DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity

HIGD1A is an important mitochondrial protein recently shown to have a novel nuclear localization under severe stress. However, whether this protein is also associated with the DNA damage response has rarely been studied. Here, we reported that DSBs-induced the translocation of mitochondrial HIGD1A t...

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Veröffentlicht in:Oncogene 2022-03, Vol.41 (13), p.1918-1930
Hauptverfasser: Chen, Bin, Xu, Feng, Gao, Yang, Hu, Guanshuo, Zhu, Kaili, Lu, Huayi, Xu, An, Chen, Shaopeng, Wu, Lijun, Zhao, Guoping
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Sprache:eng
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