CTLA‐4 polymorphism contributes to the genetic susceptibility of epithelial ovarian cancer
Aim Cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4), an inhibitory molecule on T‐cells, plays a key role in tumorigenesis and progression. In the present study, we investigated the effects of three polymorphisms in the CTLA‐4 gene on the risk of epithelial ovarian cancer and the clinical outcomes of patie...
Gespeichert in:
| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2022-05, Vol.48 (5), p.1240-1247 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1247 |
|---|---|
| container_issue | 5 |
| container_start_page | 1240 |
| container_title | The journal of obstetrics and gynaecology research |
| container_volume | 48 |
| creator | Chen, Juan Kang, Shan Wu, Jianlei Zhao, Jian Si, Wengang Sun, Haiyan Li, Yan |
| description | Aim
Cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4), an inhibitory molecule on T‐cells, plays a key role in tumorigenesis and progression. In the present study, we investigated the effects of three polymorphisms in the CTLA‐4 gene on the risk of epithelial ovarian cancer and the clinical outcomes of patients.
Methods
A case–control study was performed in 527 epithelial ovarian cancer patients and 532 controls. Genotypes of three polymorphisms were determined by polymerase chain reaction/ligase detection reaction. A survival analysis was performed in 346 patients who were followed up for more than 3 years and 208 patients who were followed up for more than 5 years.
Results
There were significant differences in the genotype and allele distribution frequencies of the rs5742909 C/T polymorphism in CTLA‐4 between patients and controls (p = 0.009 and p = 0.04, respectively). Compared with the CC genotype, the CT + TT genotype may significantly decrease the risk of developing epithelial ovarian cancer (OR = 0.69, 95% CI = 0.52–0.91). However, no significant association between the rs231775 G/A and rs3087243 G/A polymorphisms and epithelial ovarian cancer risk was observed. The survival analysis showed that three polymorphisms may not be related to the clinical outcomes of patients.
Conclusion
Our results suggested that the rs5742909 C/T polymorphism of CTLA‐4 may decrease the genetic susceptibility to epithelial ovarian cancer among northern Chinese women. |
| doi_str_mv | 10.1111/jog.15186 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2628296495</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2628296495</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3776-8160f3c131ed70151ae86f2c3399d684fb0e1502234b08b8a074b63e0beebf353</originalsourceid><addsrcrecordid>eNp10L1OwzAUBWALgfgfeAFkiQWGUDt2HGdEFRRQJZayIUW2e1NcJXGwE1A3HoFn5EkwFBiQ8GIPn4_OvQgdUXJO4xkt3eKcZlSKDbRLOc8TkmdiM74Zp4kkudhBeyEsCaF5QeU22mEZzQjh6S56GM-mF--vbxx3rl41znePNjTYuLb3Vg89BNw73D8CXkALvTU4DMFA11tta9uvsKswdDaC2qoau2flrWqxUa0Bf4C2KlUHOPy-99H91eVsfJ1M7yY344tpYliei0RSQSpmKKMwz0kcRIEUVWoYK4q5kLzSBGLfNGVcE6mlIjnXggHRALpiGdtHp-vczrunAUJfNjaWrGvVghtCmYpUpoXgxSc9-UOXbvBtbBdVlhUZLSSJ6mytjHcheKjKzttG-VVJSfm58vhrUX6tPNrj78RBNzD_lT87jmC0Bi-2htX_SeXt3WQd-QGOuIr9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2655951980</pqid></control><display><type>article</type><title>CTLA‐4 polymorphism contributes to the genetic susceptibility of epithelial ovarian cancer</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Chen, Juan ; Kang, Shan ; Wu, Jianlei ; Zhao, Jian ; Si, Wengang ; Sun, Haiyan ; Li, Yan</creator><creatorcontrib>Chen, Juan ; Kang, Shan ; Wu, Jianlei ; Zhao, Jian ; Si, Wengang ; Sun, Haiyan ; Li, Yan</creatorcontrib><description>Aim
Cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4), an inhibitory molecule on T‐cells, plays a key role in tumorigenesis and progression. In the present study, we investigated the effects of three polymorphisms in the CTLA‐4 gene on the risk of epithelial ovarian cancer and the clinical outcomes of patients.
Methods
A case–control study was performed in 527 epithelial ovarian cancer patients and 532 controls. Genotypes of three polymorphisms were determined by polymerase chain reaction/ligase detection reaction. A survival analysis was performed in 346 patients who were followed up for more than 3 years and 208 patients who were followed up for more than 5 years.
Results
There were significant differences in the genotype and allele distribution frequencies of the rs5742909 C/T polymorphism in CTLA‐4 between patients and controls (p = 0.009 and p = 0.04, respectively). Compared with the CC genotype, the CT + TT genotype may significantly decrease the risk of developing epithelial ovarian cancer (OR = 0.69, 95% CI = 0.52–0.91). However, no significant association between the rs231775 G/A and rs3087243 G/A polymorphisms and epithelial ovarian cancer risk was observed. The survival analysis showed that three polymorphisms may not be related to the clinical outcomes of patients.
