Synthesis of β‑Silyl-α-amino Acid Derivatives by Cu-Catalyzed Regio- and Enantioselective Silylamination of α,β-Unsaturated Esters

A copper-catalyzed silylamination of α,β-unsaturated esters with silylboranes and hydroxylamines has been developed to afford the corresponding β-silyl-α-amino acid derivatives, which are of great interest in medicinal and pharmaceutical chemistry. Additionally, by using a suitable chiral bisphosphi...

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Veröffentlicht in:	Organic letters 2022-02, Vol.24 (6), p.1418-1422
Hauptverfasser:	Kobayashi, Toshimichi, Nishino, Soshi, Miura, Masahiro, Hirano, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	Amination Amino Acids - chemical synthesis Amino Acids - chemistry Catalysis Copper - chemistry Esters - chemistry Molecular Structure Silicon Compounds - chemical synthesis Silicon Compounds - chemistry Stereoisomerism
Online-Zugang:	Volltext
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