Short-term exposure to pharmaceuticals negatively impacts marine flatfish species: Histological, biochemical and molecular clues for an integrated ecosystem risk assessment
The marine habitat and its biodiversity can be impacted by released pharmaceuticals. The short-term (7 days) effect of 3 commonly used drugs – warfarin, dexamethasone and imidazole – on Senegalese sole (Solea senegalensis) juveniles was investigated. Occurrence of hemorrhages, histopathological alte...
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| Veröffentlicht in: | Environmental toxicology and pharmacology 2022-02, Vol.90, p.103822-103822, Article 103822 |
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| creator | Pes, Katia Ortiz-Delgado, Juan B. Sarasquete, Carmen Laizé, Vincent Fernández, Ignacio |
| description | The marine habitat and its biodiversity can be impacted by released pharmaceuticals. The short-term (7 days) effect of 3 commonly used drugs – warfarin, dexamethasone and imidazole – on Senegalese sole (Solea senegalensis) juveniles was investigated. Occurrence of hemorrhages, histopathological alterations, antioxidant status, activity of antioxidant enzymes and expression of genes involved in the xenobiotic response (pxr, abcb1 and cyp1a), were evaluated. The results showed a time and drug-dependent effect. Warfarin exposure induced hemorrhages, hepatocyte vacuolar degeneration, and altered the activity of glutathione peroxidase (GPx) and the expression of all the studied genes. Dexamethasone exposure increased liver glycogen content, altered antioxidant status, GPx and superoxide dismutase activities, as well as abcb1 and cyp1a expression. Imidazole induced hepatocyte vacuolar degeneration and ballooning, and altered the antioxidant status and expression of the tested genes. The present work anticipates a deeper impact of pharmaceuticals on the aquatic environment than previously reported, thus underlining the urgent need for an integrated risk assessment.
•Warfarin, dexamethasone and imidazole are PPCPs which release has environmental concerns.•Short-term exposure of warfarin, dexamethasone and imidazole induced liver damage.•A specific antioxidant response to drug exposure was revealed.•Each drug altered the expression of the pregnane X receptor. |
| doi_str_mv | 10.1016/j.etap.2022.103822 |
| format | Article |
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•Warfarin, dexamethasone and imidazole are PPCPs which release has environmental concerns.•Short-term exposure of warfarin, dexamethasone and imidazole induced liver damage.•A specific antioxidant response to drug exposure was revealed.•Each drug altered the expression of the pregnane X receptor.</description><identifier>ISSN: 1382-6689</identifier><identifier>EISSN: 1872-7077</identifier><identifier>DOI: 10.1016/j.etap.2022.103822</identifier><identifier>PMID: 35101594</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antioxidant enzyme activity ; Antioxidants ; Antioxidants - analysis ; Aquatic environment ; Aquatic habitats ; Aquatic toxicology ; Biodiversity ; CYP1A protein ; Cytochrome P450 ; Degeneration ; Dexamethasone ; Dexamethasone - toxicity ; Drug dependence ; Exposure ; Fish ; Flatfishes ; Gene expression ; Genes ; Glutathione ; Glutathione peroxidase ; Glycogen ; Glycogens ; Hemorrhage ; Hemorrhage - chemically induced ; Imidazole ; Imidazoles - toxicity ; Liver - drug effects ; Marine ecosystems ; Peroxidase ; Pharmaceuticals ; Risk Assessment ; Superoxide dismutase ; Transcriptome ; Vertebrates ; Warfarin ; Warfarin - toxicity ; Water Pollutants, Chemical - toxicity</subject><ispartof>Environmental toxicology and pharmacology, 2022-02, Vol.90, p.103822-103822, Article 103822</ispartof><rights>2022 The Authors</rights><rights>Copyright © 2022 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Feb 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-d1cd430121062c6c5806c556293be9651317ad38b5bc81cec2d5ac168fc9614f3</citedby><cites>FETCH-LOGICAL-c428t-d1cd430121062c6c5806c556293be9651317ad38b5bc81cec2d5ac168fc9614f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.etap.2022.103822$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35101594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pes, Katia</creatorcontrib><creatorcontrib>Ortiz-Delgado, Juan B.</creatorcontrib><creatorcontrib>Sarasquete, Carmen</creatorcontrib><creatorcontrib>Laizé, Vincent</creatorcontrib><creatorcontrib>Fernández, Ignacio</creatorcontrib><title>Short-term exposure to pharmaceuticals negatively impacts marine flatfish species: Histological, biochemical and molecular clues for an integrated ecosystem risk assessment</title><title>Environmental toxicology and pharmacology</title><addtitle>Environ Toxicol Pharmacol</addtitle><description>The marine habitat and its biodiversity can be impacted by released pharmaceuticals. The short-term (7 days) effect of 3 commonly used drugs – warfarin, dexamethasone and imidazole – on Senegalese sole (Solea senegalensis) juveniles was investigated. Occurrence of hemorrhages, histopathological alterations, antioxidant status, activity of antioxidant enzymes and expression of genes involved in the xenobiotic response (pxr, abcb1 and cyp1a), were evaluated. The results showed a time and drug-dependent effect. Warfarin exposure induced hemorrhages, hepatocyte vacuolar degeneration, and altered the activity of glutathione peroxidase (GPx) and the expression of all the studied genes. Dexamethasone exposure increased liver glycogen content, altered antioxidant status, GPx and superoxide dismutase activities, as well as abcb1 and cyp1a expression. Imidazole induced hepatocyte vacuolar degeneration and ballooning, and altered the antioxidant status and expression of the tested genes. The present work anticipates a deeper impact of pharmaceuticals on the aquatic environment than previously reported, thus underlining the urgent need for an integrated risk assessment.
