Design, synthesis, and biological activities of 3-((4,6-diphenylpyrimidin-2-ylamino)methylene)-2,3-dihydrochromen-4-ones

[Display omitted] •(Z)-3-((4,6-Diphenylpyrimidin-2-ylamino)methylene)-2,3-dihydrochromen-4-one derivatives were synthesized to find chemotherapeutic agents.•The title compound induced cell cycle arrest at the G1 phase and triggered apoptosis.•It upregulated the expression of endogenous cell cycle in...

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Veröffentlicht in:	Bioorganic chemistry 2022-03, Vol.120, p.105634-105634, Article 105634
Hauptverfasser:	Shin, Soon Young, Jung, Euitaek, Yeo, Hyunjin, Ahn, Seunghyun, Lee, Youngshim, Park, Jihyun, Kang, Hyunook, Yeo, Woon-Seok, Koh, Dongsoo, Lim, Yoongho
Format:	Artikel
Sprache:	eng
Schlagworte:	3-(Pyrimidin-2-ylaminomethylene)-2 3-Dihydrochromen-4-one Anti-cancer Apoptosis Aurora kinases Cell cycle arrest Clonogenic long-term survival assay
Online-Zugang:	Volltext
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