Comparative immunomodulatory efficacy of rosemary and fenugreek against Escherichia coli infection via suppression of inflammation and oxidative stress in broilers
Broiler chickens are frequently infected with Escherichia coli ( E. coli ) bacteria, which often leads to the emergence of many diseases and high economic losses. Hence, the current study was conducted to assess the relative efficacy of dietary rosemary and fenugreek, under E. coli infection in broi...
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| Veröffentlicht in: | Environmental science and pollution research international 2022-06, Vol.29 (26), p.40053-40067 |
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| creator | Farouk, Sameh M. Abdel-Rahman, Haidy G. Abdallah, Osama A. EL-Behidy, Nashwa G. |
| description | Broiler chickens are frequently infected with
Escherichia coli
(
E. coli
) bacteria, which often leads to the emergence of many diseases and high economic losses. Hence, the current study was conducted to assess the relative efficacy of dietary rosemary and fenugreek, under
E. coli
infection in broilers and their ability to replace antimicrobials without any loss of productivity or negative influence on broiler health, via evaluation of growth performance, biochemical indices, immune response and histo-morphological changes. Eighty Cobb broilers were allotted to four equal groups (
n
= 20 chicks/group): control non-infected (CN), control infected (CI), rosemary infected (RI) and fenugreek infected (FI) groups. The RI and FI groups revealed a significant elevation in their body weight and body weight gain compared with the CI group. However, both groups showed a significant decline in serum aspartate and alanine aminotransferase activities, as well as uric acid and creatinine levels. A significant decrease in total antioxidant capacity, catalase and superoxide dismutase activities was noted among CI chicks. Moreover, distinctly higher activities were evident in both RI and FI groups. Assessment of immunomodulatory markers showed a significant increase in immunoglobulin G along with a significant decline in interleukin-6 level in both RI and FI groups, with the lowest IL-6 value within FI group. Histopathological evaluations focused on the deleterious effect associated with
E. coli
infection of broilers’ liver, kidney, intestine, spleen, bursa of Fabricius and thymus. Partial histological improvement was noticed among RI group, and nearly normal tissues were recorded in FI group. Overall, the obtained findings suggest the ability of fenugreek to mitigate the adverse effects of
E. coli
infection on broiler performance and tissue profiles, by improving the general health status of the broiler chickens.
Graphical abstract |
| doi_str_mv | 10.1007/s11356-021-18358-6 |
| format | Article |
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Escherichia coli
(
E. coli
) bacteria, which often leads to the emergence of many diseases and high economic losses. Hence, the current study was conducted to assess the relative efficacy of dietary rosemary and fenugreek, under
E. coli
infection in broilers and their ability to replace antimicrobials without any loss of productivity or negative influence on broiler health, via evaluation of growth performance, biochemical indices, immune response and histo-morphological changes. Eighty Cobb broilers were allotted to four equal groups (
n
= 20 chicks/group): control non-infected (CN), control infected (CI), rosemary infected (RI) and fenugreek infected (FI) groups. The RI and FI groups revealed a significant elevation in their body weight and body weight gain compared with the CI group. However, both groups showed a significant decline in serum aspartate and alanine aminotransferase activities, as well as uric acid and creatinine levels. A significant decrease in total antioxidant capacity, catalase and superoxide dismutase activities was noted among CI chicks. Moreover, distinctly higher activities were evident in both RI and FI groups. Assessment of immunomodulatory markers showed a significant increase in immunoglobulin G along with a significant decline in interleukin-6 level in both RI and FI groups, with the lowest IL-6 value within FI group. Histopathological evaluations focused on the deleterious effect associated with
E. coli
infection of broilers’ liver, kidney, intestine, spleen, bursa of Fabricius and thymus. Partial histological improvement was noticed among RI group, and nearly normal tissues were recorded in FI group. Overall, the obtained findings suggest the ability of fenugreek to mitigate the adverse effects of
E. coli
infection on broiler performance and tissue profiles, by improving the general health status of the broiler chickens.
