Protein and peptide engineering for chemical exchange saturation transfer imaging in the age of synthetic biology

At the beginning of the millennium, the first chemical exchange saturation transfer (CEST) contrast agents were bio‐organic molecules. However, later, metal‐based CEST agents (paraCEST agents) took center stage. This did not last too long as paraCEST agents showed limited translational potential. By...

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Veröffentlicht in:	NMR in biomedicine 2023-06, Vol.36 (6), p.e4712-n/a
Hauptverfasser:	Gilad, Assaf A., Bar‐Shir, Amnon, Bricco, Alexander R., Mohanta, Zinia, McMahon, Michael T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological products Biology Biosensors chemical exchange saturation transfer (CEST) Contrast agents Contrast media Contrast Media - chemistry Enhancers Genetic code Image Interpretation, Computer-Assisted - methods magnetic resonance imaging (MRI) Magnetic Resonance Imaging - methods Organic chemistry Peptides Polypeptides Protein engineering Proteins proton exchange reporter genes and molecular imaging Substrates Synthetic Biology
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