Association of Preoperative Sarcopenia with Adverse Outcomes of Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Flap
Background Sarcopenia, defined as a significant loss of skeletal muscle mass and function, is suggested to be associated with an increased risk of complications after various surgical interventions. However, evidence regarding sarcopenia in microsurgical breast reconstruction has been lacking. The p...
Gespeichert in:
| Veröffentlicht in: | Annals of surgical oncology 2022-06, Vol.29 (6), p.3800-3808 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3808 |
|---|---|
| container_issue | 6 |
| container_start_page | 3800 |
| container_title | Annals of surgical oncology |
| container_volume | 29 |
| creator | Kim, Sungjin Lee, Kyeong-Tae Jeon, Byung-Joon Pyon, Jai Kyong Mun, Goo-Hyun |
| description | Background
Sarcopenia, defined as a significant loss of skeletal muscle mass and function, is suggested to be associated with an increased risk of complications after various surgical interventions. However, evidence regarding sarcopenia in microsurgical breast reconstruction has been lacking. The present study was designed to evaluate the association between preoperative sarcopenia and adverse outcomes in deep inferior epigastric perforator (DIEP) flap-based breast reconstruction.
Methods
Patients who underwent breast reconstruction using DIEP flap between 2009 and 2018 were reviewed. Sarcopenia was defined as a skeletal muscle index |
| doi_str_mv | 10.1245/s10434-022-11362-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2626224193</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2626224193</sourcerecordid><originalsourceid>FETCH-LOGICAL-c305t-f4bb9e9d4e2b9d50b6bb03a35c7255f0a2f31d557965111f693ac7f62fa244c3</originalsourceid><addsrcrecordid>eNp9kc9u1DAQxi0Eou3CC3BAlrhwCfh_4uNSWqhUqRWUs-U448XVbhzGSVGfgZeu2y0gcUCW7BnPb74Z6SPkFWfvuFD6feFMSdUwIRrOpan3E3LIdf1SpuNPa8xM11hh9AE5KuWaMd5Kpp-TA6m56LRtD8mvdSk5JD-nPNIc6SVCngBrfgP0q8dQszF5-jPN3-l6uAEsQC-WOeQdlPuGDwi-zPQLhDyWGZfwoPStpHFDPwJM9GyMgCkjPZnSpqKYAl3jDHhLLwFjrrNq8XTrpxfkWfTbAi8f3xW5Oj25Ov7cnF98Ojtenzehbj83UfW9BTsoEL0dNOtN3zPppQ6t0DoyL6Lkg9atNZpzHo2VPrTRiOiFUkGuyNu97IT5xwJldrtUAmy3foS8FCdMPUJxKyv65h_0Oi841uUqpW3HO1OxFRF7KmAuBSG6CdPO463jzN075fZOueqUe3DK8dr0-lF66Xcw_Gn5bU0F5B4otTRuAP_O_o_sHc0HoEU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2659818619</pqid></control><display><type>article</type><title>Association of Preoperative Sarcopenia with Adverse Outcomes of Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Flap</title><source>SpringerLink Journals - AutoHoldings</source><creator>Kim, Sungjin ; Lee, Kyeong-Tae ; Jeon, Byung-Joon ; Pyon, Jai Kyong ; Mun, Goo-Hyun</creator><creatorcontrib>Kim, Sungjin ; Lee, Kyeong-Tae ; Jeon, Byung-Joon ; Pyon, Jai Kyong ; Mun, Goo-Hyun</creatorcontrib><description>Background
Sarcopenia, defined as a significant loss of skeletal muscle mass and function, is suggested to be associated with an increased risk of complications after various surgical interventions. However, evidence regarding sarcopenia in microsurgical breast reconstruction has been lacking. The present study was designed to evaluate the association between preoperative sarcopenia and adverse outcomes in deep inferior epigastric perforator (DIEP) flap-based breast reconstruction.
Methods
Patients who underwent breast reconstruction using DIEP flap between 2009 and 2018 were reviewed. Sarcopenia was defined as a skeletal muscle index < 38.5 cm
2
/m
2
, calculated by normalizing the cross-sectional area of the skeletal muscle, measured at the level of the third lumbar vertebra based on preoperative computed tomography angiography, to patient height. Postoperative complication rates were compared between patients with sarcopenia and those without it. Independent association of sarcopenia with complication profiles were evaluated. Further analyses were conducted using propensity score matching.
Results
In total, 557 patients were analyzed, of which 154 (27.6%) had preoperative sarcopenia. The sarcopenia group had a significantly lower body mass index, a lower elevated flap weight, and greater use of bipedicled flaps compared to the nonsarcopenia group. Complications developed in 128 patients (23.0%) and were more prevalent in the sarcopenia group. Preoperative sarcopenia was associated with a significantly higher rate of complications, including breast hematoma, breast wound problems, abdominal functional weakness, and reoperation in the multivariable analyses. Similar associations were observed in the propensity score matching analysis.
