Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA

Small macrocyclic peptides are promising candidates for new anti-infective drugs. To date, such peptides have been poorly studied in the context of anti-virulence targets. Using phage display and a self-designed peptide library, we identified a cyclic heptapeptide that can bind the carbon storage re...

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Veröffentlicht in:	European journal of medicinal chemistry 2022-03, Vol.231, p.114148-114148, Article 114148
Hauptverfasser:	Jakob, Valentin, Zoller, Ben G.E., Rinkes, Julia, Wu, Yingwen, Kiefer, Alexander F., Hust, Michael, Polten, Saskia, White, Andrew M., Harvey, Peta J., Durek, Thomas, Craik, David J., Siebert, Andreas, Kazmaier, Uli, Empting, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriophages Carbon Competitive CsrA inhibition Disulfide bridges Disulfide mimetics Peptides Peptides, Cyclic - metabolism Peptides, Cyclic - pharmacology Phage display Pseudomonas aeruginosa - metabolism Triazole bridge Virulence
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