Decoding Insulin-Like Growth Factor Signaling Pathway From a Non-coding RNAs Perspective: A Step Towards Precision Oncology in Breast Cancer
Breast cancer (BC) is a highly complex and heterogenous disease. Several oncogenic signaling pathways drive BC oncogenic activity, thus hindering scientists to unravel the exact molecular pathogenesis of such multifaceted disease. This highlights the urgent need to find a key regulator that tunes up...
Gespeichert in:
| Veröffentlicht in: | Journal of mammary gland biology and neoplasia 2022-03, Vol.27 (1), p.79-99 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 99 |
|---|---|
| container_issue | 1 |
| container_start_page | 79 |
| container_title | Journal of mammary gland biology and neoplasia |
| container_volume | 27 |
| creator | ZeinElAbdeen, Yousra Ahmed AbdAlSeed, Amna Youness, Rana A. |
| description | Breast cancer (BC) is a highly complex and heterogenous disease. Several oncogenic signaling pathways drive BC oncogenic activity, thus hindering scientists to unravel the exact molecular pathogenesis of such multifaceted disease. This highlights the urgent need to find a key regulator that tunes up such intertwined oncogenic drivers to trim the malignant transformation process within the breast tissue. The Insulin-like growth factor (IGF) signaling pathway is a tenacious axis that is heavily intertwined with BC where it modulates the amplitude and activity of vital downstream oncogenic signaling pathways. Yet, the complexity of the pathway and the interactions driven by its different members seem to aggravate its oncogenicity and hinder its target-ability. In this review, the authors shed the light on the stubbornness of the IGF signaling pathway and its potential regulation by non-coding RNAs in different BC subtypes. Nonetheless, this review also spots light on the possible transport systems available for efficient delivery of non-coding RNAs to their respective targets to reach a personalized treatment code for BC patients. |
| doi_str_mv | 10.1007/s10911-022-09511-z |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2628299478</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A705101178</galeid><sourcerecordid>A705101178</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-32f1887ce06d57562941056399bbaf188b8d035f101eb27fd00a2719bfb9c1d23</originalsourceid><addsrcrecordid>eNp9ks9u1DAQxiMEoqXwAhyQJS5cUsbOH8fcloUtlVZtRcvZcpxJ6pLYi52w2j4DD423u20FQsgHjzy_7_OMPUnymsIxBeDvAwVBaQqMpSCKGN0-SQ5pwbOUQyaexhiqLM2A0YPkRQg3ACCqsnieHGQFzcuSicPk1yfUrjG2I6c2TL2x6dJ8R3Li3Xq8JgulR-fJpems6rfQhRqv12pDFt4NRJEzZ9O9_OvZLJAL9GGFejQ_8QOZkcsRV-TKrZVvYs6jNsE4S86tdr3rNsRY8tGjCiOZK6vRv0yetaoP-Gq_HyXfFp-v5l_S5fnJ6Xy2THWeszHNWEurimuEsil4EfvIKRRlJkRdq22qrhrIipYCxZrxtgFQjFNRt7XQtGHZUfJu57vy7seEYZSDCRr7Xll0U5CsZBUTIudVRN_-hd64ycfX2FKl4BWLNz1SnepRGtu60Su9NZUzDkUshN55Hf-DiqvBwWhnsTXx_A8B2wm0dyF4bOXKm0H5jaQgtyMgdyMg4wjIuxGQt1H0Zl_xVA_YPEju_zwC2Q4IMWU79I8t_cf2NwHfuiU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2669782035</pqid></control><display><type>article</type><title>Decoding Insulin-Like Growth Factor Signaling Pathway From a Non-coding RNAs Perspective: A Step Towards Precision Oncology in Breast Cancer</title><source>MEDLINE</source><source>SpringerLink (Online service)</source><creator>ZeinElAbdeen, Yousra Ahmed ; AbdAlSeed, Amna ; Youness, Rana A.</creator><creatorcontrib>ZeinElAbdeen, Yousra Ahmed ; AbdAlSeed, Amna ; Youness, Rana A.</creatorcontrib><description>Breast cancer (BC) is a highly complex and heterogenous disease. Several oncogenic signaling pathways drive BC oncogenic activity, thus hindering scientists to unravel the exact molecular pathogenesis of such multifaceted disease. This highlights the urgent need to find a key regulator that tunes up such intertwined oncogenic drivers to trim the malignant transformation process within the breast tissue. The Insulin-like growth factor (IGF) signaling pathway is a tenacious axis that is heavily intertwined with BC where it modulates the amplitude and activity of vital downstream oncogenic signaling pathways. Yet, the complexity of the pathway and the interactions driven by its different members seem to aggravate its oncogenicity and hinder its target-ability. In this review, the authors shed the light on the stubbornness of the IGF signaling pathway and its potential regulation by non-coding RNAs in different BC subtypes. Nonetheless, this review also spots light on the possible transport systems available for efficient delivery of non-coding RNAs to their respective targets to reach a personalized treatment code for BC patients.