LncRNA CRNDE promotes cell proliferation, migration and invasion of ovarian cancer via miR-423-5p/FSCN1 axis
Ovarian cancer seriously threatens the health of women. LncRNA CRNDE is known to be upregulated in ovarian cancer. However, the mechanism by which CRNDE regulates the progress of ovarian cancer is largely unknown. MTT assay was applied to measure the cell viability. Colony formation assay was used t...
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| Veröffentlicht in: | Molecular and cellular biochemistry 2022-05, Vol.477 (5), p.1477-1488 |
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| creator | Wang, Qiong Wang, Ling-Xiong Zhang, Chun-Yan Bai, Nan Feng, Chen Zhang, Zhuo-Mei Wang, Liang Gao, Zhen-Zhen |
| description | Ovarian cancer seriously threatens the health of women. LncRNA CRNDE is known to be upregulated in ovarian cancer. However, the mechanism by which CRNDE regulates the progress of ovarian cancer is largely unknown. MTT assay was applied to measure the cell viability. Colony formation assay was used to measure the cell proliferation. Cell migration was tested by wound healing, and Transwell assay was performed to detect cell invasion. In addition, the expression of miR-423-5p, CRNDE and FSCN1 were detected by RT-qPCR and western blotting, respectively. Meanwhile, dual-luciferase reporter assay and RIP assay were performed to explore the correlation between miR-423-5p and CRNDE (or FSCN1). CRNDE and FSCN1 were upregulated in ovarian cancer cells (SKOV3, CAOV-3, IGROV1, A2780 and C13K), while miR-423-5p was downregulated. Moreover, silencing of FSCN1/CRNDE significantly decreased proliferation, migration and invasion of ovarian cancer cells (SKOV3 and CI3K) via suppressing MMP-2 and MMP-9. In addition, CRNDE could sponge miR-423-5p, and FSCN1 was confirmed to be the direct target of miR-423-5p. Furthermore, CRNDE knockdown-induced inhibition of FSCN1 was notably reversed by miR-423-5p downregulation. Knockdown of CRNDE inhibited cell proliferation, migration and invasion of ovarian cancer via miR-423-5p/FSCN1 axis. Thus, CRNDE may serve a new target for ovarian cancer. |
| doi_str_mv | 10.1007/s11010-022-04382-8 |
| format | Article |
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LncRNA CRNDE is known to be upregulated in ovarian cancer. However, the mechanism by which CRNDE regulates the progress of ovarian cancer is largely unknown. MTT assay was applied to measure the cell viability. Colony formation assay was used to measure the cell proliferation. Cell migration was tested by wound healing, and Transwell assay was performed to detect cell invasion. In addition, the expression of miR-423-5p, CRNDE and FSCN1 were detected by RT-qPCR and western blotting, respectively. Meanwhile, dual-luciferase reporter assay and RIP assay were performed to explore the correlation between miR-423-5p and CRNDE (or FSCN1). CRNDE and FSCN1 were upregulated in ovarian cancer cells (SKOV3, CAOV-3, IGROV1, A2780 and C13K), while miR-423-5p was downregulated. Moreover, silencing of FSCN1/CRNDE significantly decreased proliferation, migration and invasion of ovarian cancer cells (SKOV3 and CI3K) via suppressing MMP-2 and MMP-9. In addition, CRNDE could sponge miR-423-5p, and FSCN1 was confirmed to be the direct target of miR-423-5p. Furthermore, CRNDE knockdown-induced inhibition of FSCN1 was notably reversed by miR-423-5p downregulation. Knockdown of CRNDE inhibited cell proliferation, migration and invasion of ovarian cancer via miR-423-5p/FSCN1 axis. Thus, CRNDE may serve a new target for ovarian cancer.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-022-04382-8</identifier><identifier>PMID: 35166986</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Assaying ; Biochemistry ; Biomedical and Life Sciences ; Cancer ; Carcinoma, Ovarian Epithelial - genetics ; Cardiology ; Carrier Proteins - genetics ; Cell growth ; Cell Line, Tumor ; Cell migration ; Cell Movement - genetics ; Cell proliferation ; Cell Proliferation - genetics ; Cell viability ; Female ; Gelatinase A ; Gelatinase B ; Gene Expression Regulation, Neoplastic ; Health aspects ; Humans ; Life Sciences ; Medical Biochemistry ; Microfilament Proteins - genetics ; Microfilament Proteins - metabolism ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Non-coding RNA ; Oncology ; Ovarian cancer ; Ovarian Neoplasms - genetics ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Western blotting ; Women ; Womens health ; Wound healing</subject><ispartof>Molecular and cellular biochemistry, 