Calorie restriction potentiates the therapeutic potential of GABA in managing type 2 diabetes in a mouse model

Dysfunctional adipocytes/β-cells advance type 2 diabetes (T2D). Calorie restriction (CR) improves insulin sensitivity and fasting blood glucose (FBG) levels, while γ-aminobutyric acid (GABA) exerts regenerative effects. The impact of therapies was assessed by a high-fat diet (HFD) + streptozotocin (...

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Veröffentlicht in:	Life sciences (1973) 2022-04, Vol.295, p.120382-120382, Article 120382
Hauptverfasser:	Rathwa, Nirali, Parmar, Nishant, Palit, Sayantani Pramanik, Patel, Roma, Bhaskaran, Ravi Sankar, Ramachandran, A.V., Begum, Rasheedunnisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Caloric Restriction Calorie restriction Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 2 - diet therapy Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diet, High-Fat Disease Models, Animal gamma-Aminobutyric Acid - metabolism gamma-Aminobutyric Acid - pharmacology Insulin - metabolism Insulin Resistance - physiology Insulin-Secreting Cells - metabolism Male Mice Mice, Inbred C57BL Obesity Streptozocin - pharmacology Type 2 diabetes β-Cell regeneration γ-Aminobutyric acid
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