The Continued Rise of Venous Thromboembolism Across US Children's Hospitals
In 2009, a large multicenter study demonstrated that the rate of pediatric venous thromboembolism (VTE) across US children's hospitals had significantly increased from 2001 to 2007. The objective of this study was to evaluate the rate of pediatric VTE from 2008 to 2019 using similar methodology...
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| Veröffentlicht in: | Pediatrics (Evanston) 2022-03, Vol.149 (3), p.24-24 |
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| creator | O'Brien, Sarah H Stanek, Joseph R Witmer, Char M Raffini, Leslie |
| description | In 2009, a large multicenter study demonstrated that the rate of pediatric venous thromboembolism (VTE) across US children's hospitals had significantly increased from 2001 to 2007. The objective of this study was to evaluate the rate of pediatric VTE from 2008 to 2019 using similar methodology.
A retrospective cohort study using the Pediatric Health Information System (PHIS) database. Subjects from birth to |
| doi_str_mv | 10.1542/peds.2021-054649 |
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A retrospective cohort study using the Pediatric Health Information System (PHIS) database. Subjects from birth to <18 years admitted from 2008 through 2019 who had an ICD-9-CM or ICD-10-CM code for VTE were included. Demographics, underling medical comorbidities and mortality were collected. VTE location and anticoagulation data during admission were extracted.
During the 12-year study period, there were 52 401 hospital admissions among 39 713 pediatric patients with a diagnosis of VTE. The VTE admission rate increased from 46 VTE cases per 10 000 admissions in 2008 to 106 VTE cases per 10 000 admissions in 2019, a 130% increase (P < .0001) in VTE events. The median age at admission was 6.1 years, and almost one-third (31.3%) of patients with VTE were in the adolescent age group (13-17 years). Most patients (78%) had an underlying chronic medical condition.
The rate of VTE in hospitalized pediatric patients continues to increase from a 70% increase reported from 2001 to 2007 to the 130% increase from 2008 to 2019. These findings support the need for more effective VTE prevention strategies. Clinical trials focused on risk stratification and VTE prevention are needed.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2021-054649</identifier><identifier>PMID: 35156127</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Adolescent ; Child ; Children ; Clinical trials ; Databases, Factual ; Demography ; Diseases ; Hospitalization ; Hospitals ; Hospitals, Pediatric ; Humans ; Patients ; Pediatric diseases ; Pediatrics ; Retrospective Studies ; Risk Factors ; Statistics ; Thromboembolism ; Thromboembolism in children ; Venous Thromboembolism - epidemiology</subject><ispartof>Pediatrics (Evanston), 2022-03, Vol.149 (3), p.24-24</ispartof><rights>Copyright © 2022 by the American Academy of Pediatrics.</rights><rights>COPYRIGHT 2022 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Mar 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-f290628bab30bc4f6b6a84b1c75f2c54956d80b5aa5575d2dc199a012f27aecc3</citedby><cites>FETCH-LOGICAL-c473t-f290628bab30bc4f6b6a84b1c75f2c54956d80b5aa5575d2dc199a012f27aecc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35156127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Brien, Sarah H</creatorcontrib><creatorcontrib>Stanek, Joseph R</creatorcontrib><creatorcontrib>Witmer, Char M</creatorcontrib><creatorcontrib>Raffini, Leslie</creatorcontrib><title>The Continued Rise of Venous Thromboembolism Across US Children's Hospitals</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>In 2009, a large multicenter study demonstrated that the rate of pediatric venous thromboembolism (VTE) across US children's hospitals had significantly increased from 2001 to 2007. The objective of this study was to evaluate the rate of pediatric VTE from 2008 to 2019 using similar methodology.
A retrospective cohort study using the Pediatric Health Information System (PHIS) database. Subjects from birth to <18 years admitted from 2008 through 2019 who had an ICD-9-CM or ICD-10-CM code for VTE were included. Demographics, underling medical comorbidities and mortality were collected. VTE location and anticoagulation data during admission were extracted.
During the 12-year study period, there were 52 401 hospital admissions among 39 713 pediatric patients with a diagnosis of VTE. The VTE admission rate increased from 46 VTE cases per 10 000 admissions in 2008 to 106 VTE cases per 10 000 admissions in 2019, a 130% increase (P < .0001) in VTE events. The median age at admission was 6.1 years, and almost one-third (31.3%) of patients with VTE were in the adolescent age group (13-17 years). Most patients (78%) had an underlying chronic medical condition.
