The Role of Calorie Restriction in the Prevention of Cardiovascular Disease
Purpose of Review Calorie restriction (CR) has emerged as a non-pharmacological treatment to prevent cardiovascular disease (CVD). This article reviews recent progress regarding the role of CR in CVD prevention via reduction of cardiometabolic risk factors and promoting atherosclerotic stability. Re...
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Veröffentlicht in: | Current atherosclerosis reports 2022-04, Vol.24 (4), p.235-242 |
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creator | Perry, Cydne A. Gadde, Kishore M. |
description | Purpose of Review
Calorie restriction (CR) has emerged as a non-pharmacological treatment to prevent cardiovascular disease (CVD). This article reviews recent progress regarding the role of CR in CVD prevention via reduction of cardiometabolic risk factors and promoting atherosclerotic stability.
Recent Findings
Calorie restriction may be an approach to reduce the development of atherosclerosis. CR promotes eNOS activity and SIRT1 expression which in turn improves vasodilation resulting in greater regulation of blood pressure and blood flow. Modest CR in nonobese young and middle-aged adults results in improved cardiometabolic risk profile.
Summary
The evidence for CR in CVD prevention has accumulated in the recent years. Most evidence, however, is from rodent or small human trials. Our understanding of the magnitude of calorie reduction that leads to the long-term therapeutic effects on cardiovascular health is limited. More well-designed controlled trials conducted in diverse populations with larger sample sizes and longer follow-ups are warranted. |
doi_str_mv | 10.1007/s11883-022-00999-8 |
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Calorie restriction (CR) has emerged as a non-pharmacological treatment to prevent cardiovascular disease (CVD). This article reviews recent progress regarding the role of CR in CVD prevention via reduction of cardiometabolic risk factors and promoting atherosclerotic stability.
Recent Findings
Calorie restriction may be an approach to reduce the development of atherosclerosis. CR promotes eNOS activity and SIRT1 expression which in turn improves vasodilation resulting in greater regulation of blood pressure and blood flow. Modest CR in nonobese young and middle-aged adults results in improved cardiometabolic risk profile.
Summary
The evidence for CR in CVD prevention has accumulated in the recent years. Most evidence, however, is from rodent or small human trials. Our understanding of the magnitude of calorie reduction that leads to the long-term therapeutic effects on cardiovascular health is limited. More well-designed controlled trials conducted in diverse populations with larger sample sizes and longer follow-ups are warranted.</description><identifier>ISSN: 1523-3804</identifier><identifier>EISSN: 1534-6242</identifier><identifier>DOI: 10.1007/s11883-022-00999-8</identifier><identifier>PMID: 35107761</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Angiology ; Blood Pressure ; Caloric Restriction ; Cardiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - prevention & control ; Energy Intake ; Humans ; Medicine ; Medicine & Public Health ; Middle Aged ; Nutrition (K. Petersen ; Section Editor ; Topical Collection on Nutrition ; Vasodilation</subject><ispartof>Current atherosclerosis reports, 2022-04, Vol.24 (4), p.235-242</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c277t-7387955179a98638d467d75eb8fb0c2fc1f6ec676ab74b83f18bc2805615303c3</citedby><cites>FETCH-LOGICAL-c277t-7387955179a98638d467d75eb8fb0c2fc1f6ec676ab74b83f18bc2805615303c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11883-022-00999-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11883-022-00999-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35107761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perry, Cydne A.</creatorcontrib><creatorcontrib>Gadde, Kishore M.</creatorcontrib><title>The Role of Calorie Restriction in the Prevention of Cardiovascular Disease</title><title>Current atherosclerosis reports</title><addtitle>Curr Atheroscler Rep</addtitle><addtitle>Curr Atheroscler Rep</addtitle><description>Purpose of Review
Calorie restriction (CR) has emerged as a non-pharmacological treatment to prevent cardiovascular disease (CVD). This article reviews recent progress regarding the role of CR in CVD prevention via reduction of cardiometabolic risk factors and promoting atherosclerotic stability.
Recent Findings
Calorie restriction may be an approach to reduce the development of atherosclerosis. CR promotes eNOS activity and SIRT1 expression which in turn improves vasodilation resulting in greater regulation of blood pressure and blood flow. Modest CR in nonobese young and middle-aged adults results in improved cardiometabolic risk profile.
