Peony seed oil decreases plasma cholesterol and favorably modulates gut microbiota in hypercholesterolemic hamsters
Purpose Peony ( Paeonia spp.) seed oil (PSO) contains a high amount of α-linolenic acid. The effects of PSO on hypercholesterolemia and gut microbiota remains unclear. The present study was to investigate effects of PSO supplementation on cholesterol metabolism and modulation of the gut microbiota....
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| Veröffentlicht in: | European journal of nutrition 2022-08, Vol.61 (5), p.2341-2356 |
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| container_title | European journal of nutrition |
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| creator | Kwek, Erika Zhu, Hanyue Ding, Huafang He, Zouyan Hao, Wangjun Liu, Jianhui Ma, Ka Ying Chen, Zhen-Yu |
| description | Purpose
Peony (
Paeonia
spp.) seed oil (PSO) contains a high amount of α-linolenic acid. The effects of PSO on hypercholesterolemia and gut microbiota remains unclear. The present study was to investigate effects of PSO supplementation on cholesterol metabolism and modulation of the gut microbiota.
Methods
Male Golden Syrian hamsters (
n
= 40) were randomly divided into five groups (
n
= 8, each) fed one of the following diets namely low-cholesterol diet (LCD); high cholesterol diet (HCD); HCD with PSO substituting 50% lard (LPSO), PSO substituting 100% lard (HPSO) and HCD with addition of 0.5% cholestyramine (PCD), respectively, for 6 weeks.
Results
PSO supplementation dose-dependently reduced plasma total cholesterol (TC) by 9–14%, non-high-density lipoprotein cholesterol (non-HDL-C) by 7–18% and triacylglycerols (TG) by 14–34% (
p
|
| doi_str_mv | 10.1007/s00394-021-02785-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2624952425</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2688768781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-621df13d3177712be0718eb673ac4375db53a53c1c4557baf139b4e7f04a3e1b3</originalsourceid><addsrcrecordid>eNp9kctOwzAQRS0EoqXwAyyQJTZsAn7EcbJEFS-pEixgbdnJpE3lxMVOkPr3uLQUxIKFZVtz7p0ZXYTOKbmmhMibQAgv0oQwGo_MRVIcoDFNeZZkjIrD_ZvIEToJYUkIYTyjx2jEBSUyY2KMwgu4bo0DQIVdY3EFpQcdIOCV1aHVuFw4C6EH7yzWXYVr_eG8NnaNW1cNVvcRnQ89bpvSO9O4XuOmw4v1CvwvKcQyXuh28wun6KjWNsDZ7p6gt_u71-ljMnt-eJrezpKSS9FvlqhqyitOpZSUGSCS5mAyyXWZRqIygmvBS1qmQkijI1uYFGRNUs2BGj5BV1vflXfvQ5xEtU0owVrdgRuCYhlLC8FSJiJ6-QddusF3cbpI5bnMcpnTSLEtFVcNwUOtVr5ptV8rStQmErWNRMVI1Fckqoiii531YFqo9pLvDCLAt0CIpW4O_qf3P7afD3yYYA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2688768781</pqid></control><display><type>article</type><title>Peony seed oil decreases plasma cholesterol and favorably modulates gut microbiota in hypercholesterolemic hamsters</title><source>Springer Nature - Complete Springer Journals</source><creator>Kwek, Erika ; Zhu, Hanyue ; Ding, Huafang ; He, Zouyan ; Hao, Wangjun ; Liu, Jianhui ; Ma, Ka Ying ; Chen, Zhen-Yu</creator><creatorcontrib>Kwek, Erika ; Zhu, Hanyue ; Ding, Huafang ; He, Zouyan ; Hao, Wangjun ; Liu, Jianhui ; Ma, Ka Ying ; Chen, Zhen-Yu</creatorcontrib><description>Purpose
Peony (
Paeonia
spp.) seed oil (PSO) contains a high amount of α-linolenic acid. The effects of PSO on hypercholesterolemia and gut microbiota remains unclear. The present study was to investigate effects of PSO supplementation on cholesterol metabolism and modulation of the gut microbiota.
Methods
Male Golden Syrian hamsters (
n
= 40) were randomly divided into five groups (
n
= 8, each) fed one of the following diets namely low-cholesterol diet (LCD); high cholesterol diet (HCD); HCD with PSO substituting 50% lard (LPSO), PSO substituting 100% lard (HPSO) and HCD with addition of 0.5% cholestyramine (PCD), respectively, for 6 weeks.
Results
PSO supplementation dose-dependently reduced plasma total cholesterol (TC) by 9–14%, non-high-density lipoprotein cholesterol (non-HDL-C) by 7–18% and triacylglycerols (TG) by 14–34% (
p
< 0.05). In addition, feeding PSO diets reduced the formation of plaque lesions by 49–61% and hepatic lipids by 9–19% compared with feeding HCD diet (
p
< 0.01). PSO also altered relative genus abundance of
unclassified_f__Coriobacteriaceae
,
unclassified_f__Erysipelotrichaceae, Peptococcus, unclassified_f__Ruminococcaceae, norank_o__Mollicutes_RF9
and
Christensenellaceae_R-7_group
.
