Medicinal chemistry strategies to extend duration of action of inhaled drugs for intracellular targets
[Display omitted] Prolonging duration of action of inhaled drugs is a challenging endeavor and guidance for medicinal chemistry teams is very limited, particularly if the site of action is intracellular. Herein, we identified recent literature reports of newly designed inhaled compounds with intrace...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2022-04, Vol.62, p.128627-128627, Article 128627 |
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| container_end_page | 128627 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 62 |
| creator | Samy, Karen E. Gampe, Christian |
| description | [Display omitted]
Prolonging duration of action of inhaled drugs is a challenging endeavor and guidance for medicinal chemistry teams is very limited, particularly if the site of action is intracellular. Herein, we identified recent literature reports of newly designed inhaled compounds with intracellular targets and summarized learnings from different approaches and strategies undertaken by medicinal chemistry teams. We highlight key properties that have shown to lead to longer duration of action and provide guidance on the best strategy to follow while designing a new inhaled drug with an intracellular target. |
| doi_str_mv | 10.1016/j.bmcl.2022.128627 |
| format | Article |
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Prolonging duration of action of inhaled drugs is a challenging endeavor and guidance for medicinal chemistry teams is very limited, particularly if the site of action is intracellular. Herein, we identified recent literature reports of newly designed inhaled compounds with intracellular targets and summarized learnings from different approaches and strategies undertaken by medicinal chemistry teams. We highlight key properties that have shown to lead to longer duration of action and provide guidance on the best strategy to follow while designing a new inhaled drug with an intracellular target.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2022.128627</identifier><identifier>PMID: 35158043</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Chemistry, Pharmaceutical ; Drug design ; Duration of action ; Inhaled drugs ; Intracellular targets ; Pharmacokinetics ; Pulmonary</subject><ispartof>Bioorganic & medicinal chemistry letters, 2022-04, Vol.62, p.128627-128627, Article 128627</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-e5e7c72e7cae26c71da7df370725f77cb20231de33968ec252139d1d35bfd41e3</citedby><cites>FETCH-LOGICAL-c356t-e5e7c72e7cae26c71da7df370725f77cb20231de33968ec252139d1d35bfd41e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2022.128627$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35158043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samy, Karen E.</creatorcontrib><creatorcontrib>Gampe, Christian</creatorcontrib><title>Medicinal chemistry strategies to extend duration of action of inhaled drugs for intracellular targets</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>[Display omitted]
Prolonging duration of action of inhaled drugs is a challenging endeavor and guidance for medicinal chemistry teams is very limited, particularly if the site of action is intracellular. Herein, we identified recent literature reports of newly designed inhaled compounds with intracellular targets and summarized learnings from different approaches and strategies undertaken by medicinal chemistry teams. We highlight key properties that have shown to lead to longer duration of action and provide guidance on the best strategy to follow while designing a new inhaled drug with an intracellular target.</description><subject>Chemistry, Pharmaceutical</subject><subject>Drug design</subject><subject>Duration of action</subject><subject>Inhaled drugs</subject><subject>Intracellular targets</subject><subject>Pharmacokinetics</subject><subject>Pulmonary</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotlb_gAvJ0s3UPCcdcCPiCypuFNyFNLnTpkxnapIR--9NaevSzU24OeeQ8yF0ScmYElreLMezlW3GjDA2pmxSMnWEhlSUouCCyGM0JFVJikklPgfoLMYlIVQQIU7RgEsqJ0TwIapfwXnrW9Ngu4CVjylscB4mwdxDxKnD8JOgddj1eem7Fnc1NvZw8-3CNJBfQz-PuO5C3mS3habpGxNwMmEOKZ6jk9o0ES725wh9PD683z8X07enl_u7aWG5LFMBEpRVLA8DrLSKOqNczRVRTNZK2VnuyqkDzqtyApZJRnnlqONyVjtBgY_Q9S53HbqvHmLSudL2M6aFro-alawiUnFRZSnbSW3oYgxQ63XwKxM2mhK95auXestXb_nqHd9sutrn97MVuD_LAWgW3O4EkFt-ewg6Wg-tzZQD2KRd5__L_wWeG42c</recordid><startdate>20220415</startdate><enddate>20220415</enddate><creator>Samy, Karen E.</creator><creator>Gampe, Christian</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220415</creationdate><title>Medicinal chemistry strategies to extend duration of action of inhaled drugs for intracellular targets</title><author>Samy, Karen E. ; Gampe, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-e5e7c72e7cae26c71da7df370725f77cb20231de33968ec252139d1d35bfd41e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Chemistry, Pharmaceutical</topic><topic>Drug design</topic><topic>Duration of action</topic><topic>Inhaled drugs</topic><topic>Intracellular targets</topic><topic>Pharmacokinetics</topic><topic>Pulmonary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samy, Karen E.</creatorcontrib><creatorcontrib>Gampe, Christian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samy, Karen E.</au><au>Gampe, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medicinal chemistry strategies to extend duration of action of inhaled drugs for intracellular targets</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2022-04-15</date><risdate>2022</risdate><volume>62</volume><spage>128627</spage><epage>128627</epage><pages>128627-128627</pages><artnum>128627</artnum><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>[Display omitted]
Prolonging duration of action of inhaled drugs is a challenging endeavor and guidance for medicinal chemistry teams is very limited, particularly if the site of action is intracellular. Herein, we identified recent literature reports of newly designed inhaled compounds with intracellular targets and summarized learnings from different approaches and strategies undertaken by medicinal chemistry teams. We highlight key properties that have shown to lead to longer duration of action and provide guidance on the best strategy to follow while designing a new inhaled drug with an intracellular target.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>35158043</pmid><doi>10.1016/j.bmcl.2022.128627</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Bioorganic & medicinal chemistry letters, 2022-04, Vol.62, p.128627-128627, Article 128627 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Chemistry, Pharmaceutical Drug design Duration of action Inhaled drugs Intracellular targets Pharmacokinetics Pulmonary |
| title | Medicinal chemistry strategies to extend duration of action of inhaled drugs for intracellular targets |
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