</description><identifier>ISSN: 1083-3021</identifier><identifier>EISSN: 1573-7039</identifier><identifier>DOI: 10.1007/s10911-022-09511-z</identifier><identifier>PMID: 35146629</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Antimitotic agents ; Antineoplastic agents ; Breast cancer ; Breast Neoplasms - pathology ; Cancer Research ; Development and progression ; Female ; Humans ; Insulin ; Insulin-like growth factors ; Medicine ; Medicine & Public Health ; Non-coding RNA ; Oncogenes ; Oncology ; Precision Medicine ; Review Paper ; Signal Transduction ; Somatomedins</subject><ispartof>Journal of mammary gland biology and neoplasia, 2022-03, Vol.27 (1), p.79-99</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-32f1887ce06d57562941056399bbaf188b8d035f101eb27fd00a2719bfb9c1d23</citedby><cites>FETCH-LOGICAL-c442t-32f1887ce06d57562941056399bbaf188b8d035f101eb27fd00a2719bfb9c1d23</cites><orcidid>0000-0001-6268-7942</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10911-022-09511-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10911-022-09511-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35146629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZeinElAbdeen, Yousra Ahmed</creatorcontrib><creatorcontrib>AbdAlSeed, Amna</creatorcontrib><creatorcontrib>Youness, Rana A.</creatorcontrib><title>Decoding Insulin-Like Growth Factor Signaling Pathway From a Non-coding RNAs Perspective: A Step Towards Precision Oncology in Breast Cancer</title><title>Journal of mammary gland biology and neoplasia</title><addtitle>J Mammary Gland Biol Neoplasia</addtitle><addtitle>J Mammary Gland Biol Neoplasia</addtitle><description>Breast cancer (BC) is a highly complex and heterogenous disease. Several oncogenic signaling pathways drive BC oncogenic activity, thus hindering scientists to unravel the exact molecular pathogenesis of such multifaceted disease. This highlights the urgent need to find a key regulator that tunes up such intertwined oncogenic drivers to trim the malignant transformation process within the breast tissue. The Insulin-like growth factor (IGF) signaling pathway is a tenacious axis that is heavily intertwined with BC where it modulates the amplitude and activity of vital downstream oncogenic signaling pathways. Yet, the complexity of the pathway and the interactions driven by its different members seem to aggravate its oncogenicity and hinder its target-ability. In this review, the authors shed the light on the stubbornness of the IGF signaling pathway and its potential regulation by non-coding RNAs in different BC subtypes. Nonetheless, this review also spots light on the possible transport systems available for efficient delivery of non-coding RNAs to their respective targets to reach a personalized treatment code for BC patients.</description><subject>Antimitotic agents</subject><subject>Antineoplastic agents</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer Research</subject><subject>Development and progression</subject><subject>Female</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin-like growth factors</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Non-coding RNA</subject><subject>Oncogenes</subject><subject>Oncology</subject><subject>Precision Medicine</subject><subject>Review Paper</subject><subject>Signal Transduction</subject><subject>Somatomedins</subject><issn>1083-3021</issn><issn>1573-7039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ks9u1DAQxiMEoqXwAhyQJS5cUsbOH8fcloUtlVZtRcvZcpxJ6pLYi52w2j4DD423u20FQsgHjzy_7_OMPUnymsIxBeDvAwVBaQqMpSCKGN0-SQ5pwbOUQyaexhiqLM2A0YPkRQg3ACCqsnieHGQFzcuSicPk1yfUrjG2I6c2TL2x6dJ8R3Li3Xq8JgulR-fJpems6rfQhRqv12pDFt4NRJEzZ9O9_OvZLJAL9GGFejQ_8QOZkcsRV-TKrZVvYs6jNsE4S86tdr3rNsRY8tGjCiOZK6vRv0yetaoP-Gq_HyXfFp-v5l_S5fnJ6Xy2THWeszHNWEurimuEsil4EfvIKRRlJkRdq22qrhrIipYCxZrxtgFQjFNRt7XQtGHZUfJu57vy7seEYZSDCRr7Xll0U5CsZBUTIudVRN_-hd64ycfX2FKl4BWLNz1SnepRGtu60Su9NZUzDkUshN55Hf-DiqvBwWhnsTXx_A8B2wm0dyF4bOXKm0H5jaQgtyMgdyMg4wjIuxGQt1H0Zl_xVA_YPEju_zwC2Q4IMWU79I8t_cf2NwHfuiU</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>ZeinElAbdeen, Yousra Ahmed</creator><creator>AbdAlSeed, Amna</creator><creator>Youness, Rana A.