Graphical abstract</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-021-18358-6</identifier><identifier>PMID: 35112249</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Alanine ; Alanine transaminase ; Animal Feed - analysis ; Animals ; Antimicrobial agents ; Antioxidants ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Body weight ; Body weight gain ; Bursa of Fabricius ; Catalase ; Chickens ; Chicks ; Coliforms ; Creatinine ; Diet - veterinary ; Dietary Supplements ; E coli ; Earth and Environmental Science ; Economic impact ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Escherichia coli ; Escherichia coli Infections - veterinary ; Fenugreek ; IgG antibody ; Immune response ; Immune system ; Immunity ; Immunoglobulin G ; Immunomodulation ; Immunomodulators ; Infections ; Inflammation ; Interleukin 6 ; Interleukins ; Intestine ; Juveniles ; Oxidative Stress ; Performance evaluation ; Poultry ; Research Article ; Rosemary ; Rosmarinus ; Spleen ; Superoxide dismutase ; Trigonella ; Trigonella foenum-graecum ; Uric acid ; Waste Water Technology ; Water Management ; Water Pollution Control ; Weight Gain</subject><ispartof>Environmental science and pollution research international, 2022-06, Vol.29 (26), p.40053-40067</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-9ac1a6ac8344759792c55412dd1bc68ca763781c391c452b8cba251e8313c5ef3</citedby><cites>FETCH-LOGICAL-c375t-9ac1a6ac8344759792c55412dd1bc68ca763781c391c452b8cba251e8313c5ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-021-18358-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-021-18358-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35112249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farouk, Sameh M.</creatorcontrib><creatorcontrib>Abdel-Rahman, Haidy G.</creatorcontrib><creatorcontrib>Abdallah, Osama A.</creatorcontrib><creatorcontrib>EL-Behidy, Nashwa G.</creatorcontrib><title>Comparative immunomodulatory efficacy of rosemary and fenugreek against Escherichia coli infection via suppression of inflammation and oxidative stress in broilers</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Broiler chickens are frequently infected with
Escherichia coli
(
E. coli
) bacteria, which often leads to the emergence of many diseases and high economic losses. Hence, the current study was conducted to assess the relative efficacy of dietary rosemary and fenugreek, under
E. coli
infection in broilers and their ability to replace antimicrobials without any loss of productivity or negative influence on broiler health, via evaluation of growth performance, biochemical indices, immune response and histo-morphological changes. Eighty Cobb broilers were allotted to four equal groups (
n
= 20 chicks/group): control non-infected (CN), control infected (CI), rosemary infected (RI) and fenugreek infected (FI) groups. The RI and FI groups revealed a significant elevation in their body weight and body weight gain compared with the CI group. However, both groups showed a significant decline in serum aspartate and alanine aminotransferase activities, as well as uric acid and creatinine levels. A significant decrease in total antioxidant capacity, catalase and superoxide dismutase activities was noted among CI chicks. Moreover, distinctly higher activities were evident in both RI and FI groups. Assessment of immunomodulatory markers showed a significant increase in immunoglobulin G along with a significant decline in interleukin-6 level in both RI and FI groups, with the lowest IL-6 value within FI group. Histopathological evaluations focused on the deleterious effect associated with
E. coli
infection of broilers’ liver, kidney, intestine, spleen, bursa of Fabricius and thymus. Partial histological improvement was noticed among RI group, and nearly normal tissues were recorded in FI group. Overall, the obtained findings suggest the ability of fenugreek to mitigate the adverse effects of
E. coli
infection on broiler performance and tissue profiles, by improving the general health status of the broiler chickens.