Conclusions
It was concluded that PSO was effective in reducing plasma cholesterol and hepatic lipids and favorably modulating gut microbiota associated with cholesterol metabolism.
Graphical abstract</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-021-02785-9</identifier><identifier>PMID: 35107625</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Chemistry ; Chemistry and Materials Science ; Cholesterol ; Diet ; High cholesterol diet ; High density lipoprotein ; Hypercholesterolemia ; Intestinal microflora ; Linolenic acid ; Lipid metabolism ; Liver ; Metabolism ; Microbiota ; Nutrient deficiency ; Nutrition ; Oilseeds ; Original Contribution</subject><ispartof>European journal of nutrition, 2022-08, Vol.61 (5), p.2341-2356</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-621df13d3177712be0718eb673ac4375db53a53c1c4557baf139b4e7f04a3e1b3</citedby><cites>FETCH-LOGICAL-c375t-621df13d3177712be0718eb673ac4375db53a53c1c4557baf139b4e7f04a3e1b3</cites><orcidid>0000-0001-5615-1682</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-021-02785-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-021-02785-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35107625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwek, Erika</creatorcontrib><creatorcontrib>Zhu, Hanyue</creatorcontrib><creatorcontrib>Ding, Huafang</creatorcontrib><creatorcontrib>He, Zouyan</creatorcontrib><creatorcontrib>Hao, Wangjun</creatorcontrib><creatorcontrib>Liu, Jianhui</creatorcontrib><creatorcontrib>Ma, Ka Ying</creatorcontrib><creatorcontrib>Chen, Zhen-Yu</creatorcontrib><title>Peony seed oil decreases plasma cholesterol and favorably modulates gut microbiota in hypercholesterolemic hamsters</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
Peony (
Paeonia
spp.) seed oil (PSO) contains a high amount of α-linolenic acid. The effects of PSO on hypercholesterolemia and gut microbiota remains unclear. The present study was to investigate effects of PSO supplementation on cholesterol metabolism and modulation of the gut microbiota.
Methods
Male Golden Syrian hamsters (
n
= 40) were randomly divided into five groups (
n
= 8, each) fed one of the following diets namely low-cholesterol diet (LCD); high cholesterol diet (HCD); HCD with PSO substituting 50% lard (LPSO), PSO substituting 100% lard (HPSO) and HCD with addition of 0.5% cholestyramine (PCD), respectively, for 6 weeks.
Results
PSO supplementation dose-dependently reduced plasma total cholesterol (TC) by 9–14%, non-high-density lipoprotein cholesterol (non-HDL-C) by 7–18% and triacylglycerols (TG) by 14–34% (
p
< 0.05). In addition, feeding PSO diets reduced the formation of plaque lesions by 49–61% and hepatic lipids by 9–19% compared with feeding HCD diet (
p
< 0.01). PSO also altered relative genus abundance of
unclassified_f__Coriobacteriaceae
,
unclassified_f__Erysipelotrichaceae, Peptococcus, unclassified_f__Ruminococcaceae, norank_o__Mollicutes_RF9
and
Christensenellaceae_R-7_group
.
Conclusions
It was concluded that PSO was effective in reducing plasma cholesterol and hepatic lipids and favorably modulating gut microbiota associated with cholesterol metabolism.