Conclusions
Preoperative sarcopenia appears to be associated with adverse outcomes in DIEP flap-based breast reconstruction.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-022-11362-1</identifier><identifier>PMID: 35128597</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Angiography ; Body mass index ; Breast ; Breast Oncology ; Complications ; Computed tomography ; Hematoma ; Medicine ; Medicine & Public Health ; Musculoskeletal system ; Oncology ; Postoperative ; Reconstructive surgery ; Sarcopenia ; Skeletal muscle ; Surgery ; Surgical Oncology ; Vertebrae</subject><ispartof>Annals of surgical oncology, 2022-06, Vol.29 (6), p.3800-3808</ispartof><rights>Society of Surgical Oncology 2022</rights><rights>2022. Society of Surgical Oncology.</rights><rights>Society of Surgical Oncology 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-f4bb9e9d4e2b9d50b6bb03a35c7255f0a2f31d557965111f693ac7f62fa244c3</citedby><cites>FETCH-LOGICAL-c305t-f4bb9e9d4e2b9d50b6bb03a35c7255f0a2f31d557965111f693ac7f62fa244c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-022-11362-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-022-11362-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35128597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Sungjin</creatorcontrib><creatorcontrib>Lee, Kyeong-Tae</creatorcontrib><creatorcontrib>Jeon, Byung-Joon</creatorcontrib><creatorcontrib>Pyon, Jai Kyong</creatorcontrib><creatorcontrib>Mun, Goo-Hyun</creatorcontrib><title>Association of Preoperative Sarcopenia with Adverse Outcomes of Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Flap</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Sarcopenia, defined as a significant loss of skeletal muscle mass and function, is suggested to be associated with an increased risk of complications after various surgical interventions. However, evidence regarding sarcopenia in microsurgical breast reconstruction has been lacking. The present study was designed to evaluate the association between preoperative sarcopenia and adverse outcomes in deep inferior epigastric perforator (DIEP) flap-based breast reconstruction.
Methods
Patients who underwent breast reconstruction using DIEP flap between 2009 and 2018 were reviewed. Sarcopenia was defined as a skeletal muscle index < 38.5 cm
2
/m
2
, calculated by normalizing the cross-sectional area of the skeletal muscle, measured at the level of the third lumbar vertebra based on preoperative computed tomography angiography, to patient height. Postoperative complication rates were compared between patients with sarcopenia and those without it. Independent association of sarcopenia with complication profiles were evaluated. Further analyses were conducted using propensity score matching.
Results
In total, 557 patients were analyzed, of which 154 (27.6%) had preoperative sarcopenia. The sarcopenia group had a significantly lower body mass index, a lower elevated flap weight, and greater use of bipedicled flaps compared to the nonsarcopenia group. Complications developed in 128 patients (23.0%) and were more prevalent in the sarcopenia group. Preoperative sarcopenia was associated with a significantly higher rate of complications, including breast hematoma, breast wound problems, abdominal functional weakness, and reoperation in the multivariable analyses. Similar associations were observed in the propensity score matching analysis.
Conclusions
Preoperative sarcopenia appears to be associated with adverse outcomes in DIEP flap-based breast reconstruction.</description><subject>Angiography</subject><subject>Body mass index</subject><subject>Breast</subject><subject>Breast Oncology</subject><subject>Complications</subject><subject>Computed tomography</subject><subject>Hematoma</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Musculoskeletal system</subject><subject>Oncology</subject><subject>Postoperative</subject><subject>Reconstructive surgery</subject><subject>Sarcopenia</subject><subject>Skeletal muscle</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Vertebrae</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc9u1DAQxi0Eou3CC3BAlrhwCfh_4uNSWqhUqRWUs-U448XVbhzGSVGfgZeu2y0gcUCW7BnPb74Z6SPkFWfvuFD6feFMSdUwIRrOpan3E3LIdf1SpuNPa8xM11hh9AE5KuWaMd5Kpp-TA6m56LRtD8mvdSk5JD-nPNIc6SVCngBrfgP0q8dQszF5-jPN3-l6uAEsQC-WOeQdlPuGDwi-zPQLhDyWGZfwoPStpHFDPwJM9GyMgCkjPZnSpqKYAl3jDHhLLwFjrrNq8XTrpxfkWfTbAi8f3xW5Oj25Ov7cnF98Ojtenzehbj83UfW9BTsoEL0dNOtN3zPppQ6t0DoyL6Lkg9atNZpzHo2VPrTRiOiFUkGuyNu97IT5xwJldrtUAmy3foS8FCdMPUJxKyv65h_0Oi841uUqpW3HO1OxFRF7KmAuBSG6CdPO463jzN075fZOueqUe3DK8dr0-lF66Xcw_Gn5bU0F5B4otTRuAP_O_o_sHc0HoEU</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Kim, Sungjin</creator><creator>Lee, Kyeong-Tae</creator><creator>Jeon, Byung-Joon</creator><creator>Pyon, Jai Kyong</creator><creator>Mun, Goo-Hyun</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20220601</creationdate><title>Association