Radiological Findings in Laryngeal Anterior Commissure Invasion: CT Scan Highlights
Objectives Preoperative anterior commissure (AC) evaluation in glottic cancer is crucial for therapeutic decisions. Endoscopy is often inadequate to precisely detect the presence of cancer in the AC; thus, computed tomography (CT) scan could help. We investigated the relation between AC thickness on...
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| Veröffentlicht in: | The Laryngoscope 2022-12, Vol.132 (12), p.2427-2433 |
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| container_title | The Laryngoscope |
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| creator | Cristalli, Giovanni Vidiri, Antonello Mercante, Giuseppe Ferreli, Fabio De Virgilio, Armando Donelli, Filippo Davì, Luigi Gasparin, Pierpaola Cocco, Patrizia Giudici, Fabiola Boscolo Nata, Francesca |
| description | Objectives
Preoperative anterior commissure (AC) evaluation in glottic cancer is crucial for therapeutic decisions. Endoscopy is often inadequate to precisely detect the presence of cancer in the AC; thus, computed tomography (CT) scan could help. We investigated the relation between AC thickness on CT scan (in mm), AC involvement by cancer at histology, and radiologic signs of anterior paraglottic space (PGS) infiltration.
Study Design
Retrospective observational study.
Methods
An experienced radiologist retrospectively measured AC thickness and identified signs of anterior PGS infiltration on pretreatment contrast‐enhanced CT scans of 80 patients with primary glottic cancer. The gold standard to define the presence of cancer in the AC was histology. The receiver operating characteristic (ROC) curves were used to determine the potential cut‐off values of AC thickness (Youden index method) able to maximize both sensitivity and specificity in identifying the presence of cancer in the AC at histology and PGS infiltration on CT scan.
Results
AC was significantly thicker in patients with cancer in the AC at histology (P |
| doi_str_mv | 10.1002/lary.30060 |
| format | Article |
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Preoperative anterior commissure (AC) evaluation in glottic cancer is crucial for therapeutic decisions. Endoscopy is often inadequate to precisely detect the presence of cancer in the AC; thus, computed tomography (CT) scan could help. We investigated the relation between AC thickness on CT scan (in mm), AC involvement by cancer at histology, and radiologic signs of anterior paraglottic space (PGS) infiltration.
Study Design
Retrospective observational study.
Methods
An experienced radiologist retrospectively measured AC thickness and identified signs of anterior PGS infiltration on pretreatment contrast‐enhanced CT scans of 80 patients with primary glottic cancer. The gold standard to define the presence of cancer in the AC was histology. The receiver operating characteristic (ROC) curves were used to determine the potential cut‐off values of AC thickness (Youden index method) able to maximize both sensitivity and specificity in identifying the presence of cancer in the AC at histology and PGS infiltration on CT scan.
Results
AC was significantly thicker in patients with cancer in the AC at histology (P < .001) and in patients with PGS infiltration on CT scan (P < .001). The cut‐off values to discriminate the presence of cancer at histology and PGS infiltration on CT scan were 3.62 and 2.6 mm, respectively. We found a substantial agreement between anterior PGS infiltration on CT scan and the presence of cancer in the AC at histology (Cohen Kappa: P = .70).
Conclusion
AC thickness and radiologic signs of PGS infiltration on pretreatment CT scan could represent a method to predict the presence of cancer in the AC at histology.
