proBDNF/p75NTR promotes rheumatoid arthritis and inflammatory response by activating proinflammatory cytokines

P75 pan‐neurotrophin receptor (p75NTR) is an important receptor for the role of neurotrophins in survival and death of neurons during development and after nerve injury. Our previous research found that the precursor of brain‐derived neurotrophic factor (proBDNF) regulates pain as an inflammatory me...

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Veröffentlicht in:	The FASEB journal 2022-03, Vol.36 (3), p.e22180-n/a
Hauptverfasser:	Yang, Chun‐Rui, Ding, Hong‐Jun, Yu, Miao, Zhou, Fiona‐H., Han, Chen‐Yang, Liang, Rui, Zhang, Xiao‐Yang, Zhang, Xiang‐Lian, Meng, Fan‐Jie, Wang, Shuo, Li, De‐Dong, Sun, Wei‐Zong, Meng, Bin, Zhou, Xin‐Fu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Arthritis, Rheumatoid - metabolism Brain-Derived Neurotrophic Factor - metabolism Female Humans inflammation Interleukins - blood Interleukins - metabolism Leukocytes, Mononuclear - metabolism Male Mice Mice, Inbred C57BL Middle Aged Nerve Tissue Proteins - metabolism p75NTR pain proBDNF Protein Precursors - metabolism Receptors, Nerve Growth Factor - metabolism rheumatoid arthritis Synovial Membrane - metabolism T-Lymphocytes - metabolism Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - metabolism
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