Unveiling idiopathic guttate hypomelanosis: pathology, immunohistochemistry, and ultrastructural study
Background Idiopathic guttate hypomelanosis (IGH) is a pigment disorder of unknown etiology. Despite its high prevalence and the unaesthetic appearance of the lesions, there are relatively few histological studies on this disorder. This is an important gap to understanding its pathogenesis. Objectiv...
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| Veröffentlicht in: | International journal of dermatology 2022-08, Vol.61 (8), p.995-1002 |
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| container_title | International journal of dermatology |
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| creator | Arbache, Samir Michalany, Nilceo S. Almeida, Hiram L. Hirata, Sergio H. |
| description | Background
Idiopathic guttate hypomelanosis (IGH) is a pigment disorder of unknown etiology. Despite its high prevalence and the unaesthetic appearance of the lesions, there are relatively few histological studies on this disorder. This is an important gap to understanding its pathogenesis.
Objectives
To assess the microscopic structure of IGH lesions compared to normal adjacent skin areas and the possible interaction between melanocytes and the subjacent dermis.
Methods
In this cross‐sectional study, we took biopsy specimens of hypochromic lesions and adjacent normal skin from 20 patients with IGH. We analyzed the fragments using routine stains, immunohistochemistry, and electron microscopy.
Results
We found superficial dermal fibrosis in 90% (18/20) of our IGH cases and unreported keratinocyte cytoplasmic changes on electron microscopy.
Conclusion
Our results suggest an interaction between melanocytes and the subjacent dermis in IGH. These findings can help to understand melanocyte biology and the pathogenesis of other achromic lesions. |
| doi_str_mv | 10.1111/ijd.16076 |
| format | Article |
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Idiopathic guttate hypomelanosis (IGH) is a pigment disorder of unknown etiology. Despite its high prevalence and the unaesthetic appearance of the lesions, there are relatively few histological studies on this disorder. This is an important gap to understanding its pathogenesis.
Objectives
To assess the microscopic structure of IGH lesions compared to normal adjacent skin areas and the possible interaction between melanocytes and the subjacent dermis.
Methods
In this cross‐sectional study, we took biopsy specimens of hypochromic lesions and adjacent normal skin from 20 patients with IGH. We analyzed the fragments using routine stains, immunohistochemistry, and electron microscopy.
Results
We found superficial dermal fibrosis in 90% (18/20) of our IGH cases and unreported keratinocyte cytoplasmic changes on electron microscopy.
Conclusion
Our results suggest an interaction between melanocytes and the subjacent dermis in IGH. These findings can help to understand melanocyte biology and the pathogenesis of other achromic lesions.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/ijd.16076</identifier><identifier>PMID: 35114009</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aetiology ; Biology ; Biopsy ; Dermis ; Electron microscopy ; Etiology ; Fibrosis ; Heavy chains ; Immunoglobulins ; Immunohistochemistry ; Lesions ; Melanocytes ; Pathogenesis ; Pathology ; Skin</subject><ispartof>International journal of dermatology, 2022-08, Vol.61 (8), p.995-1002</ispartof><rights>2022 the International Society of Dermatology.</rights><rights>International Journal of Dermatology © 2022 International Society of Dermatology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-55d514f3dcdb180401aa330e4fc6b381c009daab2174452a9e5b76a724ab51233</citedby><cites>FETCH-LOGICAL-c3536-55d514f3dcdb180401aa330e4fc6b381c009daab2174452a9e5b76a724ab51233</cites><orcidid>0000-0003-4409-4937 ; 0000-0003-4026-9664 ; 0000-0002-9300-163X ; 0000-0003-0705-1778</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijd.16076$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijd.16076$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35114009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arbache, Samir</creatorcontrib><creatorcontrib>Michalany, Nilceo S.</creatorcontrib><creatorcontrib>Almeida, Hiram L.</creatorcontrib><creatorcontrib>Hirata, Sergio H.</creatorcontrib><title>Unveiling idiopathic guttate hypomelanosis: pathology, immunohistochemistry, and ultrastructural study</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background
Idiopathic guttate hypomelanosis (IGH) is a pigment disorder of unknown etiology. Despite its high prevalence and the unaesthetic appearance of the lesions, there are relatively few histological studies on this disorder. This is an important gap to understanding its pathogenesis.
Objectives
To assess the microscopic structure of IGH lesions compared to normal adjacent skin areas and the possible interaction between melanocytes and the subjacent dermis.
Methods
In this cross‐sectional study, we took biopsy specimens of hypochromic lesions and adjacent normal skin from 20 patients with IGH. We analyzed the fragments using routine stains, immunohistochemistry, and electron microscopy.
Results
We found superficial dermal fibrosis in 90% (18/20) of our IGH cases and unreported keratinocyte cytoplasmic changes on electron microscopy.