Level of Evidence
4 Laryngoscope, 132:2427–2433, 2022</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.30060</identifier><identifier>PMID: 35166380</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>anterior commissure ; Cancer ; computed tomography scan ; diagnostic imaging ; glottic cancer ; Histology ; Laryngeal cancer ; Laryngoscopy ; Medical imaging</subject><ispartof>The Laryngoscope, 2022-12, Vol.132 (12), p.2427-2433</ispartof><rights>2022 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3570-3c15f04c164008548b2065c4df64f3cf5c685385a467dabef6bd751196bb70d13</citedby><cites>FETCH-LOGICAL-c3570-3c15f04c164008548b2065c4df64f3cf5c685385a467dabef6bd751196bb70d13</cites><orcidid>0000-0002-2156-8434 ; 0000-0003-2066-9572 ; 0000-0003-0738-8223 ; 0000-0003-0758-2376</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.30060$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.30060$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35166380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cristalli, Giovanni</creatorcontrib><creatorcontrib>Vidiri, Antonello</creatorcontrib><creatorcontrib>Mercante, Giuseppe</creatorcontrib><creatorcontrib>Ferreli, Fabio</creatorcontrib><creatorcontrib>De Virgilio, Armando</creatorcontrib><creatorcontrib>Donelli, Filippo</creatorcontrib><creatorcontrib>Davì, Luigi</creatorcontrib><creatorcontrib>Gasparin, Pierpaola</creatorcontrib><creatorcontrib>Cocco, Patrizia</creatorcontrib><creatorcontrib>Giudici, Fabiola</creatorcontrib><creatorcontrib>Boscolo Nata, Francesca</creatorcontrib><title>Radiological Findings in Laryngeal Anterior Commissure Invasion: CT Scan Highlights</title><title>The Laryngoscope</title><addtitle>Laryngoscope</addtitle><description>Objectives
Preoperative anterior commissure (AC) evaluation in glottic cancer is crucial for therapeutic decisions. Endoscopy is often inadequate to precisely detect the presence of cancer in the AC; thus, computed tomography (CT) scan could help. We investigated the relation between AC thickness on CT scan (in mm), AC involvement by cancer at histology, and radiologic signs of anterior paraglottic space (PGS) infiltration.
Study Design
Retrospective observational study.
Methods
An experienced radiologist retrospectively measured AC thickness and identified signs of anterior PGS infiltration on pretreatment contrast‐enhanced CT scans of 80 patients with primary glottic cancer. The gold standard to define the presence of cancer in the AC was histology. The receiver operating characteristic (ROC) curves were used to determine the potential cut‐off values of AC thickness (Youden index method) able to maximize both sensitivity and specificity in identifying the presence of cancer in the AC at histology and PGS infiltration on CT scan.
Results
AC was significantly thicker in patients with cancer in the AC at histology (P < .001) and in patients with PGS infiltration on CT scan (P < .001). The cut‐off values to discriminate the presence of cancer at histology and PGS infiltration on CT scan were 3.62 and 2.6 mm, respectively. We found a substantial agreement between anterior PGS infiltration on CT scan and the presence of cancer in the AC at histology (Cohen Kappa: P = .70).
Conclusion
AC thickness and radiologic signs of PGS infiltration on pretreatment CT scan could represent a method to predict the presence of cancer in the AC at histology.
Level of Evidence
4 Laryngoscope, 132:2427–2433, 2022</description><subject>anterior commissure</subject><subject>Cancer</subject><subject>computed tomography scan</subject><subject>diagnostic imaging</subject><subject>glottic cancer</subject><subject>Histology</subject><subject>Laryngeal cancer</subject><subject>Laryngoscopy</subject><subject>Medical imaging</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLwzAcR4MoOqcXP4AUvIjQ-U_TpK23UZwKA2GboKeQpmmNdIkmq-K3N3PTgwcPIZA8Hj8eQicYRhggueyE-xwRAAY7aIApwXFaFHQXDcIniXOaPB6gQ-9fAHBGKOyjA0IxYySHAZrPRK1tZ1stRRdNtKm1aX2kTTQNVtOq8Do2K-W0dVFpl0vtfe9UdGfehdfWXEXlIppLYaJb3T534az8EdprROfV8fYeoofJ9aK8jaf3N3fleBpLQjOIicS0gVRilgLkNM2rBBiVad2wtCGyoZLllORUpCyrRaUaVtUZxbhgVZVBjckQnW-8r86-9cqveFgnVdcJo2zvecKSAmjBgAX07A_6YntnwjqehCYUSFgRqIsNJZ313qmGvzq9DB04Br5Ozdep-XfqAJ9ulX21VPUv-tM2AHgDfOhOff6j4tPx7Gkj_QL5NYeN</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Cristalli, Giovanni</creator><creator>Vidiri, Antonello</creator><creator>Mercante, Giuseppe</creator><creator>Ferreli, Fabio</creator><creator>De Virgilio, Armando</creator><creator>Donelli, Filippo</creator><creator>Davì, Luigi</creator><creator>Gasparin, Pierpaola</creator><creator>Cocco, Patrizia</creator><creator>Giudici, Fabiola</creator><creator>Boscolo