Effects of a novel selective PPARα modulator, statin, sodium-glucose cotransporter 2 inhibitor, and combinatorial therapy on the liver and vasculature of medaka nonalcoholic steatohepatitis model

Nonalcoholic steatohepatitis (NASH) is a disease entity with an increasing incidence, with involvement of several metabolic pathways. Various organs, including the liver, kidneys, and the vasculature, are damaged in NASH, indicating the urgent need to develop a standard therapy. Therefore, this stud...

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Veröffentlicht in:	Biochemical and biophysical research communications 2022-03, Vol.596, p.76-82
Hauptverfasser:	Kimura, Atsushi, Kamimura, Kenya, Ohkoshi-Yamada, Marina, Shinagawa-Kobayashi, Yoko, Goto, Ryo, Owaki, Takashi, Oda, Chiyumi, Shibata, Osamu, Morita, Shinichi, Sakai, Norihiro, Abe, Hiroyuki, Yokoo, Takeshi, Sakamaki, Akira, Kamimura, Hiroteru, Terai, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Fins - blood supply Animal Fins - drug effects Animals Animals, Genetically Modified Benzhydryl Compounds - pharmacology Benzoxazoles - pharmacology Butyrates - pharmacology Diet, High-Fat - adverse effects Disease Models, Animal fli::GFP transgenic medaka Gene Ontology Glucosides - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Liver - drug effects Liver - metabolism Liver - pathology NASH Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Oryzias - genetics Oryzias - metabolism PPAR alpha - genetics PPAR alpha - metabolism Quinolines - pharmacology Reverse Transcriptase Polymerase Chain Reaction SGLT2 inhibitor Sodium-Glucose Transporter 2 Inhibitors - pharmacology SPPARMα Statin Transcriptome - drug effects Transcriptome - genetics Whole Exome Sequencing - methods
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