Conclusion
Our results suggested that the rs5742909 C/T polymorphism of CTLA‐4 may decrease the genetic susceptibility to epithelial ovarian cancer among northern Chinese women.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.15186</identifier><identifier>PMID: 35150042</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Carcinoma, Ovarian Epithelial - genetics ; Case-Control Studies ; clinical outcome ; Clinical outcomes ; CTLA-4 Antigen - genetics ; CTLA‐4 ; Cytotoxicity ; epithelial ovarian cancer ; Female ; Gene frequency ; Gene polymorphism ; Genetic Predisposition to Disease ; genetic susceptibility ; Genotype ; Genotype & phenotype ; Humans ; Lymphocytes ; Ovarian cancer ; Ovarian Neoplasms - genetics ; Patients ; Polymerase chain reaction ; Polymorphism ; Polymorphism, Single Nucleotide ; Survival analysis ; Tumorigenesis</subject><ispartof>The journal of obstetrics and gynaecology research, 2022-05, Vol.48 (5), p.1240-1247</ispartof><rights>2022 Japan Society of Obstetrics and Gynecology.</rights><rights>2022 Japan Society of Obstetrics and Gynecology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3776-8160f3c131ed70151ae86f2c3399d684fb0e1502234b08b8a074b63e0beebf353</citedby><cites>FETCH-LOGICAL-c3776-8160f3c131ed70151ae86f2c3399d684fb0e1502234b08b8a074b63e0beebf353</cites><orcidid>0000-0002-9821-4351</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.15186$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.15186$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35150042$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Juan</creatorcontrib><creatorcontrib>Kang, Shan</creatorcontrib><creatorcontrib>Wu, Jianlei</creatorcontrib><creatorcontrib>Zhao, Jian</creatorcontrib><creatorcontrib>Si, Wengang</creatorcontrib><creatorcontrib>Sun, Haiyan</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><title>CTLA‐4 polymorphism contributes to the genetic susceptibility of epithelial ovarian cancer</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim
Cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4), an inhibitory molecule on T‐cells, plays a key role in tumorigenesis and progression. In the present study, we investigated the effects of three polymorphisms in the CTLA‐4 gene on the risk of epithelial ovarian cancer and the clinical outcomes of patients.
Methods
A case–control study was performed in 527 epithelial ovarian cancer patients and 532 controls. Genotypes of three polymorphisms were determined by polymerase chain reaction/ligase detection reaction. A survival analysis was performed in 346 patients who were followed up for more than 3 years and 208 patients who were followed up for more than 5 years.
Results
There were significant differences in the genotype and allele distribution frequencies of the rs5742909 C/T polymorphism in CTLA‐4 between patients and controls (p = 0.009 and p = 0.04, respectively). Compared with the CC genotype, the CT + TT genotype may significantly decrease the risk of developing epithelial ovarian cancer (OR = 0.69, 95% CI = 0.52–0.91). However, no significant association between the rs231775 G/A and rs3087243 G/A polymorphisms and epithelial ovarian cancer risk was observed. The survival analysis showed that three polymorphisms may not be related to the clinical outcomes of patients.
Conclusion
Our results suggested that the rs5742909 C/T polymorphism of CTLA‐4 may decrease the genetic susceptibility to epithelial ovarian cancer among northern Chinese women.</description><subject>Carcinoma, Ovarian Epithelial - genetics</subject><subject>Case-Control Studies</subject><subject>clinical outcome</subject><subject>Clinical outcomes</subject><subject>CTLA-4 Antigen - genetics</subject><subject>CTLA‐4</subject><subject>Cytotoxicity</subject><subject>epithelial ovarian cancer</subject><subject>Female</subject><subject>Gene frequency</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>genetic susceptibility</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Humans</subject><subject>Lymphocytes</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Patients</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Survival analysis</subject><subject>Tumorigenesis</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10L1OwzAUBWALgfgfeAFkiQWGUDt2HGdEFRRQJZayIUW2e1NcJXGwE1A3HoFn5EkwFBiQ8GIPn4_OvQgdUXJO4xkt3eKcZlSKDbRLOc8TkmdiM74Zp4kkudhBeyEsCaF5QeU22mEZzQjh6S56GM-mF--vbxx3rl41znePNjTYuLb3Vg89BNw73D8CXkALvTU4DMFA11tta9uvsKswdDaC2qoau2flrWqxUa0Bf4C2KlUHOPy-99H91eVsfJ1M7yY344tpYliei0RSQSpmKKMwz0kcRIEUVWoYK4q5kLzSBGLfNGVcE6mlIjnXggHRALpiGdtHp-vczrunAUJfNjaWrGvVghtCmYpUpoXgxSc9-UOXbvBtbBdVlhUZLSSJ6mytjHcheKjKzttG-VVJSfm58vhrUX6tPNrj78RBNzD_lT87jmC0Bi-2htX_SeXt3WQd-QGOuIr9</recordid><startdate>202205</startdate><enddate>202205</enddate><creator>Chen, Juan</creator><creator>Kang, Shan</creator><creator>Wu, Jianlei</creator><creator>Zhao, Jian</creator><creator>Si, Wengang</creator><creator>Sun, Haiyan</creator><creator>Li, Yan</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9821-4351</orcidid></search><sort><creationdate>202205</creationdate><title>CTLA‐4 