Nata, Francesca</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2156-8434</orcidid><orcidid>https://orcid.org/0000-0003-2066-9572</orcidid><orcidid>https://orcid.org/0000-0003-0738-8223</orcidid><orcidid>https://orcid.org/0000-0003-0758-2376</orcidid></search><sort><creationdate>202212</creationdate><title>Radiological Findings in Laryngeal Anterior Commissure Invasion: CT Scan Highlights</title><author>Cristalli, Giovanni ; Vidiri, Antonello ; Mercante, Giuseppe ; Ferreli, Fabio ; De Virgilio, Armando ; Donelli, Filippo ; Davì, Luigi ; Gasparin, Pierpaola ; Cocco, Patrizia ; Giudici, Fabiola ; Boscolo Nata, Francesca</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3570-3c15f04c164008548b2065c4df64f3cf5c685385a467dabef6bd751196bb70d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>anterior commissure</topic><topic>Cancer</topic><topic>computed tomography scan</topic><topic>diagnostic imaging</topic><topic>glottic cancer</topic><topic>Histology</topic><topic>Laryngeal cancer</topic><topic>Laryngoscopy</topic><topic>Medical imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cristalli, Giovanni</creatorcontrib><creatorcontrib>Vidiri, Antonello</creatorcontrib><creatorcontrib>Mercante, Giuseppe</creatorcontrib><creatorcontrib>Ferreli, Fabio</creatorcontrib><creatorcontrib>De Virgilio, Armando</creatorcontrib><creatorcontrib>Donelli, Filippo</creatorcontrib><creatorcontrib>Davì, Luigi</creatorcontrib><creatorcontrib>Gasparin, Pierpaola</creatorcontrib><creatorcontrib>Cocco, Patrizia</creatorcontrib><creatorcontrib>Giudici, Fabiola</creatorcontrib><creatorcontrib>Boscolo Nata, Francesca</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cristalli, Giovanni</au><au>Vidiri, Antonello</au><au>Mercante, Giuseppe</au><au>Ferreli, Fabio</au><au>De Virgilio, Armando</au><au>Donelli, Filippo</au><au>Davì, Luigi</au><au>Gasparin, Pierpaola</au><au>Cocco, Patrizia</au><au>Giudici, Fabiola</au><au>Boscolo Nata, Francesca</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiological Findings in Laryngeal Anterior Commissure Invasion: CT Scan Highlights</atitle><jtitle>The Laryngoscope</jtitle><addtitle>Laryngoscope</addtitle><date>2022-12</date><risdate>2022</risdate><volume>132</volume><issue>12</issue><spage>2427</spage><epage>2433</epage><pages>2427-2433</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives
Preoperative anterior commissure (AC) evaluation in glottic cancer is crucial for therapeutic decisions. Endoscopy is often inadequate to precisely detect the presence of cancer in the AC; thus, computed tomography (CT) scan could help. We investigated the relation between AC thickness on CT scan (in mm), AC involvement by cancer at histology, and radiologic signs of anterior paraglottic space (PGS) infiltration.
Study Design
Retrospective observational study.
Methods
An experienced radiologist retrospectively measured AC thickness and identified signs of anterior PGS infiltration on pretreatment contrast‐enhanced CT scans of 80 patients with primary glottic cancer. The gold standard to define the presence of cancer in the AC was histology. The receiver operating characteristic (ROC) curves were used to determine the potential cut‐off values of AC thickness (Youden index method) able to maximize both sensitivity and specificity in identifying the presence of cancer in the AC at histology and PGS infiltration on CT scan.
Results
AC was significantly thicker in patients with cancer in the AC at histology (P < .001) and in patients with PGS infiltration on CT scan (P < .001). The cut‐off values to discriminate the presence of cancer at histology and PGS infiltration on CT scan were 3.62 and 2.6 mm, respectively. We found a substantial agreement between anterior PGS infiltration on CT scan and the presence of cancer in the AC at histology (Cohen Kappa: P = .70).
Conclusion
AC thickness and radiologic signs of PGS infiltration on pretreatment CT scan could represent a method to predict the presence of cancer in the AC at histology.
Level of Evidence
4 Laryngoscope, 132:2427–2433, 2022</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>35166380</pmid><doi>10.1002/lary.30060</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2156-8434</orcidid><orcidid>https://orcid.org/0000-0003-2066-9572</orcidid><orcidid>https://orcid.org/0000-0003-0738-8223</orcidid><orcidid>https://orcid.org/0000-0003-0758-2376</orcidid></addata></record> |
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| subjects | anterior commissure Cancer computed tomography scan diagnostic imaging glottic cancer Histology Laryngeal cancer Laryngoscopy Medical imaging |
| title | Radiological Findings in Laryngeal Anterior Commissure Invasion: CT Scan Highlights |
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