Outcomes during delivery hospitalisations with inflammatory bowel disease
Objective To characterise inflammatory bowel disease (IBD) trends and associated risk during delivery hospitalisations. Design Cross‐sectional. Setting US delivery hospitalisations. Population Delivery hospitalisations in the 2000–2018 National Inpatient Sample. Methods This study analysed a nationa...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2022-06, Vol.129 (7), p.1073-1083 |
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| creator | Yu, K. Faye, A. S. Wen, T Guglielminotti, J. R. Huang, Y. Wright, J. D. D’Alton, M. E. Friedman, A. M. |
| description | Objective
To characterise inflammatory bowel disease (IBD) trends and associated risk during delivery hospitalisations.
Design
Cross‐sectional.
Setting
US delivery hospitalisations.
Population
Delivery hospitalisations in the 2000–2018 National Inpatient Sample.
Methods
This study analysed a nationally representative hospital discharge database based on the presence of IBD. Temporal trends in IBD were analysed using joinpoint regression to estimate the average annual percent change (AAPC). IBD severity was characterised by the presence of diagnoses such as penetrating and stricturing disease and history of bowel resection. Risks for adverse outcomes were analysed based on presence of IBD. Poisson regression models were performed with unadjusted and adjusted risk ratios (aRR) as measures of effect.
Main Outcome Measure
Prevalence of IBD and associated adverse outcomes.
Results
Of 73 109 790 delivery hospitalisations, 89 965 had a diagnosis of IBD. IBD rose from 0.06% in 2000 to 0.21% in 2018 (AAPC 7.3%, 95% CI 6.7–7.9%). Among deliveries with IBD, IBD severity diagnoses increased from 4.1% to 8.1% from 2000 to 2018. In adjusted analysis, IBD was associated with increased risk for preterm delivery (aRR 1.50, 95% CI 1.47–1.53), severe maternal morbidity (aRR 1.93, 95% CI 1.83–2.04), venous thrombo‐embolism (aRR 2.76, 95% CI 2.39–3.18) and surgical injury during caesarean delivery hospitalisation (aRR 5.03, 95% CI 4.76–5.31). In the presence of a severe IBD diagnosis, risk was further increased for all adverse outcomes.
Conclusion
IBD is increasing in the obstetric population and is associated with adverse outcomes. Risk is increased in the presence of a severe IBD diagnosis.
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Deliveries among women with inflammatory bowel disease are increasing. Disease severity is associated with adverse outcomes.
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Deliveries among women with inflammatory bowel disease are increasing. Disease severity is associated with adverse outcomes. |
| doi_str_mv | 10.1111/1471-0528.17039 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2628677356</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2628677356</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3719-c5006e2efdc9784924eba36a16427ddac7f82e4e8e001732e8536e11c7329e5a3</originalsourceid><addsrcrecordid>eNqFkD1PwzAQhi0EoqUws6FILCxp_e1khIpPVeoCs-UmF-oqiUucUPXf4zalAwu33On03KvTg9A1wWMSakK4IjEWNBkThVl6gobHzel-xjFmNBmgC-9XGBNJMTtHAyaIoIInQ_Q679rMVeCjvGts_RnlUNpvaLbR0vm1bU1pvWmtq320se0ysnVRmqoyrQvIwm2gjHLrwXi4RGeFKT1cHfoIfTw9vk9f4tn8-XV6P4szpkgaZwJjCRSKPEtVwlPKYWGYNERyqvLcZKpIKHBIILyrGIVEMAmEZGFOQRg2Qnd97rpxXx34VlfWZ1CWpgbXeU0lTaRSTMiA3v5BV65r6vBdoCRPUyYwD9Skp7LGed9AodeNrUyz1QTrnWW9c6p3TvXecri4OeR2iwryI_-rNQCiBza2hO1_efrhbd4H_wCnuYYm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2664993504</pqid></control><display><type>article</type><title>Outcomes during delivery hospitalisations with inflammatory bowel disease</title><source>Wiley Online Library All Journals</source><creator>Yu, K. ; Faye, A. S. ; Wen, T ; Guglielminotti, J. R. ; Huang, Y. ; Wright, J. D. ; D’Alton, M. E. ; Friedman, A. M.</creator><creatorcontrib>Yu, K. ; Faye, A. S. ; Wen, T ; Guglielminotti, J. R. ; Huang, Y. ; Wright, J. D. ; D’Alton, M. E. ; Friedman, A. M.</creatorcontrib><description>Objective
To characterise inflammatory bowel disease (IBD) trends and associated risk during delivery hospitalisations.
