Clozapine induces astrocyte-dependent FDG-PET hypometabolism

Purpose Advances in functional imaging allowed us to visualize brain glucose metabolism in vivo and non-invasively with [ 18 F]fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) imaging. In the past decades, FDG-PET has been instrumental in the understanding of brain function in health a...

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Veröffentlicht in:	European journal of nuclear medicine and molecular imaging 2022-06, Vol.49 (7), p.2251-2264
Hauptverfasser:	Rocha, Andréia, Bellaver, Bruna, Souza, Débora G., Schu, Guilherme, Fontana, Igor C., Venturin, Gianina T., Greggio, Samuel, Fontella, Fernanda U., Schiavenin, Manoela L., Machado, Luiza S., Miron, Diogo, da Costa, Jaderson C., Rosa-Neto, Pedro, Souza, Diogo O., Pellerin, Luc, Zimmer, Eduardo R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotics Astrocytes Brain Cardiology Cell death Clozapine Clozapine - metabolism Clozapine - pharmacology Dementia disorders Deoxyglucose Evaluation Fluorodeoxyglucose F18 - metabolism Glucose Glucose - metabolism Glutamic Acid - metabolism Glutamic Acid - pharmacology Glutamic acid transporter Humans Hypometabolism Imaging Lactic acid Male Medical imaging Medicine Medicine & Public Health Metabolism Mimicry mRNA Neuroimaging Nuclear Medicine Oncology Original Article Orthopedics Positron emission Positron emission tomography Radiology Rats Rats, Wistar RNA transport Tomography
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