Tertiary lymphoid structures and their association to immune phenotypes and circulatory IL2 levels in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDA) is usually unresponsive to immunotherapeutic approaches. However, tertiary lymphoid structures (TLS) are associated with favorable patient outcomes in PDA. A better understanding of the B cell infiltrate and biological features of TLS formation is needed to fur...

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Veröffentlicht in:	Oncoimmunology 2022-12, Vol.11 (1), p.2027148
Hauptverfasser:	Ahmed, Azaz, Köhler, Sophia, Klotz, Rosa, Giese, Nathalia, Hackert, Thilo, Springfeld, Christoph, Zörnig, Inka, Jäger, Dirk, Halama, Niels
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Pancreatic Ductal CD8-Positive T-Lymphocytes Humans Interleukin-2 Interleukin-2 - blood Pancreatic ductal adenocarcinoma Pancreatic Neoplasms Phenotype Tertiary lymphoid structures Tertiary Lymphoid Structures - pathology Tumor Microenvironment
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