Bone remodeling following mandibular reconstruction using fibula free flap
To investigate bone remodelling responses to mandibulectomy, a joint external and internal remodelling algorithm is developed here by incorporating patient-specific longitudinal data. The primary aim of this study is to simulate bone remodelling activity in the conjunction region with a fibula free...
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| Veröffentlicht in: | Journal of biomechanics 2022-03, Vol.133, p.110968-110968, Article 110968 |
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| creator | Zheng, Keke Yoda, Nobuhiro Chen, Junning Liao, Zhipeng Zhong, Jingxiao Wu, Chi Wan, Boyang Koyama, Shigeto Sasaki, Keiichi Peck, Christopher Swain, Michael Li, Qing |
| description | To investigate bone remodelling responses to mandibulectomy, a joint external and internal remodelling algorithm is developed here by incorporating patient-specific longitudinal data. The primary aim of this study is to simulate bone remodelling activity in the conjunction region with a fibula free flap (FFF) reconstruction by correlating with a 28-month clinical follow-up. The secondary goal of this study is to compare the long-term outcomes of different designs of fixation plate with specific screw positioning. The results indicated that the overall bone density decreased over time, except for the Docking Site (namely DS1, a region of interest in mandibular symphysis with the conjunction of the bone union), in which the decrease of bone density ceased later and was followed by bone apposition. A negligible influence on bone remodeling outcome was found for different screw positioning. This study is believed to be the first of its kind for computationally simulating the bone turn-over process after FFF maxillofacial reconstruction by correlating with patient-specific follow-up. |
| doi_str_mv | 10.1016/j.jbiomech.2022.110968 |
| format | Article |
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The primary aim of this study is to simulate bone remodelling activity in the conjunction region with a fibula free flap (FFF) reconstruction by correlating with a 28-month clinical follow-up. The secondary goal of this study is to compare the long-term outcomes of different designs of fixation plate with specific screw positioning. The results indicated that the overall bone density decreased over time, except for the Docking Site (namely DS1, a region of interest in mandibular symphysis with the conjunction of the bone union), in which the decrease of bone density ceased later and was followed by bone apposition. A negligible influence on bone remodeling outcome was found for different screw positioning. This study is believed to be the first of its kind for computationally simulating the bone turn-over process after FFF maxillofacial reconstruction by correlating with patient-specific follow-up.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2022.110968</identifier><identifier>PMID: 35139441</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Algorithms ; Apposition ; Biomechanics ; Bone density ; Bone Remodeling ; Bone remodelling ; Bone Transplantation ; Fibula ; Fibula - surgery ; Free Tissue Flaps - surgery ; Humans ; Mandible ; Mandible - physiology ; Mandible - surgery ; Mandibular Reconstruction - methods ; Maxillofacial ; Maxillofacial reconstruction ; Medical imaging ; Morphology ; Patients ; Placement design of fixation plate ; Reconstruction ; Reconstructive Surgical Procedures - methods ; Retrospective Studies ; Surgery ; Time-dependent remodelling algorithm. Clinical follow-up</subject><ispartof>Journal of biomechanics, 2022-03, Vol.133, p.110968-110968, Article 110968</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><rights>2022. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-34e0dd2131a93583f5338aea91ec570307619f66793858dd447759e678adc3ab3</citedby><cites>FETCH-LOGICAL-c510t-34e0dd2131a93583f5338aea91ec570307619f66793858dd447759e678adc3ab3</cites><orcidid>0000-0001-7121-0994 ; 0000-0002-7930-2145 ; 0000-0001-6438-4902 ; 0000-0002-6380-0641 ; 0000-0003-0337-1395</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2633247197?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35139441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Keke</creatorcontrib><creatorcontrib>Yoda, Nobuhiro</creatorcontrib><creatorcontrib>Chen, Junning</creatorcontrib><creatorcontrib>Liao, Zhipeng</creatorcontrib><creatorcontrib>Zhong, Jingxiao</creatorcontrib><creatorcontrib>Wu, Chi</creatorcontrib><creatorcontrib>Wan, Boyang</creatorcontrib><creatorcontrib>Koyama, Shigeto</creatorcontrib><creatorcontrib>Sasaki, Keiichi</creatorcontrib><creatorcontrib>Peck, Christopher</creatorcontrib><creatorcontrib>Swain, Michael</creatorcontrib><creatorcontrib>Li, Qing</creatorcontrib><title>Bone remodeling following mandibular reconstruction using fibula free flap</title><title>Journal of biomechanics</title><addtitle>J Biomech</addtitle><description>To investigate bone remodelling responses to mandibulectomy, a joint external and internal remodelling algorithm is developed here by incorporating patient-specific longitudinal data. The primary aim of this study is to simulate bone remodelling activity in the conjunction region with a fibula free flap (FFF) reconstruction by correlating with a 28-month clinical follow-up. The secondary goal of this study is to compare the long-term outcomes of different designs of fixation plate with specific screw positioning. The results indicated that the overall bone density decreased over time, except for the Docking Site (namely DS1, a region of interest in mandibular symphysis with the conjunction of the bone union), in which the decrease of bone density ceased later and was followed by bone apposition. A negligible influence on bone remodeling outcome was found for different screw positioning. This study is believed to be the first of its kind for computationally simulating the bone turn-over process after FFF maxillofacial reconstruction by correlating with patient-specific follow-up.</description><subject>Algorithms</subject><subject>Apposition</subject><subject>Biomechanics</subject><subject>Bone density</subject><subject>Bone Remodeling</subject><subject>Bone remodelling</subject><subject>Bone Transplantation</subject><subject>Fibula</subject><subject>Fibula - surgery</subject><subject>Free Tissue Flaps - surgery</subject><subject>Humans</subject><subject>Mandible</subject><subject>Mandible - physiology</subject><subject>Mandible - surgery</subject><subject>Mandibular Reconstruction - methods</subject><subject>Maxillofacial</subject><subject>Maxillofacial reconstruction</subject><subject>Medical imaging</subject><subject>Morphology</subject><subject>Patients</subject><subject>Placement design of fixation plate</subject><subject>Reconstruction</subject><subject>Reconstructive Surgical Procedures - methods</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Time-dependent remodelling algorithm. 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The primary aim of this study is to simulate bone remodelling activity in the conjunction region with a fibula free flap (FFF) reconstruction by correlating with a 28-month clinical follow-up. The secondary goal of this study is to compare the long-term outcomes of different designs of fixation plate with specific screw positioning. The results indicated that the overall bone density decreased over time, except for the Docking Site (namely DS1, a region of interest in mandibular symphysis with the conjunction of the bone union), in which the decrease of bone density ceased later and was followed by bone apposition. A negligible influence on bone remodeling outcome was found for different screw positioning. 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| subjects | Algorithms Apposition Biomechanics Bone density Bone Remodeling Bone remodelling Bone Transplantation Fibula Fibula - surgery Free Tissue Flaps - surgery Humans Mandible Mandible - physiology Mandible - surgery Mandibular Reconstruction - methods Maxillofacial Maxillofacial reconstruction Medical imaging Morphology Patients Placement design of fixation plate Reconstruction Reconstructive Surgical Procedures - methods Retrospective Studies Surgery Time-dependent remodelling algorithm. Clinical follow-up |
| title | Bone remodeling following mandibular reconstruction using fibula free flap |
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