Design, Synthesis, in Vitro, and in Silico Evaluation of N‐Phenylacetamide‐Oxindole‐Thiosemicarbazide Hybrids as New Potential Tyrosinase Inhibitors

A novel series of N‐phenylacetamide‐oxindole‐thiosemicarbazide hybrids were synthesized and evaluated for their tyrosinase inhibitory activity. According to tyrosinase inhibition results, all the synthesized compounds showed high tyrosinase inhibitory activity with IC50 values ranging from 0.8 to 3....

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Veröffentlicht in:	Chemistry & biodiversity 2022-04, Vol.19 (4), p.e202100666-n/a
Hauptverfasser:	Yari Boroujeni, Shahriar, Haghighijoo, Zahra, Mohammadi‐Khanaposhtani, Maryam, Mosadeghkhah, Ali, Moazzam, Ali, Yavari, Ali, Hajimahmoodi, Manan, Sabourian, Reyhaneh, Hosseini, Samesadat, Larijani, Bagher, Hamedifar, Halleh, Ansari, Samira, Mahdavi, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetanilide Agaricales docking Enzyme Inhibitors - chemistry Histidine Hybrids in vitro Kinetics Kojic acid Molecular Docking Simulation Molecular Structure Monophenol Monooxygenase N-phenylacetamide oxindole Oxindoles Semicarbazides Structure-Activity Relationship Synthesis thiosemicarbazide Thiosemicarbazides Tyrosinase
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