Graphical abstract</description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Animal Feed - analysis</subject><subject>Animals</subject><subject>Antimicrobial agents</subject><subject>Antioxidants</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Body weight</subject><subject>Body weight gain</subject><subject>Bursa of Fabricius</subject><subject>Catalase</subject><subject>Chickens</subject><subject>Chicks</subject><subject>Coliforms</subject><subject>Creatinine</subject><subject>Diet - veterinary</subject><subject>Dietary Supplements</subject><subject>E coli</subject><subject>Earth and Environmental Science</subject><subject>Economic impact</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Escherichia coli</subject><subject>Escherichia coli Infections - veterinary</subject><subject>Fenugreek</subject><subject>IgG antibody</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunity</subject><subject>Immunoglobulin G</subject><subject>Immunomodulation</subject><subject>Immunomodulators</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Interleukins</subject><subject>Intestine</subject><subject>Juveniles</subject><subject>Oxidative Stress</subject><subject>Performance evaluation</subject><subject>Poultry</subject><subject>Research Article</subject><subject>Rosemary</subject><subject>Rosmarinus</subject><subject>Spleen</subject><subject>Superoxide dismutase</subject><subject>Trigonella</subject><subject>Trigonella foenum-graecum</subject><subject>Uric acid</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>Weight 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immunomodulatory efficacy of rosemary and fenugreek against Escherichia coli infection via suppression of inflammation and oxidative stress in broilers</title><author>Farouk, Sameh M. ; Abdel-Rahman, Haidy G. ; Abdallah, Osama A. ; EL-Behidy, Nashwa G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-9ac1a6ac8344759792c55412dd1bc68ca763781c391c452b8cba251e8313c5ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Animal Feed - analysis</topic><topic>Animals</topic><topic>Antimicrobial agents</topic><topic>Antioxidants</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Body weight</topic><topic>Body weight gain</topic><topic>Bursa of 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evaluation</topic><topic>Poultry</topic><topic>Research Article</topic><topic>Rosemary</topic><topic>Rosmarinus</topic><topic>Spleen</topic><topic>Superoxide dismutase</topic><topic>Trigonella</topic><topic>Trigonella foenum-graecum</topic><topic>Uric acid</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farouk, Sameh M.</creatorcontrib><creatorcontrib>Abdel-Rahman, Haidy G.</creatorcontrib><creatorcontrib>Abdallah, Osama A.</creatorcontrib><creatorcontrib>EL-Behidy, Nashwa G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts 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Int</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>29</volume><issue>26</issue><spage>40053</spage><epage>40067</epage><pages>40053-40067</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Broiler chickens are frequently infected with
Escherichia coli
(
E. coli
) bacteria, which often leads to the emergence of many diseases and high economic losses. Hence, the current study was conducted to assess the relative efficacy of dietary rosemary and fenugreek, under
E. coli
infection in broilers and their ability to replace antimicrobials without any loss of productivity or negative influence on broiler health, via evaluation of growth performance, biochemical indices, immune response and histo-morphological changes. Eighty Cobb broilers were allotted to four equal groups (
n
= 20 chicks/group): control non-infected (CN), control infected (CI), rosemary infected (RI) and fenugreek infected (FI) groups. The RI and FI groups revealed a significant elevation in their body weight and body weight gain compared with the CI group. However, both groups showed a significant decline in serum aspartate and alanine aminotransferase activities, as well as uric acid and creatinine levels. A significant decrease in total antioxidant capacity, catalase and superoxide dismutase activities was noted among CI chicks. Moreover, distinctly higher activities were evident in both RI and FI groups. Assessment of immunomodulatory markers showed a significant increase in immunoglobulin G along with a significant decline in interleukin-6 level in both RI and FI groups, with the lowest IL-6 value within FI group. Histopathological evaluations focused on the deleterious effect associated with
E. coli
infection of broilers’ liver, kidney, intestine, spleen, bursa of Fabricius and thymus. Partial histological improvement was noticed among RI group, and nearly normal tissues were recorded in FI group. Overall, the obtained findings suggest the ability of fenugreek to mitigate the adverse effects of
E. coli
infection on broiler performance and tissue profiles, by improving the general health status of the broiler chickens.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35112249</pmid><doi>10.1007/s11356-021-18358-6</doi><tpages>15</tpages></addata></record> |
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| ispartof | Environmental science and pollution research international, 2022-06, Vol.29 (26), p.40053-40067 |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Alanine Alanine transaminase Animal Feed - analysis Animals Antimicrobial agents Antioxidants Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Body weight Body weight gain Bursa of Fabricius Catalase Chickens Chicks Coliforms Creatinine Diet - veterinary Dietary Supplements E coli Earth and Environmental Science Economic impact Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Escherichia coli Escherichia coli Infections - veterinary Fenugreek IgG antibody Immune response Immune system Immunity Immunoglobulin G Immunomodulation Immunomodulators Infections Inflammation Interleukin 6 Interleukins Intestine Juveniles Oxidative Stress Performance evaluation Poultry Research Article Rosemary Rosmarinus Spleen Superoxide dismutase Trigonella Trigonella foenum-graecum Uric acid Waste Water Technology Water Management Water Pollution Control Weight Gain |
| title | Comparative immunomodulatory efficacy of rosemary and fenugreek against Escherichia coli infection via suppression of inflammation and oxidative stress in broilers |
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