DAB2IP suppresses tumor malignancy by inhibiting GRP75-driven p53 ubiquitination in colon cancer

Increasing evidence has shown that DAB2IP acts as a tumor suppressor and plays an inhibitory role in many signals associated with tumorigenesis. However, the underlying mechanism of this function remains unclear. Our study shows that DAB2IP was positively associated with a good prognosis in patients...

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Veröffentlicht in:	Cancer letters 2022-04, Vol.532, p.215588-215588, Article 215588
Hauptverfasser:	Feng, Shengjie, Huang, Qingwen, Deng, Jiao, Jia, Weiyi, Gong, Jianping, Xie, Daxing, Shen, Jie, Liu, Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal research Animals Antibodies Antigens Apoptosis ASK1-Interacting protein Cell cycle Cell Line, Tumor Cell Proliferation Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - genetics Colorectal cancer Colorectal carcinoma Competitive antagonism Degradation Epigenetics Fluorides HSP70 Heat-Shock Proteins Humans Invasiveness Malignancy Mass spectroscopy Membrane Proteins Mortalin Mutagenesis Mutation p53 degradation p53 Protein Plasmids Proteasomes Proteins ras GTPase-Activating Proteins - genetics ras GTPase-Activating Proteins - metabolism Ras-GAP domain Senescence Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumorigenesis Tumors Ubiquitin Ubiquitin - metabolism Ubiquitin-protein ligase Ubiquitination
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