polymorphism contributes to the genetic susceptibility of epithelial ovarian cancer</title><author>Chen, Juan ; Kang, Shan ; Wu, Jianlei ; Zhao, Jian ; Si, Wengang ; Sun, Haiyan ; Li, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3776-8160f3c131ed70151ae86f2c3399d684fb0e1502234b08b8a074b63e0beebf353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Carcinoma, Ovarian Epithelial - genetics</topic><topic>Case-Control Studies</topic><topic>clinical outcome</topic><topic>Clinical outcomes</topic><topic>CTLA-4 Antigen - genetics</topic><topic>CTLA‐4</topic><topic>Cytotoxicity</topic><topic>epithelial ovarian cancer</topic><topic>Female</topic><topic>Gene frequency</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>genetic susceptibility</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Humans</topic><topic>Lymphocytes</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Patients</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Survival analysis</topic><topic>Tumorigenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Juan</creatorcontrib><creatorcontrib>Kang, Shan</creatorcontrib><creatorcontrib>Wu, Jianlei</creatorcontrib><creatorcontrib>Zhao, Jian</creatorcontrib><creatorcontrib>Si, Wengang</creatorcontrib><creatorcontrib>Sun, Haiyan</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Juan</au><au>Kang, Shan</au><au>Wu, Jianlei</au><au>Zhao, Jian</au><au>Si, Wengang</au><au>Sun, Haiyan</au><au>Li, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CTLA‐4 polymorphism contributes to the genetic susceptibility of epithelial ovarian cancer</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2022-05</date><risdate>2022</risdate><volume>48</volume><issue>5</issue><spage>1240</spage><epage>1247</epage><pages>1240-1247</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim
Cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4), an inhibitory molecule on T‐cells, plays a key role in tumorigenesis and progression. In the present study, we investigated the effects of three polymorphisms in the CTLA‐4 gene on the risk of epithelial ovarian cancer and the clinical outcomes of patients.
Methods
A case–control study was performed in 527 epithelial ovarian cancer patients and 532 controls. Genotypes of three polymorphisms were determined by polymerase chain reaction/ligase detection reaction. A survival analysis was performed in 346 patients who were followed up for more than 3 years and 208 patients who were followed up for more than 5 years.
Results
There were significant differences in the genotype and allele distribution frequencies of the rs5742909 C/T polymorphism in CTLA‐4 between patients and controls (p = 0.009 and p = 0.04, respectively). Compared with the CC genotype, the CT + TT genotype may significantly decrease the risk of developing epithelial ovarian cancer (OR = 0.69, 95% CI = 0.52–0.91). However, no significant association between the rs231775 G/A and rs3087243 G/A polymorphisms and epithelial ovarian cancer risk was observed. The survival analysis showed that three polymorphisms may not be related to the clinical outcomes of patients.
Conclusion
Our results suggested that the rs5742909 C/T polymorphism of CTLA‐4 may decrease the genetic susceptibility to epithelial ovarian cancer among northern Chinese women.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>35150042</pmid><doi>10.1111/jog.15186</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9821-4351</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1341-8076 |
| ispartof | The journal of obstetrics and gynaecology research, 2022-05, Vol.48 (5), p.1240-1247 |
| issn | 1341-8076 1447-0756 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2628296495 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Carcinoma, Ovarian Epithelial - genetics Case-Control Studies clinical outcome Clinical outcomes CTLA-4 Antigen - genetics CTLA‐4 Cytotoxicity epithelial ovarian cancer Female Gene frequency Gene polymorphism Genetic Predisposition to Disease genetic susceptibility Genotype Genotype & phenotype Humans Lymphocytes Ovarian cancer Ovarian Neoplasms - genetics Patients Polymerase chain reaction Polymorphism Polymorphism, Single Nucleotide Survival analysis Tumorigenesis |
| title | CTLA‐4 polymorphism contributes to the genetic susceptibility of epithelial ovarian cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T03%3A11%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CTLA%E2%80%904%20polymorphism%20contributes%20to%20the%20genetic%20susceptibility%20of%20epithelial%20ovarian%20cancer&rft.jtitle=The%20journal%20of%20obstetrics%20and%20gynaecology%20research&rft.au=Chen,%20Juan&rft.date=2022-05&rft.volume=48&rft.issue=5&rft.spage=1240&rft.epage=1247&rft.pages=1240-1247&rft.issn=1341-8076&rft.eissn=1447-0756&rft_id=info:doi/10.1111/jog.15186&rft_dat=%3Cproquest_cross%3E2628296495%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2655951980&rft_id=info:pmid/35150042&rfr_iscdi=true |