Impaired p47phox phosphorylation in neutrophils from patients with p67phox-deficient chronic granulomatous disease

Superoxide production by the phagocyte reduced NAD phosphate (NADPH) oxidase is essential for innate immunity as shown in chronic granulomatous disease (CGD), an immunodeficiency disease resulting from mutations in 1 of its genes. The NADPH oxidase is composed of 2 membrane proteins (gp91phox/NOX2 a...

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Veröffentlicht in:	Blood 2022-04, Vol.139 (16), p.2512-2522
Hauptverfasser:	Belambri, Sahra Amel, Marzaioli, Viviana, Hurtado-Nedelec, Margarita, Pintard, Coralie, Liang, Shiyu, Liu, Yezhou, Boussetta, Tarek, Gougerot-Pocidalo, Marie-Anne, Ye, Richard D., Dang, Pham My-Chan, El-Benna, Jamel
Format:	Artikel
Sprache:	eng
Schlagworte:	Enzyme Activation Epstein-Barr Virus Infections - metabolism Granulomatous Disease, Chronic - genetics Herpesvirus 4, Human - metabolism Humans NADPH Oxidases - genetics NADPH Oxidases - metabolism Neutrophils - metabolism Phosphoproteins - genetics Phosphoproteins - metabolism Phosphorylation
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