Medicinal chemistry strategies to extend duration of action of inhaled drugs for intracellular targets

[Display omitted] Prolonging duration of action of inhaled drugs is a challenging endeavor and guidance for medicinal chemistry teams is very limited, particularly if the site of action is intracellular. Herein, we identified recent literature reports of newly designed inhaled compounds with intrace...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2022-04, Vol.62, p.128627-128627, Article 128627
Hauptverfasser:	Samy, Karen E., Gampe, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry, Pharmaceutical Drug design Duration of action Inhaled drugs Intracellular targets Pharmacokinetics Pulmonary
Online-Zugang:	Volltext
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