The rate of VTE in hospitalized pediatric patients continues to increase from a 70% increase reported from 2001 to 2007 to the 130% increase from 2008 to 2019. These findings support the need for more effective VTE prevention strategies. Clinical trials focused on risk stratification and VTE prevention are needed.</description><subject>Adolescent</subject><subject>Child</subject><subject>Children</subject><subject>Clinical trials</subject><subject>Databases, Factual</subject><subject>Demography</subject><subject>Diseases</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Hospitals, Pediatric</subject><subject>Humans</subject><subject>Patients</subject><subject>Pediatric diseases</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Statistics</subject><subject>Thromboembolism</subject><subject>Thromboembolism in children</subject><subject>Venous Thromboembolism - epidemiology</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1v1DAQhi0EotvCnROyxAEuKeOPsZPjKioUUakSbLlajjPppkriJU4k-Pd4u4UDh9Fcnnf0ah7G3gi4FKjlxwO16VKCFAWgNrp6xjYCqrLQ0uJztgFQotAAeMbOU3oAAI1WvmRnCgUaIe2Gfd3tiddxWvpppZZ_6xPx2PEfNMU18d1-jmMTKc_Qp5FvwxxT4nffeb3vh3am6X3i1zEd-sUP6RV70eVFr5_2Bbv7dLWrr4ub289f6u1NEbRVS9HJCowsG98oaILuTGN8qRsRLHYyoK7QtCU06D2ixVa2QVSVByE7aT2FoC7Yh9Pdwxx_rpQWN_Yp0DD4iXJrJ_N1UxppdUbf_Yc-xHWecrtMKUQl0VaZKk7UvR_I9VPI_6BfS4jDQPfkcvn61m2tMmBspU3m4cQ_vmOmzh3mfvTzbyfAHcW4oxh3FONOYnLk7VORtRmp_Rf4a0L9AdUBh20</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>O'Brien, Sarah H</creator><creator>Stanek, Joseph R</creator><creator>Witmer, Char M</creator><creator>Raffini, Leslie</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20220301</creationdate><title>The Continued Rise of Venous Thromboembolism Across US Children's Hospitals</title><author>O'Brien, Sarah H ; Stanek, Joseph R ; Witmer, Char M ; Raffini, Leslie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-f290628bab30bc4f6b6a84b1c75f2c54956d80b5aa5575d2dc199a012f27aecc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Children</topic><topic>Clinical trials</topic><topic>Databases, Factual</topic><topic>Demography</topic><topic>Diseases</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Hospitals, Pediatric</topic><topic>Humans</topic><topic>Patients</topic><topic>Pediatric diseases</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Statistics</topic><topic>Thromboembolism</topic><topic>Thromboembolism in children</topic><topic>Venous Thromboembolism - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Brien, Sarah H</creatorcontrib><creatorcontrib>Stanek, Joseph R</creatorcontrib><creatorcontrib>Witmer, Char M</creatorcontrib><creatorcontrib>Raffini, Leslie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Brien, Sarah H</au><au>Stanek, Joseph R</au><au>Witmer, Char M</au><au>Raffini, Leslie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Continued Rise of Venous Thromboembolism Across US Children's Hospitals</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>149</volume><issue>3</issue><spage>24</spage><epage>24</epage><pages>24-24</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>In 2009, a large multicenter study demonstrated that the rate of pediatric venous thromboembolism (VTE) across US children's hospitals had significantly increased from 2001 to 2007. The objective of this study was to evaluate the rate of pediatric VTE from 2008 to 2019 using similar methodology.
A retrospective cohort study using the Pediatric Health Information System (PHIS) database. Subjects from birth to <18 years admitted from 2008 through 2019 who had an ICD-9-CM or ICD-10-CM code for VTE were included. Demographics, underling medical comorbidities and mortality were collected. VTE location and anticoagulation data during admission were extracted.
During the 12-year study period, there were 52 401 hospital admissions among 39 713 pediatric patients with a diagnosis of VTE. The VTE admission rate increased from 46 VTE cases per 10 000 admissions in 2008 to 106 VTE cases per 10 000 admissions in 2019, a 130% increase (P < .0001) in VTE events. The median age at admission was 6.1 years, and almost one-third (31.3%) of patients with VTE were in the adolescent age group (13-17 years). Most patients (78%) had an underlying chronic medical condition.
The rate of VTE in hospitalized pediatric patients continues to increase from a 70% increase reported from 2001 to 2007 to the 130% increase from 2008 to 2019. These findings support the need for more effective VTE prevention strategies. Clinical trials focused on risk stratification and VTE prevention are needed.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>35156127</pmid><doi>10.1542/peds.2021-054649</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Child Children Clinical trials Databases, Factual Demography Diseases Hospitalization Hospitals Hospitals, Pediatric Humans Patients Pediatric diseases Pediatrics Retrospective Studies Risk Factors Statistics Thromboembolism Thromboembolism in children Venous Thromboembolism - epidemiology |
| title | The Continued Rise of Venous Thromboembolism Across US Children's Hospitals |
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