Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer

Genomic alterations shape cell phenotypes and the structure of tumor ecosystems in poorly defined ways. To investigate these relationships, we used imaging mass cytometry to quantify the expression of 37 proteins with subcellular spatial resolution in 483 tumors from the METABRIC cohort. Single-cell...

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Veröffentlicht in:	Nature cancer 2020-02, Vol.1 (2), p.163-175
Hauptverfasser:	Ali, H Raza, Jackson, Hartland W, Zanotelli, Vito R T, Danenberg, Esther, Fischer, Jana R, Bardwell, Helen, Provenzano, Elena, Rueda, Oscar M, Chin, Suet-Feung, Aparicio, Samuel, Caldas, Carlos, Bodenmiller, Bernd
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - diagnosis Ecosystem Female Genomics - methods Humans Image Cytometry Prognosis
Online-Zugang:	Volltext
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