Sex-specific effects of prenatal hypoxia on the cardiac endothelin system in adult offspring

Fetal hypoxia, a major consequence of complicated pregnancies, impairs offspring cardiac tolerance to ischemia-reperfusion (I/R) insult; however, the mechanisms remain unknown. Endothelin-1 (ET-1) signaling through the endothelin A receptors (ET ) is associated with cardiac dysfunction. We hypothesi...

Ausführliche Beschreibung