XMU-MP-1 protects heart from ischemia/reperfusion injury in mice through modulating Mst1/AMPK pathway

Up to now, there are few therapeutic approaches available to protect heart from ischemia/reperfusion (I/R) injury. The present work was designed to examine the protection of XMU-MP-1, an inhibitor of mammalian sterile 20-like kinase 1 (Mst1), against myocardial I/R injury in mice and investigate the...

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Veröffentlicht in:	European journal of pharmacology 2022-03, Vol.919, p.174801-174801, Article 174801
Hauptverfasser:	Liu, Yu, Chu, Guojun, Shen, Wenzhi, Zhang, Yuefan, Xu, Wei, Yu, Yongsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated protein kinase AMP-Activated Protein Kinases - metabolism Animals Apoptosis - drug effects Cardiotonic Agents - chemistry Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use Disease Models, Animal Fibrosis Inflammation Male Mammalian sterile 20-like kinase 1 Mice Mice, Inbred C57BL Mitochondrial function Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - drug effects Signal Transduction - drug effects Sulfonamides - chemistry Sulfonamides - pharmacology Sulfonamides - therapeutic use
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