Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway

Zaire ebolavirus (EBOV) causes a severe hemorrhagic fever in humans and non-human primates with high morbidity and mortality. EBOV infection is dependent on its structural glycoprotein (GP), but high levels of GP expression also trigger cell rounding, detachment, and downregulation of many surface m...

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Veröffentlicht in:	Autophagy 2022-10, Vol.18 (10), p.2350-2367
Hauptverfasser:	Wang, Bin, Zhang, Jing, Liu, Xin, Chai, Qingqing, Lu, Xiaoran, Yao, Xiaoyu, Yang, Zhichang, Sun, Liangliang, Johnson, Silas F., Schwartz, Richard C, Zheng, Yong-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism alpha-Mannosidase - genetics alpha-Mannosidase - metabolism alpha-Mannosidase - pharmacology Animals Autophagy Calnexin - metabolism Calreticulin - genetics Calreticulin - metabolism Calreticulin - pharmacology CRISPR-Associated Protein 9 - genetics CRISPR-Associated Protein 9 - metabolism CRISPR-Associated Protein 9 - pharmacology Cycloheximide Cysteine - metabolism Disulfides ebola Ebolavirus Endoplasmic Reticulum - metabolism ER-phagy ERAD ERp57 EVD filoviruses glycoproteins Glycoproteins - metabolism Heat-Shock Proteins - metabolism Hemagglutinins - metabolism Hemagglutinins - pharmacology Histone Deacetylase 6 - genetics Intercellular Signaling Peptides and Proteins Lysosomal Membrane Proteins - metabolism lysosomes Lysosomes - metabolism Microtubule-Associated Proteins - metabolism Mucins - genetics Mucins - metabolism Mucins - pharmacology Prokaryotic Initiation Factor-2 - genetics Prokaryotic Initiation Factor-2 - metabolism Prokaryotic Initiation Factor-2 - pharmacology Protein Disulfide-Isomerases - genetics Protein Disulfide-Isomerases - metabolism Research Paper reticulophagy RNA, Double-Stranded - metabolism RNA, Double-Stranded - pharmacology Sequestosome-1 Protein - metabolism Thapsigargin - metabolism Thapsigargin - pharmacology Thioredoxins - genetics Thioredoxins - metabolism Thioredoxins - pharmacology Ubiquitins - metabolism X-Box Binding Protein 1 - metabolism
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