•Warfarin, dexamethasone and imidazole are PPCPs which release has environmental concerns.•Short-term exposure of warfarin, dexamethasone and imidazole induced liver damage.•A specific antioxidant response to drug exposure was revealed.•Each drug altered the expression of the pregnane X receptor.</description><subject>Animals</subject><subject>Antioxidant enzyme activity</subject><subject>Antioxidants</subject><subject>Antioxidants - analysis</subject><subject>Aquatic environment</subject><subject>Aquatic habitats</subject><subject>Aquatic toxicology</subject><subject>Biodiversity</subject><subject>CYP1A protein</subject><subject>Cytochrome P450</subject><subject>Degeneration</subject><subject>Dexamethasone</subject><subject>Dexamethasone - toxicity</subject><subject>Drug dependence</subject><subject>Exposure</subject><subject>Fish</subject><subject>Flatfishes</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>Glycogen</subject><subject>Glycogens</subject><subject>Hemorrhage</subject><subject>Hemorrhage - chemically induced</subject><subject>Imidazole</subject><subject>Imidazoles - toxicity</subject><subject>Liver - drug effects</subject><subject>Marine ecosystems</subject><subject>Peroxidase</subject><subject>Pharmaceuticals</subject><subject>Risk Assessment</subject><subject>Superoxide dismutase</subject><subject>Transcriptome</subject><subject>Vertebrates</subject><subject>Warfarin</subject><subject>Warfarin - toxicity</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>1382-6689</issn><issn>1872-7077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuO1DAQRSMEYh7wAyyQJTYsJo0fieOg2aARMEgjsQDWlrtS6XaTxMHljOh_4iNx1AMLFmz8uDp1dVW3KF4IvhFc6DeHDSY3bySXMgvKSPmoOBemkWXDm-Zxfmet1Nq0Z8UF0YFzUStlnhZnqs4GdVudF7--7ENMZcI4Mvw5B1oishTYvHdxdIBL8uAGYhPuXPL3OByZH2cHidjoop-Q9YNLvac9oxnBI71lt55SGMJunbxiWx9gj-P6YW7q2BgGhGVwkcGwILE-xKwzPyXcRZewYwiBjpRwZNHTd-aIkGjEKT0rnvQ5DD5_uC-Lbx_ef725Le8-f_x08-6uhEqaVHYCukpxIQXXEjTUhuej1rJVW2x1LZRoXKfMtt6CEYAgu9qB0KaHVouqV5fF65PvHMOPnDHZ0RPgMLgJw0JWalnpujWqyuirf9BDWOKU02VKmaZRUohMyRMFMRBF7O0cfd7f0Qpu1y7twa5d2rVLe-oyD718sF62I3Z_R_6Ul4HrE4B5F_ceo6VcwATY-YiQbBf8__x_A6q7s7s</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Pes, Katia</creator><creator>Ortiz-Delgado, Juan B.</creator><creator>Sarasquete, Carmen</creator><creator>Laizé, Vincent</creator><creator>Fernández, Ignacio</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>202202</creationdate><title>Short-term exposure to pharmaceuticals negatively impacts marine flatfish species: Histological, biochemical and molecular clues for an integrated ecosystem risk assessment</title><author>Pes, Katia ; Ortiz-Delgado, Juan B. ; Sarasquete, Carmen ; Laizé, Vincent ; Fernández, Ignacio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-d1cd430121062c6c5806c556293be9651317ad38b5bc81cec2d5ac168fc9614f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Antioxidant enzyme activity</topic><topic>Antioxidants</topic><topic>Antioxidants - analysis</topic><topic>Aquatic environment</topic><topic>Aquatic habitats</topic><topic>Aquatic toxicology</topic><topic>Biodiversity</topic><topic>CYP1A protein</topic><topic>Cytochrome P450</topic><topic>Degeneration</topic><topic>Dexamethasone</topic><topic>Dexamethasone - toxicity</topic><topic>Drug dependence</topic><topic>Exposure</topic><topic>Fish</topic><topic>Flatfishes</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Glutathione</topic><topic>Glutathione peroxidase</topic><topic>Glycogen</topic><topic>Glycogens</topic><topic>Hemorrhage</topic><topic>Hemorrhage - chemically induced</topic><topic>Imidazole</topic><topic>Imidazoles - toxicity</topic><topic>Liver - drug effects</topic><topic>Marine ecosystems</topic><topic>Peroxidase</topic><topic>Pharmaceuticals</topic><topic>Risk Assessment</topic><topic>Superoxide dismutase</topic><topic>Transcriptome</topic><topic>Vertebrates</topic><topic>Warfarin</topic><topic>Warfarin - toxicity</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pes, Katia</creatorcontrib><creatorcontrib>Ortiz-Delgado, Juan B.