Optimizing the bio-degradability and biocompatibility of a biogenic collagen membrane through cross-linking and zinc-doped hydroxyapatite

Biogenic collagen membranes have been widely used as soft tissue barriers in guided bone regeneration (GBR) and guided tissue regeneration (GTR). Nevertheless, their clinical performance remains unsatisfactory because of their low mechanical strength and fast degradation rate in vivo. Although cross...

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Veröffentlicht in:	Acta biomaterialia 2022-04, Vol.143, p.159-172
Hauptverfasser:	Wu, You, Chen, Shoucheng, Luo, Pu, Deng, Shudan, Shan, Zhengjie, Fang, Jinghan, Liu, Xingchen, Xie, Jiaxin, Liu, Runheng, Wu, Shiyu, Wu, Xiayi, Chen, Zetao, Yeung, Kelvin W.K., Liu, Quan, Chen, Zhuofan
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbable Implants Alendronic acid Animals Bio-degradation Biocompatibility Biodegradability Biodegradation Biogenic collagen membrane Biological properties Bisphosphonates Bone growth Bone Regeneration Chemical agents Collagen Collagen - chemistry Collagen - pharmacology Cross-linking Crosslinking Cytotoxicity Degradability Degradation Durapatite - pharmacology Hydroxyapatite Incorporation Integration Mechanical properties Membranes Membranes, Artificial Physiochemistry Rats Regeneration Regeneration (physiology) Soft tissues Tissue engineering Tissue integration Tissues Toxicity Trace elements Trace elements (nutrients) Zinc Zinc - pharmacology Zinc doped nano-hydroxyapatite
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