Design
Cross‐sectional.
Setting
US delivery hospitalisations.
Population
Delivery hospitalisations in the 2000–2018 National Inpatient Sample.
Methods
This study analysed a nationally representative hospital discharge database based on the presence of IBD. Temporal trends in IBD were analysed using joinpoint regression to estimate the average annual percent change (AAPC). IBD severity was characterised by the presence of diagnoses such as penetrating and stricturing disease and history of bowel resection. Risks for adverse outcomes were analysed based on presence of IBD. Poisson regression models were performed with unadjusted and adjusted risk ratios (aRR) as measures of effect.
Main Outcome Measure
Prevalence of IBD and associated adverse outcomes.
Results
Of 73 109 790 delivery hospitalisations, 89 965 had a diagnosis of IBD. IBD rose from 0.06% in 2000 to 0.21% in 2018 (AAPC 7.3%, 95% CI 6.7–7.9%). Among deliveries with IBD, IBD severity diagnoses increased from 4.1% to 8.1% from 2000 to 2018. In adjusted analysis, IBD was associated with increased risk for preterm delivery (aRR 1.50, 95% CI 1.47–1.53), severe maternal morbidity (aRR 1.93, 95% CI 1.83–2.04), venous thrombo‐embolism (aRR 2.76, 95% CI 2.39–3.18) and surgical injury during caesarean delivery hospitalisation (aRR 5.03, 95% CI 4.76–5.31). In the presence of a severe IBD diagnosis, risk was further increased for all adverse outcomes.
Conclusion
IBD is increasing in the obstetric population and is associated with adverse outcomes. Risk is increased in the presence of a severe IBD diagnosis.
Tweetable
Deliveries among women with inflammatory bowel disease are increasing. Disease severity is associated with adverse outcomes.
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Deliveries among women with inflammatory bowel disease are increasing. Disease severity is associated with adverse outcomes.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/1471-0528.17039</identifier><identifier>PMID: 35152548</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Cesarean section ; Childbirth & labor ; Clinical outcomes ; Crohn's disease ; Diagnosis ; Embolism ; Epidemiology ; Hospitalization ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Injuries ; Intestine ; maternal morbidity ; maternal outcomes ; Morbidity ; Premature birth ; Regression analysis ; Thromboembolism ; Trends</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2022-06, Vol.129 (7), p.1073-1083</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>Copyright © 2022 Royal College of Obstetricians and Gynaecologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3719-c5006e2efdc9784924eba36a16427ddac7f82e4e8e001732e8536e11c7329e5a3</citedby><cites>FETCH-LOGICAL-c3719-c5006e2efdc9784924eba36a16427ddac7f82e4e8e001732e8536e11c7329e5a3</cites><orcidid>0000-0001-5015-4110 ; 0000-0002-1749-3142</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1471-0528.17039$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1471-0528.17039$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35152548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, K.</creatorcontrib><creatorcontrib>Faye, A. S.</creatorcontrib><creatorcontrib>Wen, T</creatorcontrib><creatorcontrib>Guglielminotti, J. R.</creatorcontrib><creatorcontrib>Huang, Y.</creatorcontrib><creatorcontrib>Wright, J. D.</creatorcontrib><creatorcontrib>D’Alton, M. E. </creatorcontrib><creatorcontrib>Friedman, A. M.</creatorcontrib><title>Outcomes during delivery hospitalisations with inflammatory bowel disease</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Objective
To characterise inflammatory bowel disease (IBD) trends and associated risk during delivery hospitalisations.
Design
Cross‐sectional.
Setting
US delivery hospitalisations.
Population
Delivery hospitalisations in the 2000–2018 National Inpatient Sample.