2022-05, Vol.477 (5), p.1477-1488</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-50890f69c0d8a579119acf318ff9fd5ec2fbccee44cf73ff78b56f994d6d8a583</citedby><cites>FETCH-LOGICAL-c442t-50890f69c0d8a579119acf318ff9fd5ec2fbccee44cf73ff78b56f994d6d8a583</cites><orcidid>0000-0001-5504-1801</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-022-04382-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-022-04382-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35166986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Qiong</creatorcontrib><creatorcontrib>Wang, Ling-Xiong</creatorcontrib><creatorcontrib>Zhang, Chun-Yan</creatorcontrib><creatorcontrib>Bai, Nan</creatorcontrib><creatorcontrib>Feng, Chen</creatorcontrib><creatorcontrib>Zhang, Zhuo-Mei</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><creatorcontrib>Gao, Zhen-Zhen</creatorcontrib><title>LncRNA CRNDE promotes cell proliferation, migration and invasion of ovarian cancer via miR-423-5p/FSCN1 axis</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>Ovarian cancer seriously threatens the health of women. LncRNA CRNDE is known to be upregulated in ovarian cancer. However, the mechanism by which CRNDE regulates the progress of ovarian cancer is largely unknown. MTT assay was applied to measure the cell viability. Colony formation assay was used to measure the cell proliferation. Cell migration was tested by wound healing, and Transwell assay was performed to detect cell invasion. In addition, the expression of miR-423-5p, CRNDE and FSCN1 were detected by RT-qPCR and western blotting, respectively. Meanwhile, dual-luciferase reporter assay and RIP assay were performed to explore the correlation between miR-423-5p and CRNDE (or FSCN1). CRNDE and FSCN1 were upregulated in ovarian cancer cells (SKOV3, CAOV-3, IGROV1, A2780 and C13K), while miR-423-5p was downregulated. Moreover, silencing of FSCN1/CRNDE significantly decreased proliferation, migration and invasion of ovarian cancer cells (SKOV3 and CI3K) via suppressing MMP-2 and MMP-9. In addition, CRNDE could sponge miR-423-5p, and FSCN1 was confirmed to be the direct target of miR-423-5p. Furthermore, CRNDE knockdown-induced inhibition of FSCN1 was notably reversed by miR-423-5p downregulation. Knockdown of CRNDE inhibited cell proliferation, migration and invasion of ovarian cancer via miR-423-5p/FSCN1 axis. Thus, CRNDE may serve a new target for ovarian cancer.</description><subject>Assaying</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer</subject><subject>Carcinoma, Ovarian Epithelial - genetics</subject><subject>Cardiology</subject><subject>Carrier Proteins - genetics</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement - genetics</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - genetics</subject><subject>Cell viability</subject><subject>Female</subject><subject>Gelatinase A</subject><subject>Gelatinase B</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Medical Biochemistry</subject><subject>Microfilament Proteins - genetics</subject><subject>Microfilament Proteins - metabolism</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Non-coding RNA</subject><subject>Oncology</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - genetics</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Western blotting</subject><subject>Women</subject><subject>Womens health</subject><subject>Wound healing</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kUtvEzEUhUcIRNPCH2CBLLFhUbd-jR_LKLSAFAUpwNpyPHbkasYO9iQq_x4PU6hACHlh3-vvXN2j0zSvMLrCCInrgjHCCCJCIGJUEiifNAvcCgqZwupps0AUISixEGfNeSl3qNII4-fNGW0x50ryRdOvo91ulmC13by7AYechjS6Aqzr-6nqg3fZjCHFSzCE_fwEJnYgxJMpU5E8SCeTg4nAmmhdBqdgKryFjFDYHq5vP682GJj7UF40z7zpi3v5cF80X29vvqw-wPWn9x9XyzW0jJERtkgq5LmyqJOmFQpjZaynWHqvfNc6S_zOWucYs15Q74XctdwrxTo-CSS9aN7Oc6uDb0dXRj2EMlky0aVj0YQThTgSglT0zV_oXTrmWLerFBOKScn5I7U3vdMh-jRmY6ehesmVkoS2SFXq6h9UPZ0bgk3R-VD7fwjILLA5lZKd14ccBpO_a4z0FLGeI9Y1Yv0zYj2Ze_2w8XE3uO635FemFaAzUOpX3Lv8aOk_Y38AJ9quIQ</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Wang, Qiong</creator><creator>Wang, Ling-Xiong</creator><creator>Zhang, Chun-Yan</creator><creator>Bai, Nan</creator><creator>Feng, Chen</creator><creator>Zhang, Zhuo-Mei</creator><creator>Wang, Liang</creator><creator>Gao, Zhen-Zhen</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5504-1801</orcidid></search><sort><creationdate>20220501</creationdate><title>LncRNA CRNDE promotes cell proliferation, migration and invasion of ovarian cancer via miR-423-5p/FSCN1 axis</title><author>Wang, Qiong ; Wang, Ling-Xiong ; Zhang, Chun-Yan ; Bai, Nan ; Feng, Chen ; Zhang, Zhuo-Mei ; Wang, Liang ; Gao, Zhen-Zhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-50890f69c0d8a579119acf318ff9fd5ec2fbccee44cf73ff78b56f994d6d8a583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Assaying</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cancer</topic><topic>Carcinoma, Ovarian Epithelial - genetics</topic><topic>Cardiology</topic><topic>Carrier Proteins - genetics</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell Movement - genetics</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - genetics</topic><topic>Cell viability</topic><topic>Female</topic><topic>Gelatinase A</topic><topic>Gelatinase B</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Medical Biochemistry</topic><topic>Microfilament Proteins - genetics</topic><topic>Microfilament Proteins - metabolism</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Non-coding RNA</topic><topic>Oncology</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - genetics</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Western blotting</topic><topic>Women</topic><topic>Womens health</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Qiong</creatorcontrib><creatorcontrib>Wang, Ling-Xiong</creatorcontrib><creatorcontrib>Zhang, Chun-Yan</creatorcontrib><creatorcontrib>Bai, Nan</creatorcontrib><creatorcontrib>Feng, Chen</creatorcontrib><creatorcontrib>Zhang, Zhuo-Mei</creatorcontrib><creatorcontrib>Wang, Liang</creatorcontrib><creatorcontrib>Gao, Zhen-Zhen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Qiong</au><au>Wang, Ling-Xiong</au><au>Zhang, Chun-Yan</au><au>Bai, Nan</au><au>Feng, Chen</au><au>Zhang, Zhuo-Mei</au><au>Wang, Liang</au><au>Gao, Zhen-Zhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LncRNA CRNDE promotes cell proliferation, migration and invasion of ovarian cancer via miR-423-5p/FSCN1 axis</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>477</volume><issue>5</issue><spage>1477</spage><epage>1488</epage><pages>1477-1488</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>Ovarian cancer seriously threatens the health of women. LncRNA CRNDE is known to be upregulated in ovarian cancer. However, the mechanism by which CRNDE regulates the progress of ovarian cancer is largely unknown. MTT assay was applied to measure the cell viability. Colony formation assay was used to measure the cell proliferation. Cell migration was tested by wound healing, and Transwell assay was performed to detect cell invasion. In addition, the expression of miR-423-5p, CRNDE and FSCN1 were detected by RT-qPCR and western blotting, respectively. Meanwhile, dual-luciferase reporter assay and RIP assay were performed to explore the correlation between miR-423-5p and CRNDE (or FSCN1). CRNDE and FSCN1 were upregulated in ovarian cancer cells (SKOV3, CAOV-3, IGROV1, A2780 and C13K), while miR-423-5p was downregulated. Moreover, silencing of FSCN1/CRNDE significantly decreased proliferation, migration and invasion of ovarian cancer cells (SKOV3 and CI3K) via suppressing MMP-2 and MMP-9. In addition, CRNDE could sponge miR-423-5p, and FSCN1 was confirmed to be the direct target of miR-423-5p. Furthermore, CRNDE knockdown-induced inhibition of FSCN1 was notably reversed by miR-423-5p downregulation. Knockdown of CRNDE inhibited cell proliferation, migration and invasion of ovarian cancer via miR-423-5p/FSCN1 axis. Thus, CRNDE may serve a new target for ovarian cancer.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35166986</pmid><doi>10.1007/s11010-022-04382-8</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5504-1801</orcidid></addata></record> |
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| subjects | Assaying Biochemistry Biomedical and Life Sciences Cancer Carcinoma, Ovarian Epithelial - genetics Cardiology Carrier Proteins - genetics Cell growth Cell Line, Tumor Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Cell viability Female Gelatinase A Gelatinase B Gene Expression Regulation, Neoplastic Health aspects Humans Life Sciences Medical Biochemistry Microfilament Proteins - genetics Microfilament Proteins - metabolism MicroRNAs - genetics MicroRNAs - metabolism Non-coding RNA Oncology Ovarian cancer Ovarian Neoplasms - genetics RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Western blotting Women Womens health Wound healing |
| title | LncRNA CRNDE promotes cell proliferation, migration and invasion of ovarian cancer via miR-423-5p/FSCN1 axis |
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