of Preoperative Sarcopenia with Adverse Outcomes of Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Flap</title><author>Kim, Sungjin ; Lee, Kyeong-Tae ; Jeon, Byung-Joon ; Pyon, Jai Kyong ; Mun, Goo-Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-f4bb9e9d4e2b9d50b6bb03a35c7255f0a2f31d557965111f693ac7f62fa244c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angiography</topic><topic>Body mass index</topic><topic>Breast</topic><topic>Breast Oncology</topic><topic>Complications</topic><topic>Computed tomography</topic><topic>Hematoma</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Musculoskeletal system</topic><topic>Oncology</topic><topic>Postoperative</topic><topic>Reconstructive surgery</topic><topic>Sarcopenia</topic><topic>Skeletal muscle</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Vertebrae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sungjin</creatorcontrib><creatorcontrib>Lee, Kyeong-Tae</creatorcontrib><creatorcontrib>Jeon, Byung-Joon</creatorcontrib><creatorcontrib>Pyon, Jai Kyong</creatorcontrib><creatorcontrib>Mun, Goo-Hyun</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sungjin</au><au>Lee, Kyeong-Tae</au><au>Jeon, Byung-Joon</au><au>Pyon, Jai Kyong</au><au>Mun, Goo-Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Preoperative Sarcopenia with Adverse Outcomes of Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Flap</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>29</volume><issue>6</issue><spage>3800</spage><epage>3808</epage><pages>3800-3808</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Sarcopenia, defined as a significant loss of skeletal muscle mass and function, is suggested to be associated with an increased risk of complications after various surgical interventions. However, evidence regarding sarcopenia in microsurgical breast reconstruction has been lacking. The present study was designed to evaluate the association between preoperative sarcopenia and adverse outcomes in deep inferior epigastric perforator (DIEP) flap-based breast reconstruction.
Methods
Patients who underwent breast reconstruction using DIEP flap between 2009 and 2018 were reviewed. Sarcopenia was defined as a skeletal muscle index < 38.5 cm
2
/m
2
, calculated by normalizing the cross-sectional area of the skeletal muscle, measured at the level of the third lumbar vertebra based on preoperative computed tomography angiography, to patient height. Postoperative complication rates were compared between patients with sarcopenia and those without it. Independent association of sarcopenia with complication profiles were evaluated. Further analyses were conducted using propensity score matching.
Results
In total, 557 patients were analyzed, of which 154 (27.6%) had preoperative sarcopenia. The sarcopenia group had a significantly lower body mass index, a lower elevated flap weight, and greater use of bipedicled flaps compared to the nonsarcopenia group. Complications developed in 128 patients (23.0%) and were more prevalent in the sarcopenia group. Preoperative sarcopenia was associated with a significantly higher rate of complications, including breast hematoma, breast wound problems, abdominal functional weakness, and reoperation in the multivariable analyses. Similar associations were observed in the propensity score matching analysis.
Conclusions
Preoperative sarcopenia appears to be associated with adverse outcomes in DIEP flap-based breast reconstruction.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>35128597</pmid><doi>10.1245/s10434-022-11362-1</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2022-06, Vol.29 (6), p.3800-3808 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2626224193 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Angiography Body mass index Breast Breast Oncology Complications Computed tomography Hematoma Medicine Medicine & Public Health Musculoskeletal system Oncology Postoperative Reconstructive surgery Sarcopenia Skeletal muscle Surgery Surgical Oncology Vertebrae |
| title | Association of Preoperative Sarcopenia with Adverse Outcomes of Breast Reconstruction Using Deep Inferior Epigastric Artery Perforator Flap |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T07%3A22%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20Preoperative%20Sarcopenia%20with%20Adverse%20Outcomes%20of%20Breast%20Reconstruction%20Using%20Deep%20Inferior%20Epigastric%20Artery%20Perforator%20Flap&rft.jtitle=Annals%20of%20surgical%20oncology&rft.au=Kim,%20Sungjin&rft.date=2022-06-01&rft.volume=29&rft.issue=6&rft.spage=3800&rft.epage=3808&rft.pages=3800-3808&rft.issn=1068-9265&rft.eissn=1534-4681&rft_id=info:doi/10.1245/s10434-022-11362-1&rft_dat=%3Cproquest_cross%3E2626224193%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2659818619&rft_id=info:pmid/35128597&rfr_iscdi=true |