Summary
The evidence for CR in CVD prevention has accumulated in the recent years. Most evidence, however, is from rodent or small human trials. Our understanding of the magnitude of calorie reduction that leads to the long-term therapeutic effects on cardiovascular health is limited. More well-designed controlled trials conducted in diverse populations with larger sample sizes and longer follow-ups are warranted.</description><subject>Angiology</subject><subject>Blood Pressure</subject><subject>Caloric Restriction</subject><subject>Cardiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Energy Intake</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nutrition (K. Petersen</subject><subject>Section Editor</subject><subject>Topical Collection on Nutrition</subject><subject>Vasodilation</subject><issn>1523-3804</issn><issn>1534-6242</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPxCAYRYnROOPoH3BhunSDfkALdGnGZ5xEY8Y1oZQqk04ZoZ3Efy_z0KUrXue74R6EzglcEQBxHQmRkmGgFAOUZYnlARqTguWY05webvaUYSYhH6GTGBcAFCQnx2jECgJCcDJGz_NPm7351ma-yaa69cGls419cKZ3vstcl_UJeQ12bbvtzRYMtfNrHc3Q6pDdumh1tKfoqNFttGf7dYLe7-_m00c8e3l4mt7MsKFC9FgwKcqiIKLUpeRM1jkXtShsJZsKDG0Mabg1XHBdibySrCGyMlRCwVM3YIZN0OUudxX815D-qpYuGtu2urN-iIqm-mXSUPCE0h1qgo8x2Eatglvq8K0IqI1EtZOokkS1lahkGrrY5w_V0tZ_I7_WEsB2QExP3YcNauGH0KXO_8X-AOR7e58</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Perry, Cydne A.</creator><creator>Gadde, Kishore M.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202204</creationdate><title>The Role of Calorie Restriction in the Prevention of Cardiovascular Disease</title><author>Perry, Cydne A. ; Gadde, Kishore M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c277t-7387955179a98638d467d75eb8fb0c2fc1f6ec676ab74b83f18bc2805615303c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Angiology</topic><topic>Blood Pressure</topic><topic>Caloric Restriction</topic><topic>Cardiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Energy Intake</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nutrition (K. Petersen</topic><topic>Section Editor</topic><topic>Topical Collection on Nutrition</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perry, Cydne A.</creatorcontrib><creatorcontrib>Gadde, Kishore M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current atherosclerosis reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perry, Cydne A.</au><au>Gadde, Kishore M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Calorie Restriction in the Prevention of Cardiovascular Disease</atitle><jtitle>Current atherosclerosis reports</jtitle><stitle>Curr Atheroscler Rep</stitle><addtitle>Curr Atheroscler Rep</addtitle><date>2022-04</date><risdate>2022</risdate><volume>24</volume><issue>4</issue><spage>235</spage><epage>242</epage><pages>235-242</pages><issn>1523-3804</issn><eissn>1534-6242</eissn><abstract>Purpose of Review
Calorie restriction (CR) has emerged as a non-pharmacological treatment to prevent cardiovascular disease (CVD). This article reviews recent progress regarding the role of CR in CVD prevention via reduction of cardiometabolic risk factors and promoting atherosclerotic stability.
Recent Findings
Calorie restriction may be an approach to reduce the development of atherosclerosis. CR promotes eNOS activity and SIRT1 expression which in turn improves vasodilation resulting in greater regulation of blood pressure and blood flow. Modest CR in nonobese young and middle-aged adults results in improved cardiometabolic risk profile.
Summary
The evidence for CR in CVD prevention has accumulated in the recent years. Most evidence, however, is from rodent or small human trials. Our understanding of the magnitude of calorie reduction that leads to the long-term therapeutic effects on cardiovascular health is limited. More well-designed controlled trials conducted in diverse populations with larger sample sizes and longer follow-ups are warranted.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35107761</pmid><doi>10.1007/s11883-022-00999-8</doi><tpages>8</tpages></addata></record> |
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source | MEDLINE; SpringerNature Journals |
subjects | Angiology Blood Pressure Caloric Restriction Cardiology Cardiovascular Diseases - etiology Cardiovascular Diseases - prevention & control Energy Intake Humans Medicine Medicine & Public Health Middle Aged Nutrition (K. Petersen Section Editor Topical Collection on Nutrition Vasodilation |
title | The Role of Calorie Restriction in the Prevention of Cardiovascular Disease |
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