Synergistic apoptotic effect of Mcl-1 inhibition and doxorubicin on B-cell precursor acute lymphoblastic leukemia cells

Background Myeloid cell leukemia-1 (MCL-1) is a component of the Bcl-2 anti-apoptotic family that plays a key role in cell proliferation and differentiation. Despite tremendous improvements toward identification of the role of MCL-1 in leukemia progression, the functional significance and molecular...

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Veröffentlicht in:	Molecular biology reports 2022-03, Vol.49 (3), p.2025-2036
Hauptverfasser:	Ebrahimi, Elham, Shabestari, Rima Manafi, Bashash, Davood, Safa, Majid
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Animal Anatomy Animal Biochemistry Apoptosis Bcl-2 protein Biomedical and Life Sciences Caspase-3 Cell activation Cell differentiation Cell growth Cell Line, Tumor Cell proliferation Doxorubicin Doxorubicin - pharmacology Gene expression Histology Humans Kinases Leukemia Leukocytes (mononuclear) Life Sciences Lymphatic leukemia Lymphocytes B Mcl-1 protein Morphology mRNA Myeloid Cell Leukemia Sequence 1 Protein - genetics Myeloid Cell Leukemia Sequence 1 Protein - metabolism Original Article Precursor Cell Lymphoblastic Leukemia-Lymphoma Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism
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