Application of the All-Hydrocarbon Stapling Technique in the Design of Membrane-Active Peptides

The threats of drug resistance and new emerging pathogens have led to an urgent need to develop alternative treatment therapies. Recently, considerable research efforts have focused on membrane-active peptides (MAPs), a category of peptides in drug discovery with antimicrobial, anticancer, and cell...

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Veröffentlicht in:	Journal of medicinal chemistry 2022-02, Vol.65 (4), p.3026-3045
Hauptverfasser:	Luong, Huy Xuan, Bui, Hai Thi Phuong, Tung, Truong Thanh
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents Chemistry, Organic - methods Drug Design - methods Drug Discovery Humans Hydrocarbons - chemistry Membranes - drug effects Peptides - chemical synthesis Peptides - pharmacology Protein Conformation, alpha-Helical Protein Structure, Secondary
Online-Zugang:	Volltext
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