Gadopentetate meglumine activates mast cells to cause IgE-independent allergic reactions both in vitro and in vivo

•Gd-DTPA directly induced mast cells activation in vitro.•Gd-DTPA IgE-independently induced cutaneous and systemic anaphylaxis in mice.•Gd-DTPA induced several cytokines release relevant to PI3K-Akt pathway and cytokine-cytokine receptor interaction in mast cells. Gadopentetate meglumine (Gd-DTPA) i...

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Veröffentlicht in:	International immunopharmacology 2022-05, Vol.106, p.108602-108602, Article 108602
Hauptverfasser:	Liu, Xin, Zhang, Yufei, Cui, Xu, Fan, Ting, Shu, Jin, Li, Hui, Huo, Xiaojing, Lu, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic reactions Allergies Anaphylactoid reactions Body temperature Cell activation Cytokines Gadolinium Gd-DTPA Histamine IgE-independent allergy Immunoglobulin E In vivo methods and tests Inflammation Intravenous administration Magnetic resonance imaging Mast cell Mast cells mRNA Reaction mechanisms RNA-seq Tryptase
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