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6268-7942</orcidid></search><sort><creationdate>20220301</creationdate><title>Decoding Insulin-Like Growth Factor Signaling Pathway From a Non-coding RNAs Perspective: A Step Towards Precision Oncology in Breast Cancer</title><author>ZeinElAbdeen, Yousra Ahmed ; AbdAlSeed, Amna ; Youness, Rana A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-32f1887ce06d57562941056399bbaf188b8d035f101eb27fd00a2719bfb9c1d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antimitotic agents</topic><topic>Antineoplastic agents</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer Research</topic><topic>Development and progression</topic><topic>Female</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin-like growth factors</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Non-coding RNA</topic><topic>Oncogenes</topic><topic>Oncology</topic><topic>Precision Medicine</topic><topic>Review Paper</topic><topic>Signal Transduction</topic><topic>Somatomedins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZeinElAbdeen, Yousra Ahmed</creatorcontrib><creatorcontrib>AbdAlSeed, Amna</creatorcontrib><creatorcontrib>Youness, Rana A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of mammary gland biology and neoplasia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZeinElAbdeen, Yousra Ahmed</au><au>AbdAlSeed, Amna</au><au>Youness, Rana A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decoding Insulin-Like Growth Factor Signaling Pathway From a Non-coding RNAs Perspective: A Step Towards Precision Oncology in Breast Cancer</atitle><jtitle>Journal of mammary gland biology and neoplasia</jtitle><stitle>J Mammary Gland Biol Neoplasia</stitle><addtitle>J Mammary Gland Biol Neoplasia</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>27</volume><issue>1</issue><spage>79</spage><epage>99</epage><pages>79-99</pages><issn>1083-3021</issn><eissn>1573-7039</eissn><abstract>Breast cancer (BC) is a highly complex and heterogenous disease. Several oncogenic signaling pathways drive BC oncogenic activity, thus hindering scientists to unravel the exact molecular pathogenesis of such multifaceted disease. This highlights the urgent need to find a key regulator that tunes up such intertwined oncogenic drivers to trim the malignant transformation process within the breast tissue. The Insulin-like growth factor (IGF) signaling pathway is a tenacious axis that is heavily intertwined with BC where it modulates the amplitude and activity of vital downstream oncogenic signaling pathways. Yet, the complexity of the pathway and the interactions driven by its different members seem to aggravate its oncogenicity and hinder its target-ability. In this review, the authors shed the light on the stubbornness of the IGF signaling pathway and its potential regulation by non-coding RNAs in different BC subtypes. Nonetheless, this review also spots light on the possible transport systems available for efficient delivery of non-coding RNAs to their respective targets to reach a personalized treatment code for BC patients.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35146629</pmid><doi>10.1007/s10911-022-09511-z</doi><tpages>21</tpages><orcidid>https://orcid.org/0000-0001-6268-7942</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1083-3021 |
| ispartof | Journal of mammary gland biology and neoplasia, 2022-03, Vol.27 (1), p.79-99 |
| issn | 1083-3021 1573-7039 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2628299478 |
| source | MEDLINE; SpringerLink (Online service) |
| subjects | Antimitotic agents Antineoplastic agents Breast cancer Breast Neoplasms - pathology Cancer Research Development and progression Female Humans Insulin Insulin-like growth factors Medicine Medicine & Public Health Non-coding RNA Oncogenes Oncology Precision Medicine Review Paper Signal Transduction Somatomedins |
| title | Decoding Insulin-Like Growth Factor Signaling Pathway From a Non-coding RNAs Perspective: A Step Towards Precision Oncology in Breast Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T07%3A05%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decoding%20Insulin-Like%20Growth%20Factor%20Signaling%20Pathway%20From%20a%20Non-coding%20RNAs%20Perspective:%20A%20Step%20Towards%20Precision%20Oncology%20in%20Breast%20Cancer&rft.jtitle=Journal%20of%20mammary%20gland%20biology%20and%20neoplasia&rft.au=ZeinElAbdeen,%20Yousra%20Ahmed&rft.date=2022-03-01&rft.volume=27&rft.issue=1&rft.spage=79&rft.epage=99&rft.pages=79-99&rft.issn=1083-3021&rft.eissn=1573-7039&rft_id=info:doi/10.1007/s10911-022-09511-z&rft_dat=%3Cgale_proqu%3EA705101178%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2669782035&rft_id=info:pmid/35146629&rft_galeid=A705101178&rfr_iscdi=true |