Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2

The SARS-CoV-2 virus has infected more than 261 million people and has led to more than 5 million deaths in the past year and a half 1 ( https://www.who.org/ ). Individuals with SARS-CoV-2 infection typically develop mild-to-severe flu-like symptoms, whereas infection of a subset of individuals lead...

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Veröffentlicht in:	Nature (London) 2022-04, Vol.604 (7904), p.134-140
Hauptverfasser:	Schultz, David C., Johnson, Robert M., Ayyanathan, Kasirajan, Miller, Jesse, Whig, Kanupriya, Kamalia, Brinda, Dittmar, Mark, Weston, Stuart, Hammond, Holly L., Dillen, Carly, Ardanuy, Jeremy, Taylor, Louis, Lee, Jae Seung, Li, Minghua, Lee, Emily, Shoffler, Clarissa, Petucci, Christopher, Constant, Samuel, Ferrer, Marc, Thaiss, Christoph A., Frieman, Matthew B., Cherry, Sara
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/1435 631/326/596 631/326/596/4130 Adenosine Adenosine Monophosphate - analogs & derivatives Alanine - analogs & derivatives Antiviral activity Antiviral agents Antiviral Agents - pharmacology Biosynthesis Cell Line Competition Coronaviruses COVID-19 COVID-19 - virology COVID-19 Drug Treatment Cytidine - analogs & derivatives Cytotoxicity Drug development Drug Evaluation, Preclinical Drugs Humanities and Social Sciences Humans Hydroxylamines Infections Inhibitors Ligands multidisciplinary Mutagenesis Nucleoside analogs Nucleoside triphosphates Nucleosides Nucleosides - analogs & derivatives Nucleosides - pharmacology Pyrimidines - pharmacology RNA polymerase RNA viruses SARS-CoV-2 - drug effects Science Science (multidisciplinary) Selectivity Severe acute respiratory syndrome coronavirus 2 Synergism Toxicity Vaccines Viral diseases Viral infections Viruses
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