Microbial resistance: The role of efflux pump superfamilies and their respective substrates
The microorganism resistance to antibiotics has become one of the most worrying issues for science due to the difficulties related to clinical treatment and the rapid spread of diseases. Efflux pumps are classified into six groups of carrier proteins that are part of the different types of mechanism...
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| Veröffentlicht in: | Life sciences (1973) 2022-04, Vol.295, p.120391-120391, Article 120391 |
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| container_title | Life sciences (1973) |
| container_volume | 295 |
| creator | Garcia, Ítalo Rodrigues de Oliveira Garcia, Francisca Adilfa Pereira, Pedro Silvino Coutinho, Henrique Douglas Melo Siyadatpanah, Abolghasem Norouzi, Roghayeh Wilairatana, Polrat de Lourdes Pereira, Maria Nissapatorn, Veeranoot Tintino, Saulo Relison Rodrigues, Fabiola Fernandes Galvão |
| description | The microorganism resistance to antibiotics has become one of the most worrying issues for science due to the difficulties related to clinical treatment and the rapid spread of diseases. Efflux pumps are classified into six groups of carrier proteins that are part of the different types of mechanisms that contribute to resistance in microorganisms, allowing their survival. The present study aimed to carry out a bibliographic review on the superfamilies of carriers in order to understand their compositions, expressions, substrates, and role in intrinsic resistance. At first, a search for manuscripts was carried out in the databases Medline, Pubmed, ScienceDirect, and Scielo, using as descriptors: efflux pump, expression, pump inhibitors and efflux superfamily. For article selection, two criteria were taken into account: for inclusion, those published between 2000 and 2020, including textbooks, and for exclusion, duplicates and academic collections. In this research, 139,615 published articles were obtained, with 312 selected articles and 7 book chapters that best met the aim. From the comprehensive analysis, it was possible to consider that the chromosomes and genetic elements can contain genes encoding efflux pumps and are responsible for multidrug resistance. Even though this is a well-explored topic in the scientific community, understanding the behavior of antibiotics as substrates that increase the expression of pump-encoding genes has challenged medicine. This review study succinctly summarizes the most relevant features of these systems, as well as their contribution to multidrug resistance.
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| doi_str_mv | 10.1016/j.lfs.2022.120391 |
| format | Article |
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[Display omitted]</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Bacterial Proteins - genetics</subject><subject>Biological Transport</subject><subject>Carrier Proteins - metabolism</subject><subject>Carrier Proteins - physiology</subject><subject>Drug Resistance, Microbial - genetics</subject><subject>Drug Resistance, Microbial - physiology</subject><subject>Drug Resistance, Multiple, Bacterial - drug effects</subject><subject>Efflux</subject><subject>Humans</subject><subject>Inhibitors</subject><subject>Membrane Transport Proteins - metabolism</subject><subject>Microbial Sensitivity Tests</subject><subject>Superfamilies</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwA1iQR5aW87lOE5hQxZdUxFImBstJzqqrpAl2UsG_x1ULI8uddHreV7qHsUsBEwEiuVlPKhsmCIgTgSAzccSGIp1lY0ikOGZDAJyOJYIasLMQ1gCg1EyesoFUYpoJkQzZx6srfJM7U3FPwYXObAq65csVcd9UxBvLydqq_-JtX7c89C15a2pXOQrcbErercj5XbalonNbikgeOm86CufsxJoq0MVhj9j748Ny_jxevD29zO8X40Iq2cU5AysKKVUOqNBgkktJRuQpKJurLBMmwxJULlHaRILBtDQpTA2Qmk3jecSu972tbz57Cp2uXSioqsyGmj5oTDDFLEWUERV7ND4dgierW-9q47-1AL1zqtc6OtU7p3rvNGauDvV9XlP5l_iVGIG7PUDxya0jr0PhKHosnY9SdNm4f-p_AGM2hw8</recordid><startdate>20220415</startdate><enddate>20220415</enddate><creator>Garcia, Ítalo Rodrigues</creator><creator>de Oliveira Garcia, Francisca Adilfa</creator><creator>Pereira, Pedro Silvino</creator><creator>Coutinho, Henrique Douglas Melo</creator><creator>Siyadatpanah, Abolghasem</creator><creator>Norouzi, Roghayeh</creator><creator>Wilairatana, Polrat</creator><creator>de Lourdes Pereira, Maria</creator><creator>Nissapatorn, Veeranoot</creator><creator>Tintino, Saulo Relison</creator><creator>Rodrigues, Fabiola Fernandes Galvão</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20220415</creationdate><title>Microbial resistance: The role of efflux pump superfamilies and their respective substrates</title><author>Garcia, Ítalo Rodrigues ; 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From the comprehensive analysis, it was possible to consider that the chromosomes and genetic elements can contain genes encoding efflux pumps and are responsible for multidrug resistance. Even though this is a well-explored topic in the scientific community, understanding the behavior of antibiotics as substrates that increase the expression of pump-encoding genes has challenged medicine. This review study succinctly summarizes the most relevant features of these systems, as well as their contribution to multidrug resistance.
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| ispartof | Life sciences (1973), 2022-04, Vol.295, p.120391-120391, Article 120391 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Anti-Bacterial Agents - pharmacology Antibiotics Bacterial Proteins - genetics Biological Transport Carrier Proteins - metabolism Carrier Proteins - physiology Drug Resistance, Microbial - genetics Drug Resistance, Microbial - physiology Drug Resistance, Multiple, Bacterial - drug effects Efflux Humans Inhibitors Membrane Transport Proteins - metabolism Microbial Sensitivity Tests Superfamilies |
| title | Microbial resistance: The role of efflux pump superfamilies and their respective substrates |
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