Replacing arginine 99 with leucine to study the kinetics of interconnected allosteric interactions between FFAR4 and naturally occurring fatty acids

[Display omitted] •First study effect of replacing Arg99 with Leu on hFFAR4 recognition FFAs.•Mathematical models were used to compare kinetic parameters of different FFAs.•The Ka of most fatty acids increased after replacing arginine 99 with leucine.•Arg99 plays an important role in the recognition...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Food chemistry 2022-07, Vol.382, p.132323-132323, Article 132323
Hauptverfasser:	Niu, Bo, Lu, Dingqiang, Zheng, Ziqing, Yuan, Shuai, Pang, Guangchang
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine Electrochemical receptor sensor Fatty Acids Gold Human fatty acid receptor 4 Interconnected allosteric interaction Kinetics Leucine Metal Nanoparticles Naturally occurring fatty acids Receptors, G-Protein-Coupled - genetics Receptor–ligand interaction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!