Exploration and structure-based engineering of alkenal double bond reductases catalyzing the CαCβ double bond reduction of coniferaldehyde

Lignin, a complex aromatic polymer, represents a significant obstacle in lignocellulosic biomass utilization. The polymerization of lignin occurs by radical couplings, which mainly form ether and C–C bonds between monolignol units. The chemical stability of these bonds between monolignol units cause...

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Veröffentlicht in:	New biotechnology 2022-05, Vol.68, p.57-67
Hauptverfasser:	Kamimura, Naofumi, Watanabe, Shingo, Sugimoto, Keisuke, Senda, Miki, Araki, Takuma, Yu, Hong Yang, Hishiyama, Shojiro, Kajita, Shinya, Senda, Toshiya, Masai, Eiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein - analogs & derivatives Alkenal double bond reductase Coniferaldehyde Crystal structure Enzyme engineering Lignin - chemistry Lignin manipulation Oxidoreductases - genetics Oxidoreductases - metabolism Substrate Specificity
Online-Zugang:	Volltext
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