Methods
This study analysed a nationally representative hospital discharge database based on the presence of IBD. Temporal trends in IBD were analysed using joinpoint regression to estimate the average annual percent change (AAPC). IBD severity was characterised by the presence of diagnoses such as penetrating and stricturing disease and history of bowel resection. Risks for adverse outcomes were analysed based on presence of IBD. Poisson regression models were performed with unadjusted and adjusted risk ratios (aRR) as measures of effect.
Main Outcome Measure
Prevalence of IBD and associated adverse outcomes.
Results
Of 73 109 790 delivery hospitalisations, 89 965 had a diagnosis of IBD. IBD rose from 0.06% in 2000 to 0.21% in 2018 (AAPC 7.3%, 95% CI 6.7–7.9%). Among deliveries with IBD, IBD severity diagnoses increased from 4.1% to 8.1% from 2000 to 2018. In adjusted analysis, IBD was associated with increased risk for preterm delivery (aRR 1.50, 95% CI 1.47–1.53), severe maternal morbidity (aRR 1.93, 95% CI 1.83–2.04), venous thrombo‐embolism (aRR 2.76, 95% CI 2.39–3.18) and surgical injury during caesarean delivery hospitalisation (aRR 5.03, 95% CI 4.76–5.31). In the presence of a severe IBD diagnosis, risk was further increased for all adverse outcomes.
Conclusion
IBD is increasing in the obstetric population and is associated with adverse outcomes. Risk is increased in the presence of a severe IBD diagnosis.
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Deliveries among women with inflammatory bowel disease are increasing. Disease severity is associated with adverse outcomes.
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Deliveries among women with inflammatory bowel disease are increasing. Disease severity is associated with adverse outcomes.</description><subject>Cesarean section</subject><subject>Childbirth & labor</subject><subject>Clinical outcomes</subject><subject>Crohn's disease</subject><subject>Diagnosis</subject><subject>Embolism</subject><subject>Epidemiology</subject><subject>Hospitalization</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Injuries</subject><subject>Intestine</subject><subject>maternal morbidity</subject><subject>maternal outcomes</subject><subject>Morbidity</subject><subject>Premature birth</subject><subject>Regression analysis</subject><subject>Thromboembolism</subject><subject>Trends</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkD1PwzAQhi0EoqUws6FILCxp_e1khIpPVeoCs-UmF-oqiUucUPXf4zalAwu33On03KvTg9A1wWMSakK4IjEWNBkThVl6gobHzel-xjFmNBmgC-9XGBNJMTtHAyaIoIInQ_Q679rMVeCjvGts_RnlUNpvaLbR0vm1bU1pvWmtq320se0ysnVRmqoyrQvIwm2gjHLrwXi4RGeFKT1cHfoIfTw9vk9f4tn8-XV6P4szpkgaZwJjCRSKPEtVwlPKYWGYNERyqvLcZKpIKHBIILyrGIVEMAmEZGFOQRg2Qnd97rpxXx34VlfWZ1CWpgbXeU0lTaRSTMiA3v5BV65r6vBdoCRPUyYwD9Skp7LGed9AodeNrUyz1QTrnWW9c6p3TvXecri4OeR2iwryI_-rNQCiBza2hO1_efrhbd4H_wCnuYYm</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Yu, K.</creator><creator>Faye, A. S.</creator><creator>Wen, T</creator><creator>Guglielminotti, J. R.</creator><creator>Huang, Y.</creator><creator>Wright, J. D.</creator><creator>D’Alton, M. E. </creator><creator>Friedman, A. M.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5015-4110</orcidid><orcidid>https://orcid.org/0000-0002-1749-3142</orcidid></search><sort><creationdate>202206</creationdate><title>Outcomes during delivery hospitalisations with inflammatory bowel disease</title><author>Yu, K. ; Faye, A. S. ; Wen, T ; Guglielminotti, J. R. ; Huang, Y. ; Wright, J. D. ; D’Alton, M. E. ; Friedman, A. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3719-c5006e2efdc9784924eba36a16427ddac7f82e4e8e001732e8536e11c7329e5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cesarean section</topic><topic>Childbirth & labor</topic><topic>Clinical outcomes</topic><topic>Crohn's disease</topic><topic>Diagnosis</topic><topic>Embolism</topic><topic>Epidemiology</topic><topic>Hospitalization</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Injuries</topic><topic>Intestine</topic><topic>maternal morbidity</topic><topic>maternal outcomes</topic><topic>Morbidity</topic><topic>Premature birth</topic><topic>Regression analysis</topic><topic>Thromboembolism</topic><topic>Trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, K.