Early aggregation mechanism of Aβ16−22 revealed by Markov state models

Aβ16–22 is believed to have critical role in early aggregation of full length amyloids that are associated with the Alzheimer's disease and can aggregate to form amyloid fibrils. However, the early aggregation mechanism is still unsolved. Here, multiple long-term molecular dynamics simulations...

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Veröffentlicht in:	International journal of biological macromolecules 2022-04, Vol.204, p.606-616
Hauptverfasser:	Rahman, Mueed Ur, Song, Kaiyuan, Da, Lin-Tai, Chen, Hai-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation mechanism Amyloid Markov state model
Online-Zugang:	Volltext
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