zempsky, William T</creator><creator>Yanaros, Mary</creator><creator>Sayeem, Mohammed</creator><creator>Boruchov, Donna</creator><creator>Piccone, Connie M</creator><creator>Manwani, Deepa</creator><creator>Strunk, Crawford</creator><creator>Tartaglione, Immacolata</creator><creator>Colombatti, Raffaella</creator><creator>Akatue, Sophia</creator><creator>Oteng, Bianca</creator><creator>Owda, Ahmed</creator><creator>Bamfo, Rose</creator><creator>Wilson, Samuel</creator><creator>Rivers, Angela</creator><creator>Farooq, Fatimah</creator><creator>Urbonya, Rebekah</creator><creator>Boatemaa, Gifty Dankwah</creator><creator>Rao, Sudha</creator><creator>Inusa, Baba</creator><creator>Antwi-Boasiako, Charles</creator><creator>Segbefia, Catherine</creator><creator>Sey, Fredericka</creator><creator>Andemariam, Biree</creator><creator>Asare, Eugenia Vicky</creator><creator>Campbell, Andrew D</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4438-5187</orcidid></search><sort><creationdate>20220801</creationdate><title>Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana</title><author>Zempsky, William T ; Yanaros, Mary ; Sayeem, Mohammed ; Boruchov, Donna ; Piccone, Connie M ; Manwani, Deepa ; Strunk, Crawford ; Tartaglione, Immacolata ; Colombatti, Raffaella ; Akatue, Sophia ; Oteng, Bianca ; Owda, Ahmed ; Bamfo, Rose ; Wilson, Samuel ; Rivers, Angela ; Farooq, Fatimah ; Urbonya, Rebekah ; Boatemaa, Gifty Dankwah ; Rao, Sudha ; Inusa, Baba ; Antwi-Boasiako, Charles ; Segbefia, Catherine ; Sey, Fredericka ; Andemariam, Biree ; Asare, Eugenia Vicky ; Campbell, Andrew D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-c5b5f1a30ca93336c8d17e16f44873b8637e45b86bfa82fe9da33664f8d3f87f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Care and treatment</topic><topic>Cholecystectomy</topic><topic>Chronic pain</topic><topic>Complications and side effects</topic><topic>Demographic aspects</topic><topic>Development and progression</topic><topic>Epidemiology</topic><topic>Ethnicity</topic><topic>Etiology</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Health aspects</topic><topic>Pain</topic><topic>Pain management</topic><topic>Patients</topic><topic>Sickle cell anemia</topic><topic>Sickle cell disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zempsky, William T</creatorcontrib><creatorcontrib>Yanaros, Mary</creatorcontrib><creatorcontrib>Sayeem, Mohammed</creatorcontrib><creatorcontrib>Boruchov, Donna</creatorcontrib><creatorcontrib>Piccone, Connie M</creatorcontrib><creatorcontrib>Manwani, Deepa</creatorcontrib><creatorcontrib>Strunk, Crawford</creatorcontrib><creatorcontrib>Tartaglione, Immacolata</creatorcontrib><creatorcontrib>Colombatti, Raffaella</creatorcontrib><creatorcontrib>Akatue, Sophia</creatorcontrib><creatorcontrib>Oteng, Bianca</creatorcontrib><creatorcontrib>Owda, Ahmed</creatorcontrib><creatorcontrib>Bamfo, Rose</creatorcontrib><creatorcontrib>Wilson, Samuel</creatorcontrib><creatorcontrib>Rivers, Angela</creatorcontrib><creatorcontrib>Farooq, Fatimah</creatorcontrib><creatorcontrib>Urbonya, Rebekah</creatorcontrib><creatorcontrib>Boatemaa, Gifty Dankwah</creatorcontrib><creatorcontrib>Rao, Sudha</creatorcontrib><creatorcontrib>Inusa, Baba</creatorcontrib><creatorcontrib>Antwi-Boasiako, Charles</creatorcontrib><creatorcontrib>Segbefia, Catherine</creatorcontrib><creatorcontrib>Sey, Fredericka</creatorcontrib><creatorcontrib>Andemariam, Biree</creatorcontrib><creatorcontrib>Asare, Eugenia Vicky</creatorcontrib><creatorcontrib>Campbell, Andrew D</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology 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Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Pain medicine (Malden, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zempsky, William T</au><au>Yanaros, Mary</au><au>Sayeem, Mohammed</au><au>Boruchov, Donna</au><au>Piccone, Connie M</au><au>Manwani, Deepa</au><au>Strunk, Crawford</au><au>Tartaglione, Immacolata</au><au>Colombatti, Raffaella</au><au>Akatue, Sophia</au><au>Oteng, Bianca</au><au>Owda, Ahmed</au><au>Bamfo, Rose</au><au>Wilson, Samuel</au><au>Rivers, Angela</au><au>Farooq, Fatimah</au><au>Urbonya, Rebekah</au><au>Boatemaa, Gifty Dankwah</au><au>Rao, Sudha</au><au>Inusa, Baba</au><au>Antwi-Boasiako, Charles</au><au>Segbefia, Catherine</au><au>Sey, Fredericka</au><au>Andemariam, Biree</au><au>Asare, Eugenia Vicky</au><au>Campbell, Andrew D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana</atitle><jtitle>Pain medicine (Malden, Mass.)</jtitle><addtitle>Pain Med</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>23</volume><issue>8</issue><spage>1379</spage><epage>1386</epage><pages>1379-1386</pages><issn>1526-2375</issn><eissn>1526-4637</eissn><abstract>Abstract
Objectives
Sickle Cell Disease (SCD) is a genetic blood disorder affecting over 1 million people globally. The aim of this analysis is to explore the pain burden of patients with SCD in two countries: the United States and Ghana.
Methods
The Consortium for the Advancement of Sickle Cell Research (CASiRe) was created to better understand the clinical severity of patients with SCD worldwide. Data regarding gender, SCD genotype, prior medical diagnoses, and validated pain burden measures were analyzed from the CASiRe database. The Sickle Cell Pain Burden Interview (SCPBI) was used to assess pain burden, the impact of pain on physical, emotional, and social function.
Results
Most subjects identified as Black/African American (n = 298, 97.0%). Patient ages ranged from 6 to 73 years. 35.9% resided in the United States, 64.1% resided in Ghana, 40.9% were men, and 58.7% were women. The mean SCPBI score for US SCD patients was 6.53(±5.89) vs 4.04(±5.10) for Ghanaian patients, P <0.001. Pain burden was higher in US men vs Ghanaian men (6.74(±5.68) vs 3.54(±4.46), P = .003) and in US women vs Ghanaian women (6.37 ± 6.06 vs 4.44(±5.54), P = .032). Pain burden was higher in US patients than Ghanaian patients for both the Hb SC/SBeta+ genotype (5.40(±5.29) vs 2.82(±4.86), P = .054) and Hb SS/SBeta0 genotype (6.79(±6.01) vs 4.49(±5.13), P = .003). Pain burden was significantly higher in SCD patients with comorbid conditions independent of geographic origin including stroke, cholecystectomy, gallstones, depression, and headache.
Discussion
US patients with SCD have a higher pain burden than Ghanaian patients. Further studies should investigate underlying contributors to pain burden in these populations and further explore the etiology of geographic differences in pain.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>35166851</pmid><doi>10.1093/pm/pnac023</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4438-5187</orcidid></addata></record> |
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| ispartof | Pain medicine (Malden, Mass.), 2022-08, Vol.23 (8), p.1379-1386 |
| issn | 1526-2375 1526-4637 |
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| source | Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Care and treatment Cholecystectomy Chronic pain Complications and side effects Demographic aspects Development and progression Epidemiology Ethnicity Etiology Genotype & phenotype Genotypes Health aspects Pain Pain management Patients Sickle cell anemia Sickle cell disease |
| title | Pain Burden in the CASiRe International Cohort of Sickle Cell Patients: United States and Ghana |
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