Alcohol dehydrogenase expression patterns in normal prostate, benign prostatic hyperplasia, and prostatic adenocarcinoma in African American and Caucasian men

Background In situ metabolism of ethanol by alcohol dehydrogenases (ADHs) contributes to oxidative damage of cells and DNA and has been linked to carcinogenesis in numerous epithelial tissues. The goal of this study was to determine expression patterns of ADH1 and ADH7 isozymes in normal, hyperplast...

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Veröffentlicht in:	The Prostate 2022-05, Vol.82 (6), p.666-675
Hauptverfasser:	Stamis, Sarah A., Heath, Elisabeth I., Lucas, Steven, Boerner, Julie, Slusher, Leslie B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - pathology ADH1B ADH7 African Americans African Americans - genetics Alcohol dehydrogenase Alcohol Dehydrogenase - genetics Alcohol Dehydrogenase - metabolism Biopsy BPH Carcinogenesis DNA damage Epithelium Ethanol Genital diseases Humans Hyperplasia Immunohistochemistry Isoenzymes Lasers Male Paraffin PCa Prostate Prostate - pathology Prostate cancer Prostatic Hyperplasia - pathology Prostatic Neoplasms - pathology Racial differences RNA, Messenger - metabolism tissue dysregulation Transcription White people
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