</creatorcontrib><creatorcontrib>Faye, A. S.</creatorcontrib><creatorcontrib>Wen, T</creatorcontrib><creatorcontrib>Guglielminotti, J. R.</creatorcontrib><creatorcontrib>Huang, Y.</creatorcontrib><creatorcontrib>Wright, J. D.</creatorcontrib><creatorcontrib>D’Alton, M. E. </creatorcontrib><creatorcontrib>Friedman, A. M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, K.</au><au>Faye, A. S.</au><au>Wen, T</au><au>Guglielminotti, J. R.</au><au>Huang, Y.</au><au>Wright, J. D.</au><au>D’Alton, M. E. </au><au>Friedman, A. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes during delivery hospitalisations with inflammatory bowel disease</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2022-06</date><risdate>2022</risdate><volume>129</volume><issue>7</issue><spage>1073</spage><epage>1083</epage><pages>1073-1083</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><abstract>Objective
To characterise inflammatory bowel disease (IBD) trends and associated risk during delivery hospitalisations.
Design
Cross‐sectional.
Setting
US delivery hospitalisations.
Population
Delivery hospitalisations in the 2000–2018 National Inpatient Sample.
Methods
This study analysed a nationally representative hospital discharge database based on the presence of IBD. Temporal trends in IBD were analysed using joinpoint regression to estimate the average annual percent change (AAPC). IBD severity was characterised by the presence of diagnoses such as penetrating and stricturing disease and history of bowel resection. Risks for adverse outcomes were analysed based on presence of IBD. Poisson regression models were performed with unadjusted and adjusted risk ratios (aRR) as measures of effect.
Main Outcome Measure
Prevalence of IBD and associated adverse outcomes.
Results
Of 73 109 790 delivery hospitalisations, 89 965 had a diagnosis of IBD. IBD rose from 0.06% in 2000 to 0.21% in 2018 (AAPC 7.3%, 95% CI 6.7–7.9%). Among deliveries with IBD, IBD severity diagnoses increased from 4.1% to 8.1% from 2000 to 2018. In adjusted analysis, IBD was associated with increased risk for preterm delivery (aRR 1.50, 95% CI 1.47–1.53), severe maternal morbidity (aRR 1.93, 95% CI 1.83–2.04), venous thrombo‐embolism (aRR 2.76, 95% CI 2.39–3.18) and surgical injury during caesarean delivery hospitalisation (aRR 5.03, 95% CI 4.76–5.31). In the presence of a severe IBD diagnosis, risk was further increased for all adverse outcomes.
Conclusion
IBD is increasing in the obstetric population and is associated with adverse outcomes. Risk is increased in the presence of a severe IBD diagnosis.
Tweetable
Deliveries among women with inflammatory bowel disease are increasing. Disease severity is associated with adverse outcomes.
Tweetable
Deliveries among women with inflammatory bowel disease are increasing. Disease severity is associated with adverse outcomes.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35152548</pmid><doi>10.1111/1471-0528.17039</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5015-4110</orcidid><orcidid>https://orcid.org/0000-0002-1749-3142</orcidid></addata></record> |
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| identifier | ISSN: 1470-0328 |
| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2022-06, Vol.129 (7), p.1073-1083 |
| issn | 1470-0328 1471-0528 |
| language | eng |
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| source | Wiley Online Library All Journals |
| subjects | Cesarean section Childbirth & labor Clinical outcomes Crohn's disease Diagnosis Embolism Epidemiology Hospitalization Inflammatory bowel disease Inflammatory bowel diseases Injuries Intestine maternal morbidity maternal outcomes Morbidity Premature birth Regression analysis Thromboembolism Trends |
| title | Outcomes during delivery hospitalisations with inflammatory bowel disease |
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