Graphical abstract</description><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cholesterol</subject><subject>Diet</subject><subject>High cholesterol diet</subject><subject>High density lipoprotein</subject><subject>Hypercholesterolemia</subject><subject>Intestinal microflora</subject><subject>Linolenic acid</subject><subject>Lipid metabolism</subject><subject>Liver</subject><subject>Metabolism</subject><subject>Microbiota</subject><subject>Nutrient deficiency</subject><subject>Nutrition</subject><subject>Oilseeds</subject><subject>Original Contribution</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kctOwzAQRS0EoqXwAyyQJTZsAn7EcbJEFS-pEixgbdnJpE3lxMVOkPr3uLQUxIKFZVtz7p0ZXYTOKbmmhMibQAgv0oQwGo_MRVIcoDFNeZZkjIrD_ZvIEToJYUkIYTyjx2jEBSUyY2KMwgu4bo0DQIVdY3EFpQcdIOCV1aHVuFw4C6EH7yzWXYVr_eG8NnaNW1cNVvcRnQ89bpvSO9O4XuOmw4v1CvwvKcQyXuh28wun6KjWNsDZ7p6gt_u71-ljMnt-eJrezpKSS9FvlqhqyitOpZSUGSCS5mAyyXWZRqIygmvBS1qmQkijI1uYFGRNUs2BGj5BV1vflXfvQ5xEtU0owVrdgRuCYhlLC8FSJiJ6-QddusF3cbpI5bnMcpnTSLEtFVcNwUOtVr5ptV8rStQmErWNRMVI1Fckqoiii531YFqo9pLvDCLAt0CIpW4O_qf3P7afD3yYYA</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Kwek, Erika</creator><creator>Zhu, Hanyue</creator><creator>Ding, Huafang</creator><creator>He, Zouyan</creator><creator>Hao, Wangjun</creator><creator>Liu, Jianhui</creator><creator>Ma, Ka Ying</creator><creator>Chen, Zhen-Yu</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5615-1682</orcidid></search><sort><creationdate>20220801</creationdate><title>Peony seed oil decreases plasma cholesterol and favorably modulates gut microbiota in hypercholesterolemic hamsters</title><author>Kwek, Erika ; Zhu, Hanyue ; Ding, Huafang ; He, Zouyan ; Hao, Wangjun ; Liu, Jianhui ; Ma, Ka Ying ; Chen, Zhen-Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-621df13d3177712be0718eb673ac4375db53a53c1c4557baf139b4e7f04a3e1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Cholesterol</topic><topic>Diet</topic><topic>High cholesterol diet</topic><topic>High density lipoprotein</topic><topic>Hypercholesterolemia</topic><topic>Intestinal microflora</topic><topic>Linolenic acid</topic><topic>Lipid metabolism</topic><topic>Liver</topic><topic>Metabolism</topic><topic>Microbiota</topic><topic>Nutrient deficiency</topic><topic>Nutrition</topic><topic>Oilseeds</topic><topic>Original Contribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwek, Erika</creatorcontrib><creatorcontrib>Zhu, Hanyue</creatorcontrib><creatorcontrib>Ding, Huafang</creatorcontrib><creatorcontrib>He, Zouyan</creatorcontrib><creatorcontrib>Hao, Wangjun</creatorcontrib><creatorcontrib>Liu, Jianhui</creatorcontrib><creatorcontrib>Ma, Ka Ying</creatorcontrib><creatorcontrib>Chen, Zhen-Yu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwek, Erika</au><au>Zhu, Hanyue</au><au>Ding, Huafang</au><au>He, Zouyan</au><au>Hao, Wangjun</au><au>Liu, Jianhui</au><au>Ma, Ka Ying</au><au>Chen, Zhen-Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peony seed oil decreases plasma cholesterol and favorably modulates gut microbiota in hypercholesterolemic hamsters</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>61</volume><issue>5</issue><spage>2341</spage><epage>2356</epage><pages>2341-2356</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
Peony (
Paeonia
spp.) seed oil (PSO) contains a high amount of α-linolenic acid. The effects of PSO on hypercholesterolemia and gut microbiota remains unclear. The present study was to investigate effects of PSO supplementation on cholesterol metabolism and modulation of the gut microbiota.
Methods
Male Golden Syrian hamsters (
n
= 40) were randomly divided into five groups (
n
= 8, each) fed one of the following diets namely low-cholesterol diet (LCD); high cholesterol diet (HCD); HCD with PSO substituting 50% lard (LPSO), PSO substituting 100% lard (HPSO) and HCD with addition of 0.5% cholestyramine (PCD), respectively, for 6 weeks.
Results
PSO supplementation dose-dependently reduced plasma total cholesterol (TC) by 9–14%, non-high-density lipoprotein cholesterol (non-HDL-C) by 7–18% and triacylglycerols (TG) by 14–34% (
p
< 0.05). In addition, feeding PSO diets reduced the formation of plaque lesions by 49–61% and hepatic lipids by 9–19% compared with feeding HCD diet (
p
< 0.01). PSO also altered relative genus abundance of
unclassified_f__Coriobacteriaceae
,
unclassified_f__Erysipelotrichaceae, Peptococcus, unclassified_f__Ruminococcaceae, norank_o__Mollicutes_RF9
and
Christensenellaceae_R-7_group
.
Conclusions
It was concluded that PSO was effective in reducing plasma cholesterol and hepatic lipids and favorably modulating gut microbiota associated with cholesterol metabolism.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35107625</pmid><doi>10.1007/s00394-021-02785-9</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0001-5615-1682</orcidid></addata></record> |
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| ispartof | European journal of nutrition, 2022-08, Vol.61 (5), p.2341-2356 |
| issn | 1436-6207 1436-6215 |
| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Chemistry Chemistry and Materials Science Cholesterol Diet High cholesterol diet High density lipoprotein Hypercholesterolemia Intestinal microflora Linolenic acid Lipid metabolism Liver Metabolism Microbiota Nutrient deficiency Nutrition Oilseeds Original Contribution |
| title | Peony seed oil decreases plasma cholesterol and favorably modulates gut microbiota in hypercholesterolemic hamsters |
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