</creatorcontrib><creatorcontrib>Sarasquete, Carmen</creatorcontrib><creatorcontrib>Laizé, Vincent</creatorcontrib><creatorcontrib>Fernández, Ignacio</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pes, Katia</au><au>Ortiz-Delgado, Juan B.</au><au>Sarasquete, Carmen</au><au>Laizé, Vincent</au><au>Fernández, Ignacio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-term exposure to pharmaceuticals negatively impacts marine flatfish species: Histological, biochemical and molecular clues for an integrated ecosystem risk assessment</atitle><jtitle>Environmental toxicology and pharmacology</jtitle><addtitle>Environ Toxicol Pharmacol</addtitle><date>2022-02</date><risdate>2022</risdate><volume>90</volume><spage>103822</spage><epage>103822</epage><pages>103822-103822</pages><artnum>103822</artnum><issn>1382-6689</issn><eissn>1872-7077</eissn><abstract>The marine habitat and its biodiversity can be impacted by released pharmaceuticals. The short-term (7 days) effect of 3 commonly used drugs – warfarin, dexamethasone and imidazole – on Senegalese sole (Solea senegalensis) juveniles was investigated. Occurrence of hemorrhages, histopathological alterations, antioxidant status, activity of antioxidant enzymes and expression of genes involved in the xenobiotic response (pxr, abcb1 and cyp1a), were evaluated. The results showed a time and drug-dependent effect. Warfarin exposure induced hemorrhages, hepatocyte vacuolar degeneration, and altered the activity of glutathione peroxidase (GPx) and the expression of all the studied genes. Dexamethasone exposure increased liver glycogen content, altered antioxidant status, GPx and superoxide dismutase activities, as well as abcb1 and cyp1a expression. Imidazole induced hepatocyte vacuolar degeneration and ballooning, and altered the antioxidant status and expression of the tested genes. The present work anticipates a deeper impact of pharmaceuticals on the aquatic environment than previously reported, thus underlining the urgent need for an integrated risk assessment.
•Warfarin, dexamethasone and imidazole are PPCPs which release has environmental concerns.•Short-term exposure of warfarin, dexamethasone and imidazole induced liver damage.•A specific antioxidant response to drug exposure was revealed.•Each drug altered the expression of the pregnane X receptor.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>35101594</pmid><doi>10.1016/j.etap.2022.103822</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental toxicology and pharmacology, 2022-02, Vol.90, p.103822-103822, Article 103822 |
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| subjects | Animals Antioxidant enzyme activity Antioxidants Antioxidants - analysis Aquatic environment Aquatic habitats Aquatic toxicology Biodiversity CYP1A protein Cytochrome P450 Degeneration Dexamethasone Dexamethasone - toxicity Drug dependence Exposure Fish Flatfishes Gene expression Genes Glutathione Glutathione peroxidase Glycogen Glycogens Hemorrhage Hemorrhage - chemically induced Imidazole Imidazoles - toxicity Liver - drug effects Marine ecosystems Peroxidase Pharmaceuticals Risk Assessment Superoxide dismutase Transcriptome Vertebrates Warfarin Warfarin - toxicity Water Pollutants, Chemical - toxicity |
| title | Short-term exposure to pharmaceuticals negatively impacts marine flatfish species: Histological, biochemical and molecular clues for an integrated ecosystem risk assessment |
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