Conclusion
Our results suggest an interaction between melanocytes and the subjacent dermis in IGH. These findings can help to understand melanocyte biology and the pathogenesis of other achromic lesions.</description><subject>Aetiology</subject><subject>Biology</subject><subject>Biopsy</subject><subject>Dermis</subject><subject>Electron microscopy</subject><subject>Etiology</subject><subject>Fibrosis</subject><subject>Heavy chains</subject><subject>Immunoglobulins</subject><subject>Immunohistochemistry</subject><subject>Lesions</subject><subject>Melanocytes</subject><subject>Pathogenesis</subject><subject>Pathology</subject><subject>Skin</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kMtLxDAQxoMouj4O_gNS8KJgNdM8ar2JbxG86LmkSbqbpW3WPJT-92Zd9SA4l2Fmfnx88yG0D_gUUp2ZuToFjku-hiZAOMspJ8U6mmAMkFeYVVto2_t5GkkBdBNtEQZAMa4mqH0d3rXpzDDNjDJ2IcLMyGwaQxBBZ7NxYXvdicF64y-y5dV2djqeZKbv42BnxgcrZ7pP3aWtGFQWu-BEGqMM0Yku8yGqcRdttKLzeu-776DX25uXq_v86fnu4eryKZeEEZ4zphjQliipGjjHFIMQhGBNW8kbcg4yeVZCNAWUlLJCVJo1JRdlQUXDoCBkBx2tdBfOvkXtQ52sSd2lF7SNvi54wTFmmEBCD_-gcxvdkNwlqoKypBVbUscrSjrrvdNtvXCmF26sAdfL8OsUfv0VfmIPvhVj02v1S_6knYCzFfBhOj3-r1Q_PF6vJD8B8wGPRQ</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>Arbache, Samir</creator><creator>Michalany, Nilceo S.</creator><creator>Almeida, Hiram L.</creator><creator>Hirata, Sergio H.</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4409-4937</orcidid><orcidid>https://orcid.org/0000-0003-4026-9664</orcidid><orcidid>https://orcid.org/0000-0002-9300-163X</orcidid><orcidid>https://orcid.org/0000-0003-0705-1778</orcidid></search><sort><creationdate>202208</creationdate><title>Unveiling idiopathic guttate hypomelanosis: pathology, immunohistochemistry, and ultrastructural study</title><author>Arbache, Samir ; Michalany, Nilceo S. ; Almeida, Hiram L. ; Hirata, Sergio H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-55d514f3dcdb180401aa330e4fc6b381c009daab2174452a9e5b76a724ab51233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aetiology</topic><topic>Biology</topic><topic>Biopsy</topic><topic>Dermis</topic><topic>Electron microscopy</topic><topic>Etiology</topic><topic>Fibrosis</topic><topic>Heavy chains</topic><topic>Immunoglobulins</topic><topic>Immunohistochemistry</topic><topic>Lesions</topic><topic>Melanocytes</topic><topic>Pathogenesis</topic><topic>Pathology</topic><topic>Skin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arbache, Samir</creatorcontrib><creatorcontrib>Michalany, Nilceo S.</creatorcontrib><creatorcontrib>Almeida, Hiram L.</creatorcontrib><creatorcontrib>Hirata, Sergio H.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arbache, Samir</au><au>Michalany, Nilceo S.</au><au>Almeida, Hiram L.</au><au>Hirata, Sergio H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unveiling idiopathic guttate hypomelanosis: pathology, immunohistochemistry, and ultrastructural study</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2022-08</date><risdate>2022</risdate><volume>61</volume><issue>8</issue><spage>995</spage><epage>1002</epage><pages>995-1002</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Background
Idiopathic guttate hypomelanosis (IGH) is a pigment disorder of unknown etiology. Despite its high prevalence and the unaesthetic appearance of the lesions, there are relatively few histological studies on this disorder. This is an important gap to understanding its pathogenesis.
Objectives
To assess the microscopic structure of IGH lesions compared to normal adjacent skin areas and the possible interaction between melanocytes and the subjacent dermis.
Methods
In this cross‐sectional study, we took biopsy specimens of hypochromic lesions and adjacent normal skin from 20 patients with IGH. We analyzed the fragments using routine stains, immunohistochemistry, and electron microscopy.
Results
We found superficial dermal fibrosis in 90% (18/20) of our IGH cases and unreported keratinocyte cytoplasmic changes on electron microscopy.
Conclusion
Our results suggest an interaction between melanocytes and the subjacent dermis in IGH. These findings can help to understand melanocyte biology and the pathogenesis of other achromic lesions.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>35114009</pmid><doi>10.1111/ijd.16076</doi><tpages>1002</tpages><orcidid>https://orcid.org/0000-0003-4409-4937</orcidid><orcidid>https://orcid.org/0000-0003-4026-9664</orcidid><orcidid>https://orcid.org/0000-0002-9300-163X</orcidid><orcidid>https://orcid.org/0000-0003-0705-1778</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Aetiology Biology Biopsy Dermis Electron microscopy Etiology Fibrosis Heavy chains Immunoglobulins Immunohistochemistry Lesions Melanocytes Pathogenesis Pathology Skin |
| title | Unveiling idiopathic guttate hypomelanosis: pathology, immunohistochemistry, and ultrastructural study |
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