Exploring graphene oxide intrinsic electroactivity to elucidate the non-covalent interactions with DNA oligonucleotides

Exploring graphene oxide intrinsic electroactivity to elucidate the non-covalent interactions with DNA oligonucleotides

We show here how the electrochemical reduction signal of graphene oxide nanocolloids is inhibited upon the formation of non-covalent interactions with single stranded DNA oligonucleotides. The drop in the reduction current intensity is strongly influenced by the nucleobase sequence, and can therefor...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-02, Vol.58 (16), p.2662-2665
Hauptverfasser: Liang, Yaquan, Ang, Wei Li, Lim, Rachel Rui Xia, Bonanni, Alessandra
Format: Artikel
Sprache:eng
Schlagworte:
Biosensing Techniques
Chemical reduction
DNA - chemistry
Electroactivity
Electrochemical Techniques
Graphene
Graphite - chemistry
Oligonucleotides
Oligonucleotides - chemistry
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Zusammenfassung:We show here how the electrochemical reduction signal of graphene oxide nanocolloids is inhibited upon the formation of non-covalent interactions with single stranded DNA oligonucleotides. The drop in the reduction current intensity is strongly influenced by the nucleobase sequence, and can therefore be directly correlated to the specific DNA homo-oligonucleotide.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc06657a